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Post Options Post Options   Thanks (0) Thanks(0)   Quote ds21 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 13 2012 at 7:39pm
Another recent article from The Scientist

http://the-scientist.com/2012/03/01/vitamin-d-on-trial/

and background from the Institute of Medicine

http://www.nap.edu/catalog.php?record_id=13050

and the Vitamin D council (which Donna has posted previously)

http://www.vitamindcouncil.org/

David

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Post Options Post Options   Thanks (0) Thanks(0)   Quote TNinTN Quote  Post ReplyReply Direct Link To This Post Posted: Mar 20 2012 at 12:17pm
Update: Susan's Vit D3 level in June 2011 was 41. At the time she had been taking around 5,000 I.U.'s per day combined (Vit D3 supplement plus amounts contained in other supplements). Beginning in July, 2011, she increased her total to a combined amount of around 8,000/day. We had her level tested again last week and it is now 46. We are planning to increase her total Vit D supplement amount to around 10,000/day (8,000 Vit D3 plus another 2,000 from multivitamin, calcium, etc.) She takes her Vitamin D with her calcium supplement with a meal. With the warmer weather, we hope to spend more time outside, but Susan has olive toned skin which I understand somewhat inhibits her vitamin D absorption from the sun. Her onc plans to retest her in June. Hopefully, she will be able to get it above 50 by then.
Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Autumn10182001 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 20 2012 at 7:57pm
i take 9600 units a day...  6 days a week...  and can only get my vit d3 up to 44.....   I started at either 12 or 19, can't remember, I would like to get to 60.... 
DX2/99 Stg I,ER+PR+ Chemo lumpectomy - Neg nodes,rads, tamox,femara. DX4/09, Stg IIB /III, TNBC IDC, Grade III, 2.5CM, mastectomy. 4AC DD,12 wkly taxol,BRAC1&2Neg, Right Mast 11/25/09
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Mar 28 2012 at 5:09pm

Vitamin D3 for High-Risk Women

High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer (SWOG-S0812)

Summary

Vitamin D is essential for the formation, growth, and repair of bones and for normal calcium absorption and immune function. It is obtained primarily through exposure of the skin to ultraviolet radiation in sunlight, but it can also be obtained from some foods and dietary supplements. Some studies suggest that higher intakes of vitamin D from food and/or supplements and higher levels of vitamin D in the blood are associated with reduced risks of some types of cancer. The goal of this trial is to determine whether a high dose of vitamin D3 (cholecalciferol) can change risk factors associated with breast cancer, such as breast density and a protein called Ki-67. To be eligible, participants must be at high risk of developing breast cancer because they have a past history of DCIS or LCIS, have a known genetic mutation, or have a Gail risk score >1.67%.
This is a Phase II trial

What's involved:

Participants will be randomly assigned to 1 of 2 groups:

Group 1: Experimental

  • High dose vitamin D3 (cholecalciferol) my mouth once a week for 1 year
  • Vitamin D by mouth daily for 1 year

Group 2: Control

  • Placebo by mouth once a week for 1 year
  • Vitamin D by mouth daily for 1 year

Additional procedures:

Blood samples, mammogram, questionnaires, possible breast biopsy

Trial length:

1 year

Post-trial follow-up:

Followed up at 1 and 12 months

Sponsor:

NCI

More information

View eligibility criteria and additional trial information: Cancer.gov (PDQ®) [Mar 21, 2012]   ClinicalTrials.gov

Related links:   NCI: Vitamin D and Cancer Prevention   NCI: The Breast Cancer Risk Assessment Tool

http://www.breastcancertrials.org

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Mar 28 2012 at 8:40pm
This is just my 2 cents on this clinical trial:

Vitamin D3 for High-Risk Women

High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer (SWOG-S0812).


I've learned that most of us dx with TNBC have extremely low levels of Vitamin D.  When I was first tested, my level was 19 (deficient).  I think it would be great if you could get into the study arm where you were getting the Vit D3.  If not, your health is way too important to remain in the study using a placebo.  The most important thing, in my opinion, is to increase your Vitamin D levels to where they are adequate.  A placebo won't do that and you could be wasting valuable time with your health.

Donna



DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Grateful for today Quote  Post ReplyReply Direct Link To This Post Posted: Mar 28 2012 at 10:24pm
Hi Donna and all,

Am confused.
What am I missing?
It does seem anyone on the study can take a multivitamin as long as it does not have more than
400 IU Vit D.
However, the study is for baseline level of less than or equal to 32.
Cancer prevention aside, why would there be a study to include people with Vit D less than 32 to
not have more than 400 IU Vit D given what is known today about Vit D?

