Avastin Data
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URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=3041
Printed Date: Mar 26 2026 at 5:53pm
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Topic: Avastin Data
Posted By: EWKSeattle
Subject: Avastin Data
Date Posted: Mar 05 2009 at 4:57pm
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Tried to post this to "News, Resources and Tips" but I'm not allowed to post there.
http://www.sciencedaily.com/releases/2009/03/090302133306.htm - http://www.sciencedaily.com/releases/2009/03/090302133306.htm ------------- Dx 05/06 Stage IIIC Local Recurrence 01/07 Mets in opposite side axilla nodes 12/07 Mets to mediastinal nodes confirmed 11/08 NED March 2009-March 2010 Brain met March 2010. |
Replies:
Posted By: mainsailset
Date Posted: Mar 05 2009 at 6:41pm
| Thanks for the article. I'll be asking my onc if he's seen it since I've had the Sunitinib included in my chemo and it sounds as though it may have enhanced the ability of recurrence for me. Yipee. |
Posted By: Nancy
Date Posted: Mar 06 2009 at 7:20am
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Elizabeth,
I posted it in the resource section. Thank you very much.
Nancy ------------- Nancy DD Lori dx TNBC June 13,2007 Lumpectomy due to incorrect dx of a cyst mastectomy July 6 2007 chemo ACT all 3 every 3 weeks 6 tx Aug-Nov 28 rads ended Jan 2008 |
Posted By: Frenchie
Date Posted: Mar 07 2009 at 10:02pm
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Thought I'd bump this. Very worrying results. Anyone put it to their Onc?  |
Posted By: trip2
Date Posted: Mar 08 2009 at 11:38am
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Hi Frenchie,
Indeed disturbing. Sometimes they seem to take us in circles with these new hopeful meds.. Fingers crossed it is still better than not and that they will fix what is wrong and quickly. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: mainsailset
Date Posted: Mar 10 2009 at 10:48am
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Fresh out of appt with onc and we read the Science Daily article together. His response was that he has been using the Sutent (which is an inhibitor and which I used) for years in treatment of kidney cancer. He pointed out that in the flip side, research that looks promising with mice can prove to be a puddle of muck once it is tried on humans.
He indicatged that what he's seen in humans he has treated with the Sutent has been successful in reducing and controlling tumors and has not tranlated into an abnormal number of mets after or during treatment. All in all he's still a believer in its effectiveness.
Lastly, this article was not specific to TN but I asked him what he thought of the inhibitors with TN as he has quite a number of TN in hs care now. He was very positive and pointed to the fact that my tumor was large when we found it and basically doubled in size in 6 weeks before treatment and that the Sutent/inhibitor not only stopped the growth in its tracks but has reduced the tumor (at time of 1st chemo was nearly 14 cm)
to where last MRI doesn't even give a size...
Made me feel better.
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Posted By: trip2
Date Posted: Mar 10 2009 at 5:37pm
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That should make you feel better Mainy, thank you so much for sharing what you were told today. It really helps all of us.
It is so good to see you have an Oncologist that actually will discuss something like this article with you. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: JanetK
Date Posted: Mar 10 2009 at 6:21pm
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Oh, Gee! Now I am so confused! This study showed a higher rate of metasisis after taking Avastin?
------------- TNBC feb 13,2009 2.6x 3.5 neoadjuvant chemo 8 rounds Lumpectomy successful Oct 09 axillary node dissection Nov 09 still awaiting results |
Posted By: mainsailset
Date Posted: Mar 10 2009 at 11:27pm
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We read it as the group of inhibitors, Sutent was specifically mentioned at top of page 2 and since that what I was involved with we talked about that but my onc's response carries through for the inhibitors in general from his personal experience.
He did not discount the research with mice but was pointing out that the research had not yet been translated completely into how it affects human experience/reaction with the inhibitors. It's not yet a red flag but indeed a yellow one.
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Posted By: trip2
Date Posted: Mar 11 2009 at 3:01pm
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Janet it is confusing.
I was reading something the other day which escapes my mind but there was discussion about how sometimes things work just great in mice but when it comes to humans it may be a different story. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: mainsailset
Date Posted: Mar 11 2009 at 3:09pm
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I hadn't seen the name Avastin listed in the article itself but have assumed that it is in the inhibitor class...and yes Pam that was what my onc was saying was that too often a mouse success or even a disaster does not necessarily mean it will have the exact same result in humans.
Again, maybe not a red flag, but a yellow one for sure.
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Posted By: sberger
Date Posted: Mar 16 2009 at 7:17am
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There was an article in the London Financial Times last summer that said Avastin could not work in the adjuvant setting because there were no tumors to cut off supply. That article was largely dismissed as false and that theory went away. This one could too. The first adjuvant Avastin trial in colon cancer will be out in April 09. This is not breast cancer but certainly will be watched. Genetech says that if it works in the metestactic setting it will work in the adjuvant setting. It is still not proven but certainly I would remain optimistic.
Susan
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Posted By: sberger
Date Posted: Mar 16 2009 at 7:43am
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One more point that is interesting about the Avastin story lately. Genetech, that makes Avastin, was just taken over by Roche. The take over ended up friendly but was hostile in the begining. Roche knew they had to buy Genetect before the trial results in April (for colon cancer), because if positive, they could no longer afford to buy Genetech. This is just greedy wall street stuff, but since I had 8 infusions in the adjuvant setting I'm still very encouraged by what I am reading! |
Posted By: trip2
Date Posted: Mar 16 2009 at 8:39am
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Thank you sberger for the information. We appreciate it and it's good to hear that we might yet have a good one in Avastin. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |