Small pr+ and tamoxifin
Printed From: TNBC Foundation
Category: TNBC Forums
Forum Name: Welcome New Members
Forum Description: A place to introduce yourself to our community
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=11690
Printed Date: Mar 26 2026 at 5:09pm
Software Version: Web Wiz Forums 12.01 - http://www.webwizforums.com
Topic: Small pr+ and tamoxifin
Posted By: sassygirl012
Subject: Small pr+ and tamoxifin
Date Posted: Dec 14 2013 at 11:29am
I have 10% pr+ but er and her2-. Wondering if tamoxifin would be a possible benefit for me?
-------------
Dx May 2013. Invasive ductal card. Grade 3. Stage 2A. 1 node positive 3.5mm. Lumpectomy with clear margins.
ER- PR+(5-10% 2+ intensity), HER-2 NEG. BRCA NEG.
Treatment: TCx6 and 33 rads.
|
Replies:
Posted By: dmwolf
Date Posted: Dec 17 2013 at 4:32pm
YES, you should take it. 10% is not that low.
-------------
DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
|
Posted By: 123Donna
Date Posted: Dec 17 2013 at 7:29pm
|
Denise,
Is Tamoxifin used for progesterone positive too? I thought it was only estrogen positive that Tamoxifin benefits. I learn something every day! Thanks
Donna
-------------
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
|
Posted By: Charlene
Date Posted: Dec 18 2013 at 4:55pm
|
Actually I was under the same impression--that estrogen was the determining factor, not progesterone. An ER negative, PR positive cancer is one of the more rare types, isn't it? Just asking . . . Charlene
-------------
DX 3/10 @59 ILC/TNBC
Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision
SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads
3/14:NED
|
Posted By: dmwolf
Date Posted: Dec 18 2013 at 7:07pm
Yes, tamoxifen is used for hormone receptor positive breast cancer. That is any breast cancer with ER and/or PG expression of at least a few percent. In your shoes I would definitely take it.
-------------
DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
|
Posted By: 123Donna
Date Posted: Dec 18 2013 at 8:01pm
|
Denise,
You teach us something new everyday! Thank you friend!
While this is from 2005, I found this reference:
Finally, in view of recent trials showing a significant advantage for the sequence of tamoxifen followed by an aromatase inhibitor, it is an intriguing possibility that PR status could be used to select initial therapy. ER- and PR-positive tumors might be best treated by tamoxifen followed by an aromatase inhibitor, while ER+/PR− tumors might receive initial treatment with an aromatase inhibitor because of their relative resistance to tamoxifen. This hypothesis should be tested in ongoing clinical trials.
http://jco.ascopubs.org/content/23/4/931" rel="nofollow - http://jco.ascopubs.org/content/23/4/931
Donna
-------------
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
|
|