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WHAT TYPE OF CHEMO?

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denise07 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote denise07 Quote  Post ReplyReply Direct Link To This Post Posted: Oct 27 2010 at 8:29pm

Istorey, Your treatment seems a little different,You had 6 rounds of treatment over a four day period? Usually the treatment is weeks apart.Noticed you were diagnosed in 04 great job.

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msjag View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 2:40pm
hi I am new here, and so grateful for this site.  I will be having chemo in a couple of weeks. I had a lumpectomy one week ago for 1 cm grade 3 , 0/2 negative nodes.  I am 51, no family history.  Did all of you have chemo through IV?  some pills?  and when you say rounds do you mean, one week you had it, one you didn't?   Also, since you all seem to basically have the same chemo drugs, did you feel "ok" after a few days, or on your weeks "off?"   I will have appt with oncologist, to ask/verify treatment, I just want to be clear on what this all means.
 
Thanks so much for your input. so helpful to me as I am just starting this journey!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote unklez Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 2:49pm
Dear msjag,

We are sorry that you have the misfortune to be here. But also want to reassure you that this website is a great information and support resource for patients and caregivers.

Yes chemo is thru' IV. There are some drugs in trials, e.g. the bisphosphonates - technically not chemo - that are also available in pill form. A very commonly used chemo regimen is dose dense, which is given once every 2 weeks. The worst side effects are from 2-5 days after the chemo infusion.

Good luck on your journey.

Wife Dx: Jul/09. Age: 37. Size: 3cm. BRCA: -ve. Lumpectomy: Aug/09. Micromet 1/9 node. Chemo Start: Sep/09. E5103. DD ACB-> DD Abraxane (Taxol reaction). Zometa (S0307). Canadian Fraction Rads.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 3:37pm
Thanks!!  Just curious about some people having chemo every three weeks, vs every two...must be up to the onc.   Any helpful hints on managing side effects would be greatly appreciated!! Don't know if I'm on the right forum to ask that, I'll find my way around!  Thanks again.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote trip2 Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 5:01pm
Welcome,
 
Some of us have treatments 2 or 3 weeks apart.  We have a forum section called "TNBC News/Resources and in there you will find a topic called "chemo tips", read thru those tips, they will be a great help and also you can always post any questions to us and we'll try to help.
 
 
The website http://www.lbbc.org is another good one.  They have a new booklet describing TNBC which you can download.
 
 
Also near the top is a link called Resources which might be of help.
Stage 2 2003
Stage 1 2007
BRCA 1+
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msjag View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 5:12pm
Thank you, Pam!!  I will check those out.
 
JoAnn
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denise07 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote denise07 Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 8:32pm
msjac, I am sure you will do fine with your chemo you have to let us know when you start. Thank god I had no problems with my chemo. Good luck!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Oct 30 2010 at 8:42pm
I will, thanks for the encouragement.  Just hoping I will be able to work a few days each week, as I carry the health insurance!!  All the tips I am reading about will be so helpful.  What a great site this is!! So grateful to have found it.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote unklez Quote  Post ReplyReply Direct Link To This Post Posted: Oct 31 2010 at 6:27pm
Dear msjag,

Traditionally most chemo was given every 3 weeks between infusions. This gave the patients time to recover from side effects and for the white blood cell count to come back into normal range. With the discovery of drugs to reduce/prevent vomiting/nausea (e.g. emend) and - probably more importantly - to boost the white blood cell count (e.g. neulasta/neupogen), the dose dense regimen (every 2 weeks) became a possibility.

Some clinical trials have indicated that some of the chemos are more effective in the dose dense cycle than in the 3 week cycle.

Hopefully this provides some background which I'd suggest be used in a consultation with the oncologist to determine the best chemo regimen for a particular patient.

Hopefully you will find the tips in the links provided by Pam useful. Also wanted to add that some people take chemo on Wednesdays or Thursdays to maximize their working days during chemo.

