Using metformin?
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Topic: Using metformin?
Posted By: tania
Subject: Using metformin?
Date Posted: Feb 16 2011 at 4:11pm
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I am interested in connecting with anyone who is currently taking metformin. I am aware of the large randomized trial, but am most interested in trying to get this prescribed for an "off label" use where I know for sure that I am getting the drug. The initial data is compelling and I am looking for find a medical doctor that supports this, will write the prescription and who will monitor me for possible side effects. Preferably in the greater San Francisco bay area. Oncologists recommend the trial only. An integrative doc of UCSF has prescribed for others, but has not been very encouraging of this approach for me.
Any input and information is most appreciated. thank you!
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Replies:
Posted By: cheeks
Date Posted: Feb 16 2011 at 4:18pm
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I have taken Metformin for my diabetes for the last 6 years - didn't stop me from getting TNBC - how is it supposed to help with breast cancer?
------------- Lump found 11/08 DX: 2/09 @52 TNBC L. Mast. 3/26/09, SN-, BRCA-, 4.5 cm (post surgical)T2NOMO Chemo: 4/09-10/09 Taxol x 12, A/C x 4, No rad.No recon. NED 1/17. New Primary right breast TN, 2/2018. |
Posted By: 123Donna
Date Posted: Feb 16 2011 at 4:23pm
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Tracy, one of our members, is in a Metformin trial. Here's the thread talking about it. http://forum.tnbcfoundation.org/metformin-clinical-trail-info_topic7434.html?KW=metformin - http://forum.tnbcfoundation.org/metformin-clinical-trail-info_topic7434.html?KW=metformin ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: mainsailset
Date Posted: Feb 16 2011 at 4:26pm
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Donna you beat me to it, was wondering why my post wouldn't go through! As we all know there is no magic bullit to prevent getting bc, and certainly no one would suggest that metformin has the ability to be that bullitt, but the studies have been suggesting a strong connection when metformin is used to improve the efficacy of chemo itself when given at the same time.
------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: 123Donna
Date Posted: Feb 16 2011 at 4:35pm
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Mainy, Ha, maybe we're twins? ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: mainsailset
Date Posted: Feb 16 2011 at 4:37pm
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I wish! ------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: TracyAMac
Date Posted: Feb 16 2011 at 5:08pm
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Hi Tania, Cheeks, Donna and Mainy Many times I have been asked why can't I just get Metformin prescribed to me by my dr/onc/whoever? If you ask, the answer is that is usually given is it would be crossing a medical-ethical line as Metformin has not yet been approved for BC treatment or prevention in most if not all areas. The clinical trial environment has strict eligibility criteria, pre-trial blood screening tests and obligations to continued testing and check ups during the 5yr trial that are submitted to the central trial investigators so that they can consistently monitor and assess any correlations between the trial drug and BC recurence. If the are huge success or failures during the trial they might "unblind" the study before the 5 years are up. Mainy, I haven't heard about Metformin being administered with chemo. - is that part of clinical trial or something else? I was also on a small pre-surgery Metformin trial for a few weeks (not double blind) to see if it could shrink or slow the growth of tumors before surgery. . Even though the group size was small I was told that the results of the trial will not be published for a couple of years - I hate waiting!!! Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: tania
Date Posted: Feb 16 2011 at 5:32pm
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The research abstracts I have muddled through suggest that it can make chemo more effective (with the exception of platinum based drugs, which it can possibly diminish the effects of). The large trial (CA-32 or MA-32, I think it is referred to) is for folks who are completely done with chemo. I am not sure I understand exactly how it works, but metformin may have an anti-angionesis effect. There are some studies that show it is most effective in TNBC lines (in mice and in culture - no human trials). All looks good, but this is why I am interested in finiding someone with medical credentials to try and help me make sense of the studies and see if the data really is compelling enough to try and "go rogue" with this one and get the drug outside of the randomized trial. I know of at least one oncologist at Mt. Sanai who is writign prescriptions off label as he beleives the possible benefits far outweight the risks. He won't take me on as a patient/consult, though.
Cheeks - the initial finding was discovered at MD Andersen that showed that diabetics on metformin showed better response to chemo than diabetics on something else. Then that led to looking at the drug's effect on non-diabetics.
I am happy to send the abstracts to anyone interested in reading. Just send me your email address. I have electronic versions but no online links.
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Posted By: 123Donna
Date Posted: Feb 16 2011 at 5:34pm
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Tracy, I was told a while back the same thing you just said. Prescribing Metformin for breast cancer patients outside of a trial, would be considered off-label for the drug and most doctors won't cross that line. This could all change with trials like the one you're in if Metformin is approved for use for breast cancer. The tough part is waiting for these trial results to be released! Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: tania
Date Posted: Feb 16 2011 at 5:39pm
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Five years is a long time to wait for those of us trying to get this behind us and never see it come back! I will probably sign up for the trial if I can't find a doc who feels strongly enough about this.
Donna - I am also on a Gem/Carbo/PARPi trial. I am at Stanford for the early stage, phase II trial.
