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EWKSeattle View Drop Down
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    Posted: Mar 05 2009 at 4:57pm
Tried to post this to "News, Resources and Tips" but I'm not allowed to post there.
 
Dx 05/06 Stage IIIC
Local Recurrence 01/07
Mets in opposite side axilla nodes 12/07
Mets to mediastinal nodes confirmed 11/08
NED March 2009-March 2010
Brain met March 2010.
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Points: 5004 		Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Mar 05 2009 at 6:41pm
Thanks for the article. I'll be asking my onc if he's seen it since I've had the Sunitinib included in my chemo and it sounds as though it may have enhanced the ability of recurrence for me. Yipee.
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Points: 3814 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Nancy Quote  Post ReplyReply Direct Link To This Post Posted: Mar 06 2009 at 7:20am
Elizabeth,
 
I posted it in the resource section. Thank you very much.
Nancy


Edited by Nancy - Mar 08 2009 at 11:52am
Nancy
DD Lori dx TNBC June 13,2007
Lumpectomy due to incorrect dx of a cyst
mastectomy July 6 2007
chemo ACT all 3 every 3 weeks 6 tx Aug-Nov
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Thought I'd bump this.  Very worrying results.

Anyone put it to their Onc? Confused
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Hi Frenchie,
 
Indeed disturbing.  Sometimes they seem to take us in circles with these new hopeful meds..  Fingers crossed it is still better than not and that they will fix what is wrong and quickly.
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mainsailset View Drop Down
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Points: 5004 		Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2009 at 10:48am
Fresh out of appt with onc and we read the Science Daily article together. His response was that he has been using the Sutent (which is an inhibitor and which I used) for years in treatment of kidney cancer. He pointed out that in the flip side, research that looks promising with mice can prove to be a puddle of muck once it is tried on humans.
 
He indicatged that what he's seen in humans he has treated with the Sutent has been successful in reducing and controlling tumors and has not tranlated into an abnormal number of mets after or during treatment. All in all he's still a believer in its effectiveness.
 
Lastly,  this article was not specific to TN but I asked him what he thought of the inhibitors with TN as he has quite a number of TN in hs care now. He was very positive and pointed to the fact that my tumor was large when we found it and basically doubled in size in 6 weeks before treatment and that the Sutent/inhibitor not only stopped the growth in its tracks but has reduced the tumor (at time of 1st chemo was nearly 14 cm)
to where last MRI doesn't even give a size...
 
Made me feel better.
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trip2 View Drop Down
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Points: 8549 		Post Options Post Options   Thanks (0) Thanks(0)   Quote trip2 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2009 at 5:37pm
That should make you feel better Mainy, thank you so much for sharing what you were told today.  It really helps all of us.
 
It is so good to see you have an Oncologist that actually will discuss something like this article with you.
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Points: 156 		Post Options Post Options   Thanks (0) Thanks(0)   Quote JanetK Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2009 at 6:21pm
Oh, Gee! Now I am so confused! This study showed a higher rate of metasisis after taking Avastin?
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Points: 5004 		Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2009 at 11:27pm
We read it as the group of inhibitors, Sutent was specifically mentioned at top of page 2 and since that what I was involved with we talked about that but my onc's response carries through for the inhibitors in general from his personal experience.
 
He did not discount the research with mice but was pointing out that the research had not yet been translated completely into how it affects human experience/reaction with the inhibitors. It's not yet a red flag but indeed a yellow one.
 
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trip2 View Drop Down
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Points: 8549 		Post Options Post Options   Thanks (0) Thanks(0)   Quote trip2 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 11 2009 at 3:01pm
Janet it is confusing.
 
I was reading something the other day which escapes my mind but there was discussion about how sometimes things work just great in mice but when it comes to humans it may be a different story.
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mainsailset View Drop Down
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Points: 5004 		Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Mar 11 2009 at 3:09pm
I hadn't seen the name Avastin listed in the article itself but have assumed that it is in the inhibitor class...and yes Pam that was what my onc was saying was that too often a mouse success or even a disaster does not necessarily mean it will have the exact same result in humans.
 
Again, maybe not a red flag, but a yellow one for sure.
 
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sberger View Drop Down
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Points: 26 		Post Options Post Options   Thanks (0) Thanks(0)   Quote sberger Quote  Post ReplyReply Direct Link To This Post Posted: Mar 16 2009 at 7:17am
There was an article in the London Financial Times last summer that said Avastin could not work in the adjuvant setting because there were no tumors to cut off supply.  That article was largely dismissed as false and that theory went away.  This one could too.   The first adjuvant Avastin trial in colon cancer will be out in April 09.  This is not breast cancer but certainly will be watched.  Genetech says that if it works in the metestactic  setting it will work in the adjuvant setting.  It is still not proven but certainly I would remain optimistic.
 
Susan
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sberger View Drop Down
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Points: 26 		Post Options Post Options   Thanks (0) Thanks(0)   Quote sberger Quote  Post ReplyReply Direct Link To This Post Posted: Mar 16 2009 at 7:43am

One more point that is interesting about the Avastin story lately.  Genetech, that makes Avastin, was just taken over by Roche.  The take over ended up friendly but was hostile in the begining.  Roche knew they had to buy Genetect before the trial results in April (for colon cancer), because if positive, they could no longer afford to buy Genetech.  This is just greedy wall street stuff, but since I had 8 infusions in the adjuvant setting I'm still very encouraged by what I am reading!
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trip2 View Drop Down
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Points: 8549 		Post Options Post Options   Thanks (0) Thanks(0)   Quote trip2 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 16 2009 at 8:39am

Thank you sberger for the information.  We appreciate it and it's good to hear that we might yet have a good one in Avastin.
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Stage 1 2007
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