Wife Dx: Jul/09. Age: 37. Size: 3cm. BRCA: -ve. Lumpectomy: Aug/09. Micromet 1/9 node. Chemo Start: Sep/09. E5103. DD ACB-> DD Abraxane (Taxol reaction). Zometa (S0307). Canadian Fraction Rads.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Oct 31 2010 at 7:59pm
Thank you.  I realize from reading posts that everyone can be so different, so I guess I will know soon enough what I will experience!    Tomorrow I get the pathology report from lumpectomy, and although I realize there is only something like a  1% chance the tumor  receptors will be positive instead of triple negative like the biopsy, I can still have a little hope!!!  And if not,  look what I've gained, wonderful people willing to help with this journey!!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote denise07 Quote  Post ReplyReply Direct Link To This Post Posted: Nov 01 2010 at 7:32pm
msjag,Any news!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Nov 01 2010 at 8:35pm

Denise, I am still in shock, as I think my surgeion, husband is too....er- pr+ and her2-.   retesting everything and now having onc  (not sure if that's the initials) test done also.   He said its been a long time since this has happened.  Even if it comes back triple N...again.... the rest of the report was good,1.2 cm,  node negative, clear margins, no lympatic or vascular....so that's good!!! (biopsy was tested twice, two different places, triple N, but whole tumor may say different) won't find out for at least 2 weeks.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote dmwolf Quote  Post ReplyReply Direct Link To This Post Posted: Nov 01 2010 at 10:08pm
That's great, msjag!   You should still do chemo, but your risk might be somewhat reduced.  Though as for chemo, maybe, just maybe, you should do a mammaprint test to see whether your tumor is low risk.  Who knows, maybe it is.  If so, you can avoid chemo altogether.  (wouldn't that be nice!)
Best,
Denise W
DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote clwille708 Quote  Post ReplyReply Direct Link To This Post Posted: Nov 04 2010 at 7:15am
Yea Guygirl!  Almost there.  I am on the same "plan" as you, and had #1 yesterday, with 7 to go.  I feel pretty good so far.   Linda
Dx Aug/10,age 62, Lump & SNB Sept/10,1.7 cm, grade 3, Triple Neg, Nodes clear. Annual screening due to family history of Ovarian C. BRCA - Chemo DD AC -->Taxol 21 Rads done. Hugs -Linda
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Nov 04 2010 at 3:52pm
I'm not sure what a mammoprint is...I'm having an oncotype dx test...  PR came back positive;  it said 25-75 percent.   Anyone ever hear of iPR positive and ER is -.? (her2-  also)  I'm not really thinking anything is going to change, maybe  not as agressive or as I learned here "dense" treatment, but then again, who knows.  I feel lucky about the test results, so I guess...one step at a time...wish I was in treatment already though....the quicker I start the sooner I end!!!
 
 
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Post Options Post Options   Thanks (0) Thanks(0)   Quote fighter_34 Quote  Post ReplyReply Direct Link To This Post Posted: Nov 05 2010 at 1:42pm
I am being treated w/ Taxotere and Cytoxin. I feel pretty good w/ the choice so far.
 
 
IDC, Stage 1, Grade 3, no node involved, DMX 9/23/2010 Chemo Taxotere and Cytoxin 6 rounds
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Nov 23 2010 at 10:12pm
well, how some things change!! I guess there was a problem with the serum something like that, that tested progesterone receptor, and it turns out I am still triple negative, not pr+...and we even had a + party at work!! oh well!!
 
Anyway, I will be staring T/C chemo on Dec 2,  bonescan/chest xray tomorrow, with a scan of my abdomen to be done if insurance covers it.  Onc said most insurances don't cover pet scan as a screening, only if symptoms.   Chemo will be 1 every 3 weeks. no node involvement, 1 cim, stage 1  Onc said they can't prove anding  the red devil does anybetter than T/C  for non node involvement.  Was wondering what your thoughts were on that?
 