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Posted By: dmwolf
Date Posted: Feb 16 2011 at 5:45pm
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Ok, Tania - fess up: what do you do for a living? :) d (also a science geek) *why won't the Mt Sinai guy pony up? ------------- DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10. |
Posted By: 123Donna
Date Posted: Feb 16 2011 at 5:45pm
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Tania, We have a couple of threads for those of us on the Parp trials. Maybe you can give others an update on your experience with it so far. Here's the links: http://forum.tnbcfoundation.org/good-scans-on-parp-trials_topic7810.html - http://forum.tnbcfoundation.org/good-scans-on-parp-trials_topic7810.html http://forum.tnbcfoundation.org/very-disappointing-news-iniparib_topic7864.html - http://forum.tnbcfoundation.org/very-disappointing-news-iniparib_topic7864.html Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: johnmc
Date Posted: Feb 16 2011 at 6:34pm
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Hello all,
My wife - tnbc with mets to mediastinum - has been on metformin for around a year now. Current dose 500mg twice a day.
When studies first came out suggesting metformin may have beneficial effect on breast cancer, I mentioned this to our oncologist and suggested that because my wife was TNBC and because metformin is so inexpensive and because there were no real good treatments, akin to herceptin,for TNBC, Might it not be worth trying. He agreed. We started at 500 mg once a day for awhile to make sure my wife could tolerate and now she is on 500mg twice a day. She is not diabetic and has no side effects on the drug. She also is not overweight.
Parenthetically, drugs are used ALL THE TIME -for off label reasons. For example, beta blockers and calcium channel blockers are used for migraine prevention, antidepressents are used for chronic pain,sleep disturbances and fibromyalgia. Beta blockers are used for certain tremors. These are all off label uses. These uses are not illegal nor unethical. Many of you may have taken Claritin when given Neulasta shots. This works terrifically for the bone pain of Neulasta and is fairly widely used. This also is an off-label use. That would be an example to share with oncologist who says "I can't do it" because "it's unethical".
I would suggest to your oncologist that if you would like to try metformin to discuss trying it at a low dose and increasing if tolerated. Tell them you would agree to sign a statement stating you would not hold them responsible for this off-label use should you experience side effects. Most oncologists are not familiar with using metformin. This reasonably would make them nervous about using it. Possibly the oncologist would be okay if a clearance was gotten from your family doctor, but I think a release would go a long way in calming malpractice nervousness. The statement I like ( I did not invent it) - "the side effect of metastatic TNBC is death"............that kind of puts it in perspective.
One VERY IMPORTANT FACT about metformin. If you have any decrease in kidney function - can be monitored by BUN/creatinine levels - metformin should NOT be used. Certain chemos can cause kidney problems so these tests should be monitored before and during metformin use. This is very important and something an oncologist may not be aware of. Remember they don't use metformin on a usual basis, so they probably feel uncomfortable using it.
So in a nutshell, it's not so much "it's unethical" - it's more I'm not used to the drug and I'm uncomfortable using it, which you can understand. BUT working with your FP, monitoring kidney function on a regular basis, signing a waiver holding the oncologist harmless - all these would probably help grease the wheels if you want to go the metformin route.
I hope some of this helps. I truly believe for my wife- that if there's any chance that taking metformin will help keep her cancer at bay - it's worth it.
John
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Posted By: 123Donna
Date Posted: Feb 16 2011 at 7:24pm
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John, Thanks for your perspective and guidance. I never thought about the anology of off-label use like Claritin for the Neulasta shot. It makes sense and so does your suggestions for talking to our oncs. In light of the most recent research from the Jefferson KCC, metformin is in the news again. http://www.eurekalert.org/pub_releases/2011-02/tju-jrp021011.php - http://www.eurekalert.org/pub_releases/2011-02/tju-jrp021011.php Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: TracyAMac
Date Posted: Feb 16 2011 at 7:32pm
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Thanks Tania for your info - good to know John you raise some compelling points for the off label use of Metformin and I agree many doctors are unaware of the drug. What I and others have been told is that the "ethical" issue for many doctors is that prescribing a med. that has primarily used for only one specific disease, especially one that is has not had much prior research for expanded use - it's not backed by a pharma., thus the low cost- and knowing that that controlled trials are currently in progress for this drug is crossing a professional line. It is unfortunate when we look at how fast Viagra went from being used for heart issues to approval for its current main use. Recommending over the counter meds. to manage side effects or prescribing more generalized drugs that have been medically proven to help with side effects is viewed as something different.. Also, in some hospitals, especially those with a research/teaching component they usually have to "follow the book" - no exceptions without going through a formal appeals process. My onc. had to do this to get extra cycles of TC for me because I could not have Adriamycin, having received the life time limit of it for another cancer 30 years ago. Even with two different tumors (one metaplastic) and Li Fraumeni Like Syndrome, he had to jump through hoops. Thankfully, it was approved - in a non research/teaching hospital oncs. can do what they want in terms of extra cycles- hopefully within protocol guidelines! In addition to the potential kidney impact, Metformin can cause serious diarrhea and weight loss if not taken at the right dose and/or gradually increased so your advice about starting on a low dose is important. I admire what you and your wife are doing to fight this terrible disease. Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: johnmc
Date Posted: Feb 16 2011 at 11:03pm
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Hi Tracy,
I'd like to respond to a few of your points.
Metformin - which has approval for treatment of type II Diabetes- is already used "off-label" in a condition called polycystic ovarian syndrome (PCOS)and has been for years now, so the precedent for off-label use for this specific drug is already there.
I don't know about Canada, but I assure you that no doctor in an outpatient setting - as most oncologists are in the US - would have to jump through any hoops or fill out any particular forms to write a prescription for metformin. The RX could be filled in any local pharmacy and no questions would be asked by anyone.
