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TNBC Vaccine Clinical Trial

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Eliza500 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Eliza500 Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 2:01pm
VERY EXCITING NEWS FROM CLEVELAND TNBC VACCINE TRIAL
The bloodwork analysis is back from the first four participants, and TWO OF THEM RESPONDED.  Sadly, my daughter was not one of them.  But she was very fortunate to have the opportunity to participate.
 
My understanding is that if even one of the first nine participants responded, it meant they would add  more people...and that if four or more of the first 18 responded, they would add 20 more.  So keep calling and writing..and hoping.
Mother of Cindy, 39, diag. 2/10 Stage 2B Grade 3, double mastectomy with recon, dose dense ACT plus Avastin clinical trial, Rads, Pulmonaryu lesion removed11/10 benign, clinical trial TNBC vaccine
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Charlene View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Charlene Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 2:41pm
Can your daughter continue to participate?  Is there a chance that additional vaccines might boost her immunity in the future?  Or, is her participation ended?  Thanks for the update and best wishes for the future.
Charlene
DX 3/10 @59 ILC/TNBC
Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision
SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads
3/14:NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Eliza500 Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 2:48pm
Hello, Charlene.  No, she is done....the women whose bloodwork DOESW show immunity go back in a year for two booster shots. This is a stage 0 clinical trial-a tiny number of participatns wiith a very limited goal: discover whether this specific regimen can create or boost immunity to the MUC1 protein which is almost almways found in TNBC tunmors. If this is successful, future studies can investigate what affect, if any, vaccination has on recurrence rates and timeframes, overall survicval, and a host of other things.
 
But for right now...the really good news is that something NEW is in the pipeline and the VERY early stage clinical trial has had some success.
Mother of Cindy, 39, diag. 2/10 Stage 2B Grade 3, double mastectomy with recon, dose dense ACT plus Avastin clinical trial, Rads, Pulmonaryu lesion removed11/10 benign, clinical trial TNBC vaccine
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Charlene View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Charlene Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 3:42pm
Thank you again!  I am sorry that your daughter was not one of the participants who responded.  I admire your positive attitude and concern for others.
Charlene
DX 3/10 @59 ILC/TNBC
Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision
SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads
3/14:NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 3:51pm
That's terrific news for the ladies who had some success and for the vaccine itself. Now if they can just match up the type of tumor with the success it will be splendid.
 
Charlene, I really didn't mean to come across quite so cranky, sorry about that. What I was trying to convey by the retail remark is that research facilities are not set up to do any kind of, for lack of a better brain process on my part, hand holding. I've been to close to half dozen different cancer facilities and I've noticed from all of them a certain lack of business type responses...no follow up emails or method to answer my questions. It took me a long time to figure out that they can't take the time to educate me on things or sit and read with me the new things coming down the pike.
 
My first onc told me that she would answer 3 emails and no more.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 4:50pm
Eliza,

I'm sorry your daughter didn't show a positive result from the trial, but it is indeed good news that some of the participants did.  Since we know that TNBC is at least 6 sub-types, maybe they can figure out if the positive results gravitate to a certain sub-type.  I know Phase 0 is just the opening of a door, but we can use all the positive stories of hope for us.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Marlaina816 Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 9:17pm
Is this clinical study still going on? I'd like to participate if possible, who do I contact??? Has anyone else on the board participated in it?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Eliza500 Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 9:45pm
Hello, Marlaina. This study is for people who hve completed surgery, chemo, and radiation.  IT is technically still taking participants, but my understanding is that the blood tests of at least two more of the current participants must show immunity in order for them to add another group of participants--I think it will be 17.
Mother of Cindy, 39, diag. 2/10 Stage 2B Grade 3, double mastectomy with recon, dose dense ACT plus Avastin clinical trial, Rads, Pulmonaryu lesion removed11/10 benign, clinical trial TNBC vaccine
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 10:04pm
Eliza,

Maybe if this trial makes it beyond Phase 0, it will open to more people.  I don't know what quantifies a trial to move it into Phase 1.  It seems there are a lot of interest from members of this forum.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Aug 15 2011 at 10:31pm
Marlain, if you go back to the beginning of the thread and read through you'll find contact sources as well as a good discussion. Good luck to you.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Sep 06 2011 at 8:19pm
I wanted to let you know that I showed this trial to my onc and she said they'd contact the coordinators.  I just got an email from her that they tried but got no response either.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote LauraT Quote  Post ReplyReply Direct Link To This Post Posted: Sep 06 2011 at 8:23pm
Frustrating.

Laura
DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Sep 10 2011 at 12:17pm
OK, I think this is the reason we've not heard much about this trial.

http://www.wkyc.com/news/article/205986/7/UH-doctor-works-on-Triple-Negative-breast-cancer-vaccine

In 2008, Dr. Barr, an oncologist at University Hospitals, tried developing a vaccine that allows one's own immune system to pinpoint and kill cancer cells for women who have suffered Triple Negative breast cancer.

Dr. Barr found a link between this type of cancer and a protein called MUC-1. This discovery green-lighted a study that focused in on protein in breast cancer cells.

The vaccine would prevent a reoccurrence of Triple Negative breast cancer.

In October 2010, the first vaccine was administered and none of the patients developed immunity, however, flu-like symptoms, along with joint discomfort, was a common complaint and Barr decided to place the study on hold.

Dr. Barr has made some changes to the study and hopes to begin a new phase in the future.

"We are keeping our fingers crossed at this one," he said.

WKYC-TV


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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