 
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Hi
My mom is in a similar situation.  She had a 1cm tumor, with no lymph node involvement.  Stage 1, Grade 3.  I took her to two oncologists and both said the same thing: TC one every three x 4 treatments.  Then after that, she will get radiation for several weeks.  The oncologists both said the same thing as your oncologist - no benefit extra benefit with the Red Devil.  She has completed 1 treatment and will have her next on Dec 2.  Her White Blood Cell dropped after treatment and she required Neupogen.  Also, she developed a bad thrush, but that resolved by using several mouth rinses.  Good luck with everything.
My mom- 62y/o @ DX 9/2010; lumpectomy, Stage 1B, Grade 3, 1cm tumor left breast, neg nodes; TC once every 3 weeks x 4 doses then 33 rads; BRCA negative; 9/2011 mammo NED; 3/2012 MRI NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote msjag Quote  Post ReplyReply Direct Link To This Post Posted: Nov 24 2010 at 3:05pm
I start my chemo the same day your mom has her second round.   Hope she does well.   Did the mouth rinses get rid of the thrush? do you recommend the mouth washes/rinsing before they even start?  Thanks for all the help everyone!!!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote chyxgrl Quote  Post ReplyReply Direct Link To This Post Posted: Nov 24 2010 at 3:40pm
They recommended using alcholol free mouth wash after you brush (like biotene) before chemo.  You want to switch to an alcholol free mouth wash during all of chemo because chemo can dry the mouth out.  Also, my mom uses a spray artificial saliva throughout the day because it is soothing. Three days after her chemo is when she got a few mouth sores and thrush.  She was ordered Magic Mouthwash (combo of liquid benadryl/lidocaine/mylanta) for the sores and Nystatin (for the fungus of thrush).  She also rinsed with salt/water/baking soda (recommended by Donna from this site). Because her white blood cells dropped so low, the thrush spread quickly and took all week to resolve.  All the rinses definitely did help her though.  They were soothing and did help clear it faster. You may want to ask for an order of Nystatin Suspension the day you get the chemo, that way if you get the thrush over the weekend, you can fill the order at a pharmacy.  Also ask the doctor about when you should come back for blood work.  I am guessing they will ask to see you Monday just to check on your white blood cell level.  My mom needed a shot of Neupogen on the Monday, Wednesday, Thursday and Friday following the chemo.  The next time she goes (12/2), she was told already that will get a shot of Neulasta on 12/3 because that is a longer acting agent and she will not have to return for as many shots as she did last time.  Unfortunately, there was no way to predict that her white blood cell count would drop so low (they knew it would drop, but hers got real low).  She will also be asking if she should use the Nystatin starting on 12/2.
 
Another note - because you are getting the chemo on a Thursday, make sure you have the number of the doctor on call for the weekend.  My mom felt fine on Friday and even Saturday.  Sunday is when she felt bad and noticed a few mouth sores/thrush.  She called the number and a doctor called her back in under two minutes and called the pharmacy ASAP.  My mom also started taking her temperature twice a day after chemo because they warned of fever.  You may not feel it, but you should tell the doctor about any fever, even a low one.  The Tuesday - Thursday after chemo she had a fever and in addition to getting those Neupogen shots, she got an antibiotic just in case she had an infection.  She was right under 101F.  If she hit 101F, she would have needed the hospital for IV antibiotics.
 
I know this probably sounds worse than what it was.  I just want you to catch everything early.  My mom was a little tired throughout the week, but despite the mouth sores and thrush, she had an appetite and maintained most of her normal activities (she stayed in when feverish, except for md appts, as a precaution but she felt well enough to leave the house).  She never felt nauseous (got dexamethasone and Emend for treatment, got Aloxi during treatment, and Emend after treatment).  She never threw up, never missed a meal, never slept in, rarely went to sleep early, etc.  Getting thrush and having the white blood cell count drop are managable side effects.  I was probably more upset than she was over this because I felt bad for her.  But she was just like, "Ok..no prob..they have something to treat that...I'll just go to the doctor".  So keep a positive attitude.  Tomorrow she is cooking Thanksgiving dinner even though we all offered to help.  She says she feels completely fine and wants to cook.  
 
Please let me know if you have any other questions.  I'll be rooting for you next Thur.
My mom- 62y/o @ DX 9/2010; lumpectomy, Stage 1B, Grade 3, 1cm tumor left breast, neg nodes; TC once every 3 weeks x 4 doses then 33 rads; BRCA negative; 9/2011 mammo NED; 3/2012 MRI NED
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