Does any one know if there is a place/research oversight group-agency if one wanted to ask
questions on the safety/potential harm in such a clinical trial like this?     (That is, places other
than where the clinical trial is being done).

Thanks.

Grateful for today.............Judy

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Mar 28 2012 at 11:02pm
Judy,

I found more info-

High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer

Objective:   To assess whether mammographic density is reduced in premenopausal women at high risk of breast cancer taking high-dose vitamin D3 (oral cholecalciferol 20,000 IU weekly) vs placebo for 1 year.  RATIONALE: Cholecalciferol may prevent breast cancer in premenopausal women.
PURPOSE: This randomized phase II trial is studying how well cholecalciferol works in preventing breast cancer in premenopausal women.

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 04 2012 at 4:16pm
Comparing 2,000 IU/day vs. 5,000 IU/day vitamin D supplementation
March 29, 2012 -- John Cannell, MD

Dr. Terry Diamond and colleagues of St. George’s Hospital in New South Wales just published the first head-to-head comparison of 5,000 IU/day to 2,000 IU/day. Remember, the Food and Nutrition Board says 4,000 IU/day is the upper limit, but Dr. Diamond knows the pharmacology of vitamin D well enough to know that quite a few people will still have inadequate levels at 4,000 IU/day.

He recruited 30 patients with vitamin D levels less than 20 ng/ml and put half on 5,000 IU/day and half on 2,000 IU/day for three months. He measured a number of things, the most important of which was muscle strength.

Diamond T, Wong YK, Golombick T. Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporos Int. 2012 Mar 16.


After 3 months of 2,000 IU/day the vitamin D levels averaged 30 ng/ml (75 nmol/L), meaning about half the patients were still vitamin D deficient. Not so with the 5,000 IU/day group. The average vitamin D level was 45 ng/ml (114 nmol/L), right in the “natural range.” In addition, 93% of the patients had levels higher than 30 ng/ml compared to the 2,000 IU/day group, where only 45 % had levels above 30 ng/ml. Remember, one of the problems with daily dosing is that you must rely on the patient to take their medication. As an old GP, I am here to tell you not all patients take their meds; the ones that get me are the ones who look me straight in the eye and tell me something I know is not true.

In Dr. Diamond’s well-designed study, changes in grip strength compared to baseline were very significant, while the improvements in timed tests of sitting to standing and the 6-meter walk test also improved, but not significantly. What surprised me was that the improvements did not vary with dosage. That is, the 2,000 IU/day had the same improvements in grip strength as did the 5,000 IU/day, meaning muscle strength improvements are the most dramatic at changes in lower ranges of vitamin D levels. By that, I mean if your level is 5 ng/ml to start out and you get to up to 20 ng/ml, your percentage improvement in muscle strength will be much more dramatic than someone who went from 20 to 35 ng/ml.

I am glad to see Australians using daily dosing of vitamin D. Many of the “Stoss” doses, 100,000 IU/month or 600,000/year are not physiological, and are dangerous. Vitamin D was made every day in the skin of our ancestors and we should strive to replicate such dosing schedules. How much do we need? To quote Dr. Diamond, “This study demonstrates that the administration of oral vitamin D at 5,000 IU daily is superior to 2,000 IU daily for 3 months to treat mild to moderate vitamin D deficiency.”
http://blog.vitamindcouncil.org/2012/03/29/comparing-2000-iuday-vs-5000-iuday-vitamin-d-supplementation/
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mindy555 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 04 2012 at 5:28pm
I'm still baffled by doctors who are otherwise extremely savvy and don't place much regard on Vit D-3 testing and proper dosing.  Speaking from my own experience...

Very good info, Donna.. thank you!

Mindy 
Dx July 2011 56 yo
Stage I IDC,TN,Grade 3
Grew to Stage IIa- No ev of node involve- BRCA1+ chondroid metaplasia
Daughter also BRCA1+
Mass grew on Taxol
FEC 6x better
BMX 3/19/12 pCR NED
BSO 6/2012
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MsBliss Quote  Post ReplyReply Direct Link To This Post Posted: Apr 05 2012 at 2:45pm
Thank you Donna.  I'm always interested in what the Vit D Council has to say....too many oncologists are ignoring this important matter to our detriment.  It's inexcusable.
Dx 3/09 stg1 BRCA neg, 1.4cm IDC + 7mm DCIS, ki67 70 -90%, lump w/re-ex for margin, no chemo/no rads due to delays from secondary health issues; SonoCine every 6 months plus CAM interventions
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 09 2012 at 1:07pm
We've had some discussions on this thread about Magnesium so I wanted to post some helpful suggestions from KatieMarie from another thread.

