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Xeloda Disappoints in Early Triple-Negative Breast

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rstar View Drop Down
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    Posted: Dec 11 2018 at 12:05pm
However, they do state that in women with non-basal like phenotype, capecitabine did offer some advantage, with a 5-year DFS rate of 82.6% versus 72.9% among women with other phenotypes.
Seems like basal vs non basal phenotype plays the main role here.


https://www.medpagetoday.com/meetingcoverage/sabcs/76734

Edited by rstar - Dec 11 2018 at 7:44pm
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JenAus01 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote JenAus01 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 12 2018 at 2:40am
In reading through both trials from the US and Japan, there is a major difference in the  dose of Xeloda given to participants.    The US trial (as per the above article) is 1000 mg per day and the Japanese trail (Create-X) is 2500 mg per day.   Could this be the reason for the difference in results?  

As discussed in the US article shared above, agree that more research is needed to individualize treatment given there are many sub types of TNBC, but don't discount this treatment option if it applies to you until you talk to your oncologist.   


   


Edited by JenAus01 - Dec 12 2018 at 2:47am
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 12 2018 at 7:48am
JenAus01,

Good observation!  
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote JenAus01 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 13 2018 at 1:52am
A very observant friend with a chemistry background noticed the differences in doses.  but thank you Donna.  
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