Small pr+ and tamoxifin |
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sassygirl012 
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Joined: Dec 07 2013 Location: michigan Status: Offline Points: 7 |
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 Topic: Small pr+ and tamoxifinPosted: Dec 14 2013 at 11:29am |
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I have 10% pr+ but er and her2-. Wondering if tamoxifin would be a possible benefit for me?
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Dx May 2013. Invasive ductal card. Grade 3. Stage 2A. 1 node positive 3.5mm. Lumpectomy with clear margins.
ER- PR+(5-10% 2+ intensity), HER-2 NEG. BRCA NEG. Treatment: TCx6 and 33 rads. |
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dmwolf
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Joined: Jan 22 2009 Location: Berkeley, CA Status: Offline Points: 3619 |
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Posted: Dec 17 2013 at 4:32pm |
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YES, you should take it. 10% is not that low.
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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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123Donna
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Joined: Aug 24 2009 Location: St. Louis, MO Status: Offline Points: 13510 |
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Posted: Dec 17 2013 at 7:29pm |
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Denise,
Is Tamoxifin used for progesterone positive too? I thought it was only estrogen positive that Tamoxifin benefits. I learn something every day! Thanks Donna
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
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Charlene
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Joined: Aug 14 2010 Location: Atlanta, GA Status: Offline Points: 613 |
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Posted: Dec 18 2013 at 4:55pm |
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Actually I was under the same impression--that estrogen was the determining factor, not progesterone. An ER negative, PR positive cancer is one of the more rare types, isn't it?
Just asking . . . Charlene
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DX 3/10 @59 ILC/TNBC
Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads 3/14:NED |
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dmwolf
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Joined: Jan 22 2009 Location: Berkeley, CA Status: Offline Points: 3619 |
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Posted: Dec 18 2013 at 7:07pm |
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Yes, tamoxifen is used for hormone receptor positive breast cancer. That is any breast cancer with ER and/or PG expression of at least a few percent. In your shoes I would definitely take it.
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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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123Donna
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Joined: Aug 24 2009 Location: St. Louis, MO Status: Offline Points: 13510 |
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Posted: Dec 18 2013 at 8:01pm |
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Denise,
You teach us something new everyday! Thank you friend! While this is from 2005, I found this reference: Finally, in view of recent trials showing a significant advantage for the sequence of tamoxifen followed by an aromatase inhibitor, it is an intriguing possibility that PR status could be used to select initial therapy. ER- and PR-positive tumors might be best treated by tamoxifen followed by an aromatase inhibitor, while ER+/PR− tumors might receive initial treatment with an aromatase inhibitor because of their relative resistance to tamoxifen. This hypothesis should be tested in ongoing clinical trials. Donna
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
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