Originally posted by KatieMarie KatieMarie wrote:

I was just reading on another post about Donna not being able to sleep.
 
I have been helped so much by all of you, I am going to post what helped me in this situation, perhaps it can help someone else.
 
A little background:  we were searching for something to help our daughter with focus issues, we heard about epsom salt baths, which we have done but we are so busy in the evenings, we were having a hard time making sure she had time to soak. 
 
Magnesium is the "active ingredient" in epsom salt.  We didn't want an oral route for magnesium because we didn't want to deal with the gastrointestinal effects (makes things move along, perhaps sometimes too quickly).
 
In my research, I found Magnesium Oil, and how it helps with sleep issues too.  Well, was having trouble with that, so tried it too.  Success.
 
I have been AMAZED what life is like actually having a full nights sleep.  Going to sleep...eyes popping open seven hours later.  I am still amazed.  I lay there and thank God for a good nights sleep.  It's a precious commodity, huh?
 
I had gone so long waking up several times a night, looking at the clock, sometimes going back to sleep, sometimes laying there an hour or two.  Always needing or at least wanting an afternoon nap.
 
I am of the mind that it is best to get our nutrients from our food, but after cancer and learning more about where we get our foods, I believe our soils are depleted of the good things we need anymore.  I believe we have to take extra measures, such as the Vitamin D situation.  Maybe the chemo, maybe the stress depletes us all of Magnesium, I dunno.  Maybe I am just old. Smile  (Donna, I do not think you are old!)
 
I tried the Ancient Minerals on Amazon.  It is about $23.  There is a cheaper brand but I got the more expensive one, I may reevaluate later.
 
Additionally, I have heard good things about SlowMag, an oral supplement.  It uses the good, bioavailable form of Magnesium, which is Mag chloride.  If you are taking Mag oxide, your body probably isn't getting much.  I was on 100% rda of Mag oxide, and when I added the Mag chloride, that is when I started sleeping through the night.
 
A couple things amazed me:  I went to bed one night, hubby already in bed asleep and snoring and I STILL fell asleep.  Also, my seven year old daughter convinced me to let her sleep with me while hubby was on a work trip.  This is usually a torture session with her rolling around kicking me with me laying awake alll night but we both had our Mag Oil and we both slept all night.
 
Okay, that's about it.  I probably sound like a sales person for this stuff, I am sorry about that.  I get excited about things I find and want to share with everyone.  If you have any questions, I would be happy to try to answer.
 
Blessings to all of you!!
Katie

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mindy555 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 09 2012 at 11:47pm
Good post from Katie!  I have to say, you're wasting your time and money taking magnesium oxide..which is the form that seems to be on all the drugstore shelves. The bioavailability is clearly inferior. There are much better forms of magnesium.  I'm not sure there's a "best"- although it's worth a little research, trial & error.  Currently I'm taking SOLGAR Brand Magnesium Citrate.  There may be forms with as much or more absorbency. 

I've always found Life Extension org a really good source for information.

From the research here and my own, I believe this is an important mineral to take in tandem with Vit D-3 & calcium for all of us with TN.  It has many advantages as mentioned; help with restful sleep and relaxation.  For me,  relief from constipation was an added benefit.   There are some who like to use certain forms of magnesium salts / minerals topically (like above) for absorption. 
Dx July 2011 56 yo
Stage I IDC,TN,Grade 3
Grew to Stage IIa- No ev of node involve- BRCA1+ chondroid metaplasia
Daughter also BRCA1+
Mass grew on Taxol
FEC 6x better
BMX 3/19/12 pCR NED
BSO 6/2012
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mindy555 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 10 2012 at 12:01am
One out of many articles on magnesium..

Mg citrate found more bioavailable

than other Mg preparations in a

randomised, double-blind study.

Walker AF, Marakis G, Christie S, Byng M.

Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, Reading, UK. a.f.walker@reading.ac.uk

Abstract

Published data on the bioavailability of various Mg preparations is too fragmented and scanty to inform proper choice of Mg preparation for clinical studies. In this study, the relative bioavailability of three preparations of Mg (amino-acid chelate, citrate and oxide) were compared at a daily dose of 300 mg of elemental Mg in 46 healthy individuals. The study was a randomised, double-blind, placebo-controlled, parallel intervention, of 60 days duration. Urine, blood and saliva samples were taken at baseline, 24 h after the first Mg supplement was taken ('acute' supplementation) and after 60 days of daily Mg consumption ('chronic' supplementation). Results showed that supplementation of the organic forms of Mg (citrate and amino-acid chelate) showed greater absorption (P = 0.033) at 60 days than MgO, as assessed by the 24-h urinary Mg excretion. Mg citrate led to the greatest mean serum Mg concentration compared with other treatments following both acute (P = 0.026) and chronic (P = 0.006) supplementation. Furthermore, although mean erythrocyte Mg concentration showed no differences among groups, chronic Mg citrate supplementation resulted in the greatest (P = 0.027) mean salivary Mg concentration compared with all other treatments. Mg oxide supplementation resulted in no differences compared to placebo. We conclude that a daily supplementation with Mg citrate shows superior bioavailability after 60 days of treatment when compared with other treatments studied.

Another article which may be of interest:



Dx July 2011 56 yo
Stage I IDC,TN,Grade 3
Grew to Stage IIa- No ev of node involve- BRCA1+ chondroid metaplasia
Daughter also BRCA1+
Mass grew on Taxol
FEC 6x better
BMX 3/19/12 pCR NED
BSO 6/2012
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 10 2012 at 8:47am
Racial Differences In Breast Cancer Risk Influenced By Vitamin D
American women of African ancestry are more likely than European Americans to have estrogen receptor (ER) negative breast cancer. There continues to be discussion about the role of low levels of vitamin D in the development of breast cancer for these women. New research published in BioMed Central's open access journal Breast Cancer Research has shown that specific genetic variations in the vitamin D receptor (VDR) and in CYP24A1 (responsible for deactivating vitamin D) are associated with an increase in breast cancer risk, particularly for ER negative breast cancer, for African American women. 
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote sabinecalifornia Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2012 at 3:05pm
I got my lab results back 1 week ago. I had mny Vitamin D level tested and it came back with 32. I take Vitamin D3 1.000 IU every day. I live in Southern California and I am outside in the sun for 30min to 1 hour every day. Why is my Vitamin D level so low? How much Vitamin D 3 can I take on a daily basis.
 
Sabine
DX TNBC 7/11 @ age 50, Stage 2A Grade 3, 1/19, LE/AD 8/11, BRCA1/2 neg.,
4 A/C, 10 Taxol, 2 Abraxane due to allerg. react. to Taxol, fin 3/12. 33 Rads 6/12. NED CT 8/12, 10/13, 10/14
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2012 at 3:07pm
Sabine,

Many of us take 5,000 IUs a day.  Try increasing it and retaking the test in a few months.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote sabinecalifornia Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2012 at 3:16pm
Thank you Donna for your quick responds. I will take 5.00 IU a day, my next lab is in August. I hope you are doing fine. Have a great Memorial Day weekend. Enjoy the sunshine.
 
Sabine
DX TNBC 7/11 @ age 50, Stage 2A Grade 3, 1/19, LE/AD 8/11, BRCA1/2 neg.,
4 A/C, 10 Taxol, 2 Abraxane due to allerg. react. to Taxol, fin 3/12. 33 Rads 6/12. NED CT 8/12, 10/13, 10/14
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Post Options Post Options   Thanks (0) Thanks(0)   Quote sabinecalifornia Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2012 at 3:17pm
I meant 5.000 IU
 
Sabine
DX TNBC 7/11 @ age 50, Stage 2A Grade 3, 1/19, LE/AD 8/11, BRCA1/2 neg.,
4 A/C, 10 Taxol, 2 Abraxane due to allerg. react. to Taxol, fin 3/12. 33 Rads 6/12. NED CT 8/12, 10/13, 10/14
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mindy555 Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2012 at 3:19pm
FINALLY some doctors; PCPs, internists, oncologists, etc. ARE understanding the importance of Vit D-3 for us.   I take 7,000 IUs daily (which got a high 5 from my GYN when he asked)

I need more than kudos.   D levels checked next appt. mid June.
Dx July 2011 56 yo
Stage I IDC,TN,Grade 3
Grew to Stage IIa- No ev of node involve- BRCA1+ chondroid metaplasia
Daughter also BRCA1+
Mass grew on Taxol
FEC 6x better
BMX 3/19/12 pCR NED
BSO 6/2012
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 03 2012 at 6:50pm
Interesting article on Vitamind D and TB vaccine.  Quote:  "The connection between vitamin D and tuberculosis was established long ago, when ancient societies sent people with TB into the sunlight for therapy. Increasing vitamin D levels is known to wake up cells and trigger an immune response whenever infection or inflammation is present."

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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