IF you were prescribing in an inpatient setting, then you MIGHT have to fill out some forms IF the drug was controlled in some way (eg newest restricted use antibiotics) OR if the drug was not on formulary. However in an outpatient setting there is no such oversight and as I said in my previous message many drugs are used off-label already and there is no restriction against doing so. This is not to say a drug could be used willy-nilly without any consequences. There should be scientific rationale for the use and with proper judgement and monitoring - otherwise malpractice could be alleged if untoward consequences occurred. Certainly there is a rational for the use of metformin in someone with metastatic TNBC but then the potential for side effects would have to be weighed against the possibility for benefit. One would have to go into the use with open eyes and proper understanding of potential side effects. Cost with metformin is not an issue. You can probably get a month supply at WalMart for $4.00 here in the US.
I can give you another example of "off-label" use that would apply specifically to TNBC. Avastin was approved for met breast cancer "when used with Paclitaxil". That FDA approval as you may know has been rescinded. Sanofi is appealing and while the appeal is going on, Avastin is still covered under many insurances for women who have already been receiving it. Now I know positively that there are women with met TNBC who are kept on AVastin after they complete the AVastin/Taxol treatment in the hope that Avastin alone will keep them disease free. And in fact there is a woman on the Inspire board who has been very vocal on Avastin - started the big petition to keep it approved- who has been on Avastin 2 and 1/2 years and is still NED. She is certainly not alone.
The NCCN guidlines for 2011 and backed by the top centers in the US, still lists AVastin and Paclitaxil as a recommended treatment in met BC.
But here's the point I'm trying to make. Avastin is being used ALONE -as MAINTENANCE therapy- after they go into remission- in those women who respond to it and tolerate it -even though the true indication is to be used "with Paclitaxil".
So technically speaking this is an "off-label" use of Avastin. It is going on because oncologists have found that some women can remain NED once they are put into remissioin by staying on AVastin alone and because some of these women tolerate it well. IT's already going on and it's technically an "off-label" use and the drug is much more dangerous,far less widely studied and 1000xs more expensive than metformin -but it's being done for the most ethical reason of all - to try and keep the women alive.
Keep the fight going !
John
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Posted By: johnmc
Date Posted: Feb 16 2011 at 11:07pm
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Donna,
Thanks for the posting re:Jefferson Kimmel Center findings
John
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Posted By: TracyAMac
Date Posted: Feb 17 2011 at 12:27am
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Thanks John for your additional notes on this topic. I believe it is the same here in Canada in terms of doctors/family doctors and being able to prescribe Metformin on an out patient basis. My "jumping through hoops" example is re what usually happens in research/teaching hospitals where there are very strict requirements to follow protocols. As I mentioned, other hospitals often have more latitude. Based on what we know about Metformin, I wish I could get a script for it and I would be willing sign a waiver as you suggested. I and many people I have heard from have not been able to get it so for me, the trial is the next best thing. If I get mets., I will be jumping and screaming for it or whatever best is available at the time to fight the good fight. It is frustrating that there seems to be so few trials focused on TNBC and other aggressive forms of BC. When we find one, and qualify for it, the trial is often long and randomized. The one I am on is not specific to TN but I am happy they are stratifying participants into different groups including those of us who had tumors were not hormone receptive. Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: 123Donna
Date Posted: Feb 17 2011 at 7:37am
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Tracy and John, I've looked at some of the clinical trials for metformin. Most of them are for early stage breast cancer and preclude anyone with recurrent or metastatic disease. I couldn't find a study for women like me or John's wife. It's unfortunate they are not looking at studies for more advanced bc or specifically the effects of metformin and TNBC. Sigh, where are the studies for TNBC? Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: 123Donna
Date Posted: Feb 28 2011 at 8:31pm
Metformin suppresses metastasis of triple negative breast cancer cellsLast updated: December 5, 2010
http://foodforbreastcancer.com/news/metformin-suppresses-metastasis-of-triple-negative-breast-cancer-cells - http://foodforbreastcancer.com/news/metformin-suppresses-metastasis-of-triple-negative-breast-cancer-cells ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: johnmc
Date Posted: Feb 28 2011 at 10:28pm
| Thanks for the posting Donna! |
Posted By: outnumbered
Date Posted: Mar 01 2011 at 10:17am
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Just got back from C4YW and the metformin thing did come up a little. Nothing too specific and nothing more to add to what you all have posted. However, a lightbulb went on in my head and I am intrigued. As some of you know, I have been baffled by the fact that I am BRCA1+ as is my mother, however, she has not developed any cancer. Now I know the BRCA1+ puts us at 80% lifetime risk and perhaps she is in the 20%, or perhaps (God Forbid) its a not yet scenario, but I have nonetheless been intrigued. Well, my Mom has been on metformin for many years. Although it did not prevent anythig in Cheeks' case, perhaps it did for my Mom. Or maybe its a preventative for BRCA+ tnbcers. I know its a stretch, but why not?
Anyway, I have written an email to the contacts on the trial. Lets see if I get any response. ------------- ~Sara DX @ age 40 6/24/08 Stage 1 Grade 3 BRCA1+ 187delAG BMX (nipple-areola-sparing) 8/5/08 Redo BMX (remove nipple and areola) w/ Lat Flap 7/6/09 BSO 9/3/09 NED since 08/05/2008 |
Posted By: mainsailset
Date Posted: Mar 01 2011 at 10:24am
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Sara, that is fascinating, fingers crossed you can get a response! ------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: 123Donna
Date Posted: Mar 01 2011 at 12:38pm
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Sarah,
Good news indeed. I can't help think there maybe some link and possibly help for us TNBCers.
Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: outnumbered
Date Posted: Mar 01 2011 at 2:25pm
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Here is the response I got...
Thank you for the email. It is not possible to state the exact role that metformin may have had in your mothers situation. However, a series of observational studies published in the past 5 years have reported reduced cancer incidence and/or mortality among diabetics who receive metformin (versus other drugs) to treat type 2 diabetes. While this data cannot be used to prove that metformin has a role in preventing or treating breast cancer, it does provide a rationale for evaluating metformin in well designed clinical trials such as MA.32. Best of luck with everything, ------------- ~Sara DX @ age 40 6/24/08 Stage 1 Grade 3 BRCA1+ 187delAG BMX (nipple-areola-sparing) 8/5/08 Redo BMX (remove nipple and areola) w/ Lat Flap 7/6/09 BSO 9/3/09 NED since 08/05/2008 |
Posted By: dmwolf
Date Posted: Mar 01 2011 at 3:12pm
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I like your new pic, Sara. :) d ------------- DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10. |
Posted By: outnumbered
Date Posted: Mar 01 2011 at 3:13pm
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Thanks... You do know what it represents, right? ------------- ~Sara DX @ age 40 6/24/08 Stage 1 Grade 3 BRCA1+ 187delAG BMX (nipple-areola-sparing) 8/5/08 Redo BMX (remove nipple and areola) w/ Lat Flap 7/6/09 BSO 9/3/09 NED since 08/05/2008 |
Posted By: 123Donna
Date Posted: Mar 01 2011 at 5:04pm
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No, please tell us.
------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: outnumbered
Date Posted: Mar 01 2011 at 5:23pm
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Well Donna, I know its been a while but it looks like you may be able to re-join the club now.
 She is the false alarm queen. At least that is exactly what I thought of when I bought her. All that talk months ago of ball gowns and tiara's....
------------- ~Sara DX @ age 40 6/24/08 Stage 1 Grade 3 BRCA1+ 187delAG BMX (nipple-areola-sparing) 8/5/08 Redo BMX (remove nipple and areola) w/ Lat Flap 7/6/09 BSO 9/3/09 NED since 08/05/2008 |
Posted By: 123Donna
Date Posted: Mar 01 2011 at 5:59pm
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Thanks Sarah. What a wonderful idea for the false alarms! So much easier than trying to fit into that ball gown and tiara. Hope to be back into that category soon. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: dmwolf
Date Posted: Mar 01 2011 at 7:53pm
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Oh my gosh, that is SO wonderful!! I should have guessed. :) love, d ------------- DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10. |
Posted By: 123Donna
Date Posted: Mar 01 2011 at 8:33pm
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Maybe you could provide a link where we can buy them for the false alarms:) I want one because I want all my future alarms to be false! Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: 123Donna
Date Posted: Mar 23 2011 at 7:26pm
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Constantine from the No Surrender Breast Cancer Survivor Forum was commenting on a question about IPT. In his reply, he touched on Metformin. Here's the excerpt: And mounting evidence is moving massively in the opposite direction, namely of finding that anti-glycemic agents like the anti-diabetic drug metformin (Glugophage), and anti-glycemic diets, are recurrence and metastasis risk-reductive, the reason being, in part as I have hypothesized and brought evidence to support, via influence over the primitive development molecular pathway known as MTOR, which as I have predicted, along with the Hedgehog pathway family and their intersection with cancer stem cells (CSC), is the focal point of an explosion of translational and clinical research bringing us closer to a cure for breast and other cancers. Deeply underlying pathways like mTOR and Hedgehog, Wnt, and Notch is, I predict, where we will find the answers. But in the present state of accumulated knowledge, robust scientific evidence speaks clearly: simplifying greatly, we want less, not more, insulin. http://www.nosurrenderbreastcancersurvivorforum.org/ - http://www.nosurrenderbreastcancersurvivorforum.org/ ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: 123Donna
Date Posted: Mar 24 2011 at 6:25pm
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I've asked about Metformin and will probably start taking it next month after I'm finished with chemo. Besides reducing insulin levels, I was also advised to eat an anti-inflammatory diet. Try to go as much Vegan as possible and stick with fish or chicken. Only eat red meat on occasion but not every day. I've made an appointment with a Dietitian next month. And of course, exercise! The exercise part I've been lacking since this chemo is currently so fatiguing that just going to work and doing as much of my daily chores around the house just wear me out. I hope to feel better in a few weeks where I can be more active. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Littlesis
Date Posted: Mar 25 2011 at 7:07am
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Donna, How did you get your doctor to agree to prescribe Metformin for you? I showed my sister Natalie some of the studies I found here and from doing my own research and she seemed interested. I think she wants to ask her doctor about the Metformin studies, but is a little reluctant. She is only about half way through chemo at the moment. ------------- my sister age 44 at diagnosis now 45 dx 12/10 IDC TN, Stg 1 or 2 BRCA 1&2- (though fam hx) 4 DD Taxotere, 1 AC down 3 to go. |
Posted By: 123Donna
Date Posted: Mar 25 2011 at 7:19am
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Littlesis, I think she was aware of the trials and studies behind reducing insulin levels and the potential anti-tumor benefits. I mentioned it in an attempt to try anything to prevent a recurrence. We just don't have any adjuvant therapy besides chemo available to us. She also stressed to me the importance of diet (anti-inflammatory) and exercise. These last two I need to work harder on once I'm done with chemo. ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Littlesis
Date Posted: Mar 25 2011 at 9:50am
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Thanks Donna. I have some studies Natalie asked me to print off for her to share with her doctor next appt. Hopefully she's on top of the latest info out there. I know my sis is already working on her diet and wants to add more exercise to the mix when she's able. I'll keep you posted on how it goes. Nat starts A/C first week of April. ------------- my sister age 44 at diagnosis now 45 dx 12/10 IDC TN, Stg 1 or 2 BRCA 1&2- (though fam hx) 4 DD Taxotere, 1 AC down 3 to go. |
Posted By: 123Donna
Date Posted: Apr 15 2011 at 7:48am
New Test Identifies Cancer Patients To Benefit From 10p-A-Day Diabetes DrugScientists have developed a new test to identify patients with aggressive http://www.medicalnewstoday.com/articles/37136.php - breast cancer who could benefit from a 10p-a-day http://www.medicalnewstoday.com/info/diabetes/ - diabetes drug.They used a new method based on the food http://www.medicalnewstoday.com/info/cancer-oncology/ - cancer cells eat to predict which patients had a poor prognosis. Excitingly, they suggest these patients could benefit from metformin, a cheap and safe diabetes drug which is showing great potential as a cancer treatment. The findings come from the Breakthrough Breast Cancer Research Unit at the University of Manchester and Thomas Jefferson University in the USA and are published today in the journal Cell Cycle. Professor Michael Lisanti, from the Breakthrough Breast Cancer Research Unit at the University of Manchester, said: "We've shown that the saying, 'you are what you eat' holds true for cancer. The food cancer cells consume is crucial to how well a patient does and what treatment they need. "If cancer cells are consuming high-energy food, this makes a tumour more aggressive and harder to treat. However, patients could benefit from metformin, which cuts off this fuel supply. There is more work to do but this test could be an important new way of tailoring treatments to a patients needs, across a range of cancers." Professor Lisanti's team first looked at cells in the laboratory and fed them high-energy foods, known as lactate and ketones. They found which genes were expressed based on this fuel supply, and developed a gene signature based on this. They then looked at 219 breast cancer patients and studied which cancer cells fed on ketones and lactate. This food comes healthy cells nearby. They found those patients with cancer cells which consumed high levels of ketones and lactate were more likely to have their disease return, for it to spread to other organs and to die. The test combines the gene signature with the ketone and lactate food supply. This could show which patients are likely to have a poor prognosis - with those same patients potentially benefiting from metformin. Professor Anthony Howell, Director of the Breakthrough Breast Cancer Research Unit in Manchester, said: "We have discovered important new insights into how cancers feed themselves. It is a step towards having each patient get the right treatment for them - what we call personalised medicine. We are looking at a new way to separate patients based on who should respond well to the treatments we have, and who might need something different. "It is particularly encouraging that some of those treatments might already be in the doctor's drug cabinet, and cheap to prescribe. We have some way to go but we hope that drugs like metformin will be saving lives of breast cancer patients over the next few years." Source Breakthrough Breast Cancer http://www.medicalnewstoday.com/articles/222376.php - http://www.medicalnewstoday.com/articles/222376.php ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Littlesis
Date Posted: Apr 15 2011 at 8:51am
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Donna,
Thanks for posting this article. This is encouraging. I'm going to forward this link to my sister.
By the way, I've been meaning to tell you that I love your new picture.
Tonya ------------- my sister age 44 at diagnosis now 45 dx 12/10 IDC TN, Stg 1 or 2 BRCA 1&2- (though fam hx) 4 DD Taxotere, 1 AC down 3 to go. |
Posted By: Pink Warrior
Date Posted: Apr 15 2011 at 2:13pm
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I can't get my oncologist to prescribe it. =/ ------------- Dx:10/09,IDC Stg 2,Gr 3,TN BRCA 1&2 - Partial DD EC/AC Local recur 11/10 BMX 12/10 Right proph TC x 4 Rads x 33 9/11 Skin mets, mediastinal & hilar nodes Abraxane/Avastin |
Posted By: KatieMarie
Date Posted: Apr 24 2011 at 5:48pm
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Hi all,
I got my thyroid doc to prescribe metformin, 500mg twice daily. I brought in the articles about it related to breast cancer and the clinical trial. He had heard about it already. He is a family doc, but he definitely is a doc that thinks "outside the box." We are testing liver/kidney function in three months.
Blessings...
------------- IDC dx 4/24/09, Age 40 Two surgeries, three tumors: 1.4cm,4mm,2mm; Ki67=75 Stage 1, no node involvement, clean margins BRCA 1/2 negative, Chemo: AC dose dense then Taxol dose dense, then rads |
Posted By: 123Donna
Date Posted: May 04 2011 at 8:04am
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My onc is reluctant to prescribe metformin outside a clinical trial. Has anyone heard of the Canadian Metformin trial expanding to the states? Are there any other adjuvant metformin trials available today for breast cancer?
------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: LauraT
Date Posted: May 04 2011 at 9:13am
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My onc wouldn't give it to me either. I saw on the LBBC interview with Dr. Rugo that the trial in Canada would be expanding to the US "soon." I wonder what the timing is? Seems like soon is never soon enough!! I've thought about seeing how much it would cost to get my insulin levels checked. My grandfather was diabetic and he had throat cancer. ------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: 123Donna
Date Posted: May 04 2011 at 9:32am
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Laura, My onc told me the study will be expanding to the US, but there are some problems with distribution of the drug. I don't know what that means unless it could be that since the study is coming from Canada then the Metformin would have to be distributed across the border? Just speculating. I don't know what time frame "soon" is either, but hope to hear more about this study. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: TNinTN
Date Posted: May 04 2011 at 9:40am
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Susan's oncologist is running the metformin trial at Vanderbilt and suggested that Susan consider participating last February. At that time they were having some trouble getting the trial drugs across the border from Canada. It seems that customs didn't like the way the drugs were labeled. UGH! We will be going back to Vanderbilt tomorrow and hope to begin participation in the trial. I noted, however, that Hope Rugo's responses to questions on the LBBC site last month indicated that the trial was still not yet up and running in the U.S.
I did a clinical trials search at the breastcancertrials.org site and called TNBCF trials search and was dissappointed to learn that there are only three trials Susan is eligible for at this point (including the metformin trial which did NOT come up on either search). The two trials that came up on the searches were the MUC1 vaccine trial in Cleveland, OH and one for denosumab in Jacksonville, FL.
Does anyone have any thougths on these?
Martin ------------- Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11 |
Posted By: TracyAMac
Date Posted: May 04 2011 at 10:46am
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Hi - I will ask the Clinical Trial Coord. here in Toronto when I see her May 24 about status of getting the drugs to the U.S. Metformin has been around forever and is inexpensive, so I don't get why there is a problem. I understand that it does not have the backing of a pharma. - maybe that has something to do with it. One of the reasons I decided to go on the trial is because it was advertised to be a very large, Phase III North American wide study!!! The more that are on it the better - e.g. if good results are shown before the 5 year study is up, they could "un-blind" it earlier. Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: 123Donna
Date Posted: May 04 2011 at 11:19am
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Martin, I was given the same information about trouble getting the drug across the border. I hope they get this worked out soon so the trial will be available here. ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: LauraT
Date Posted: May 04 2011 at 11:38am
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Martin - I sent all my records up to Cleveland for the MUC1 trial but was not accepted (maybe because I have had scans that show something that needs to be followed). There is someone here whose daughter is participating in that one. It's probably in the TNBC talk section somewhere. Please let us know what you find out at Vanderbilt. I hope that you find something for her. When I finished treatment, there were no trials available for me and it was so frustrating! I missed one trial (up at Harvard) because it took them so long to get funding and get started. Now I am too far out from surgery.
Laura ------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: Charlene
Date Posted: May 04 2011 at 11:48am
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Martin,
I also sent all my records to the Cleveland trial for MUC1, but never heard anything back from them. I understand from the mother who has posted here a few times that the initial group that was accepted was extremely small, something like only 17, I think. If they had any success in building up the immunity, they planned to add more participants. Best wishes.
Charlene ------------- DX 3/10 @59 ILC/TNBC Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads 3/14:NED |
Posted By: LauraT
Date Posted: May 04 2011 at 11:57am
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Charlene - just realized you live in Atlanta. Hi Neighbor! I live in Johns Creek. Maybe we could meet for lunch someday.
Laura ------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: 123Donna
Date Posted: May 04 2011 at 12:28pm
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Tracy, We'd appreciate any information you can find out about this study being expanded to the US. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Charlene
Date Posted: May 04 2011 at 1:22pm
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Hi, Laura,
That would be fun! I am recently retired, so I have a pretty open schedule. I actually live in Douglasville, about 45 minutes from downtown Atlanta.
Charlene ------------- DX 3/10 @59 ILC/TNBC Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads 3/14:NED |
Posted By: LauraT
Date Posted: May 04 2011 at 2:23pm
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I'll send you a message so we can plan something! ------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: TNinTN
Date Posted: May 04 2011 at 4:47pm
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Our appointment tomorrow is in the afternoon and unfortunately it's a six hour round trip drive from where we live (which has been worth every minute). I'll let you know what we find out when we get back home tomorrow night.
Martin ------------- Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11 |
Posted By: Barbi
Date Posted: May 04 2011 at 5:45pm
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I was seen at my post chemo visit at Vanderbilt today. I am going to be seen in 3 months and my onc stated she hoped the metformin trial would be going by then so she could enroll me. Barbi
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Posted By: TNinTN
Date Posted: May 06 2011 at 12:30am
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Our oncologist told us today that the metformin trial is still on hold because the FDA won't allow the metformin or the placebo to come into the U.S. from Canada. She was hopeful, but not optimistic, that the problems would be resolved by July. Susan will no longer be able to participate after July because you must begin within one year of diagnosis. It is difficult to understand why the FDA is creating such a problem since metformin has been around for years. I wonder if politics are somehow involved??? Apparently no U.S. drug manufacturers were willing to produce the drugs for the study, but a Canadian company offered to do so. Now, for reasons that remain a mystery, the FDA won't allow them to ship the drugs here for the trial.
Argh!
Martin ------------- Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11 |
Posted By: 123Donna
Date Posted: May 06 2011 at 9:27am
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Martin, This is deeply disturbing to all of us looking for some adjuvant therapy to help prevent a recurrence. My understanding is Metformin is available in the US as we've heard others getting the drug off label. So I guess the problem is no US drug company is willing to participate in the trial and offer the drug for free and the FDA won't allow the Canadian manufactured drug cross the border? What a sad day for all of us. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: KenR
Date Posted: May 06 2011 at 11:55pm
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Please send me copies of the reports you mentioned. Thank you in advance! Ken
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Posted By: zoomommy2
Date Posted: May 06 2011 at 11:59pm
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Could the patient simply pay for the Metformin? It's not very expensive at all! Like Martin said, it's been around for years. My husband takes it!
Lee in Denver ------------- dx6/09,stageII,gr3,(L)mastectomy 7/09,ACx4,Taxolx7,Avastin study,gall bladder surgery 1/10,4/11 Stage 4, mets to lung, 4/11 Started Taxotere and Xeloda, 5/11 Taxotere stopped, off Xeloda |
Posted By: 123Donna
Date Posted: May 08 2011 at 9:44pm
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Lee, I think the problem is for the Canadian Metformin trial to be expanded to the US, they have to have consistency with the drug. So unless they can figure out how to get the Canadian Metformin distributed to the US, we're up the creek without a paddle! Unless the docs will prescribe this off label, it seems like it's not an option for us. When I was on the Bisphosphonate study and chosen to the Clodronate drug. It came from Canada and was only given to me through the clinical trial coordinator at my oncs office. When I had the recurrence and had to leave the trial, I had to return the unused Clodronate. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: 123Donna
Date Posted: May 21 2011 at 12:20pm
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http://www.nytimes.com/2010/11/30/health/30cancer.html?scp=1&sq=Dichloroacetate&st=cse&pagewanted=1 - http://www.nytimes.com/2010/11/30/health/30cancer.html?scp=1&sq=Dichloroacetate&st=cse&pagewanted=1 ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: TracyAMac
Date Posted: May 22 2011 at 10:43am
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On Tuesday I am seeing my onc and the Clinical Trial Coord. for the Metformin Trial - will push for answers and encourage solutions- I want my U.S. sisters to have access to this for many reasons.... Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: TNinTN
Date Posted: May 22 2011 at 11:48am
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Thank you so much Tracy. Time runs out for Susan to particpate in July. I hope for her sake, as well as others, that this can move forward. Anxiously awaiting your update. Martin ------------- Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11 |
Posted By: EileenF
Date Posted: May 22 2011 at 12:29pm
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my onc has prescribed metaforim for me outside of a clinical trial as my gulcouse levels are high due to the steroids ??? I take 500mgs 3x a day. my levels have come down with it ------------- 7/09:IDC,stg 3,Grade3, pos lymph;chemo ACT;12/09 lumpect n lymp disect;1/10 bilat masect/tis exp; rad cmpltd 4/10; 11/10 stg 4 lungs chest axil mets & parp trial;3/11 IBC diag; |
Posted By: 123Donna
Date Posted: May 22 2011 at 12:47pm
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Tracy, I'm looking forward to hearing what you find out. Eileen, I'm glad your onc prescribed it for you. Hope it helps with your levels. ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: KenR
Date Posted: May 22 2011 at 1:23pm
| My wife was on it, but the steroids drove her sugar so high, she had to go on insulin. Tomorrow is her last chemo (YEAAAAAAAA!!) and I am going to make an appointment with her endocrinologist and get her back on metformin. |
Posted By: LauraT
Date Posted: May 22 2011 at 2:34pm
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Here's a quote from the NYT article that I have a question about: "Even if blood sugar levels fuel tumor growth, however, experts say that trying to lower the body’s overall level of blood sugar — like by starving oneself — would probably not be effective. That is because, at least for people without diabetes, the body is very good at maintaining a certain blood glucose level despite fluctuations in diet. “When a patient with cancer is calorically restricted, the amount of glucose in the blood until they are almost dead is close to normal,” said Dr. Michael Pollak, professor of medicine and oncology at http://topics.nytimes.com/top/reference/timestopics/organizations/m/mcgill_university/index.html?inline=nyt-org - McGill University in Montreal. Also, Dr. Pollak said, tumors are adept at extracting glucose from the blood. So even if glucose is scarce, he said, “the last surviving cell in the body would be the tumor cell.” So efforts are focusing not on reducing the body’s overall glucose level but on interfering specifically with how tumors use glucose." Here's my question - So based on this, for those of us who aren't diabetic, trying to limit glucose intake (as recommended by so many in the alternative med field) isn't really going to affect cancer growth, but getting on something that changes the way cancer utilizes glucose (like metformin?) could prevent or stop cancer growth?
I do believe that limiting sugar intake is good for health on many fronts, but I don't want to falsely believe that doing this is anti-cancer if it really isn't. Make sense??
Laura
------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: TracyAMac
Date Posted: May 24 2011 at 10:24pm
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Today I went for my 6 month check up re the Metformin Trial. My regular onc. was not there today but his colleague said she read something just this past Friday about the path has just been cleared to get this trial going in the U.S.!!! I hope this is true and that things move quickly to the States. I couldn't wait at the hospital this morning to pick up my "barrel" size container of trial drugs for the next 6 months so I will be back to the hospital Thurs or Fri this week and will have a little more time to spend with the Trial Coordinator - if I get anything in writing about the status of the trial drugs being shipped to the U.S or any new info. I will let you know Crossing my fingers! Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: TracyAMac
Date Posted: May 27 2011 at 5:23pm
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Hi everyone Was back at the hospital today and was able to talk with the Metformin Clinical Trial Coordinator. She said there definitely was a recent announcement about the trial drug -now able to go to the U.S. She thinks it is posted on the NCIC web site. Sorry I haven't had a chance yet to go find it but wanted to get this update to you ASAP - esp. for those of you whose eligibility date for the trial is soon expiring. Here's hoping things move quickly!!! Please keep me informed of any futher problems in accessing this trial and I will apply more pressure at this end Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: TNinTN
Date Posted: May 27 2011 at 6:53pm
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Thanks, Tracy. Susan will be back for a follow-up with her surgical oncologist in two weeks and I will try to check on it from this end. We are not scheduled to see her medical oncologist until July (a week berfore she becomes ineligible), but I hope to at least be able to get an update in early June. Thanks again for helping with this. Martin ------------- Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11 |
Posted By: TracyAMac
Date Posted: May 27 2011 at 7:42pm
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Hi - may I suggest to anyone in the U.S. who is close to the end of the eligibility period for the Metformin trial to start making calls now if you or a loved one is considering participating. I think the requirement is one day from date of first core biopsy or surgery. There are many forms to be filled out as well as blood tests (some of the non-standard ones I recall took a while to get back), plus a physical assessment, chest x-ray etc -- all required to be done prior to starting the trail as outlined in the trial document requirements. I would be sad to see a TN friend miss this by only a few days or weeks. Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: TracyAMac
Date Posted: May 27 2011 at 8:03pm
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Opps...i meant to say that to be eligible for the Metformin Trial I think you have to be signed up within one year of first core biopsy or surgery...not one day! How long can I say `chemo brain still in effect!...
------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: 123Donna
Date Posted: May 27 2011 at 8:37pm
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Tracy,
Based on that requirement, I'd be disqualified. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: TracyAMac
Date Posted: May 27 2011 at 8:53pm
Oh Donna, I wish and hope that isn`t the case  I just did a quick scan of the trial description. It says `diagnosis and definite surgery treatment within past 12 months...at least 4 weeks since completion of definite surgery and or chemo... I can`t tell if people with mets can be included . There are so many criteria - probably best for anyone who might be interested to read it from top to bottom. http://clinicaltrials.gov/ct2/show/NCT01101438 Love Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: TracyAMac
Date Posted: May 27 2011 at 9:03pm
more from the Metformin Trial criteria:
Tracy in Toronto  ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: 123Donna
Date Posted: May 31 2011 at 10:05pm
Metformin to Treat Early-Stage Breast CancerName of the Trial Principal Investigators Why This Trial Is Important Although these treatments are effective in curing many patients with early-stage breast cancer, some patients will experience a http://www.cancer.gov/dictionary?CdrID=45866 - relapse , and some will ultimately succumb to their disease. Consequently, doctors are eager to find new treatments for early-stage breast cancer or ways to improve the effectiveness of existing treatments. The drug http://www.cancer.gov/dictionary?CdrID=631043 - metformin (Glucophage) has been used for decades to treat people with http://www.cancer.gov/dictionary?CdrID=44129 - diabetes . Researchers have found that diabetics taking metformin are less likely to http://www.ncbi.nlm.nih.gov/pubmed/19564453 - develop cancer or http://www.ncbi.nlm.nih.gov/pubmed/16443869 - die from the disease than diabetics who do not take metformin. In addition, women with early-stage breast cancer taking metformin for diabetes have http://www.ncbi.nlm.nih.gov/pubmed/19487376 - higher response rates to presurgical, or http://www.cancer.gov/dictionary?CdrID=45800 - neoadjuvant , therapies than diabetic patients not taking metformin or patients without diabetes. Recent results of studies in women with breast cancer who are waiting for surgery have shown that metformin may slow tumor cell growth. These observations have suggested that metformin may be helpful in preventing http://www.cancer.gov/dictionary?CdrID=45861 - recurrences in women treated for early-stage breast cancer. In this trial, nondiabetic women or men younger than age 75 who have been diagnosed with early-stage breast cancer within the previous 12 months and who have undergone surgery to remove their tumor will be randomly assigned to take metformin or http://www.cancer.gov/dictionary?CdrID=46688 - placebo pills twice a day for 5 years. Participants in the trial may also receive adjuvant hormone and/or radiation therapy, but any chemotherapy (adjuvant or neoadjuvant) must have been completed prior to joining the study. Doctors will monitor the study participants to see if metformin improves http://www.cancer.gov/dictionary?CdrID=44023 - disease-free survival , overall survival, and a number of other medical, biological, and quality-of-life http://www.cancer.gov/dictionary?CdrID=346519 - endpoints . “We think metformin may act against breast cancer through http://www.cancer.gov/dictionary?CdrID=46187 - insulin -mediated or insulin-independent mechanisms of action, or both,” said Dr. Goodwin. “First, it may lower insulin levels, thereby reducing signaling through the http://www.cancer.gov/dictionary?CdrID=530323 - PI3K [signaling] pathway, which is a growth/proliferation pathway in breast cancer cells. Secondly, independent of insulin, metformin alters metabolism in the http://www.cancer.gov/dictionary?CdrID=44060 - mitochondria and turns on the [enzyme] AMP kinase, which then inhibits http://www.cancer.gov/dictionary?CdrID=653126 - mTOR , a protein that helps regulate cell division and survival,” she explained. “So, metformin is biologically a very interesting drug, and because it’s been used so widely, its side effects are well known,” Dr. Goodwin added. “In general, it’s a very safe and well-tolerated drug if you avoid its use in patients older than 80 and those with abnormal liver, kidney, or cardiac functions. The most common side effects are mild bloating and diarrhea that usually go away on their own after a few months, but we are starting off at half the dose of metformin for the first 4 weeks to help participants adjust.” For More Information http://www.cancer.gov/ncicancerbulletin/053111/page6 - http://www.cancer.gov/ncicancerbulletin/053111/page6 ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: 123Donna
Date Posted: May 31 2011 at 10:08pm
Posted By: TracyAMac
Date Posted: Jun 01 2011 at 8:20am
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Thank you Donna for posting all of the Metformin trial info. We love you for everything you do! Tracy in Toronto ------------- TN&non-TN tumors April/10 Gr3&2;1 metaplastic Rmast.1/9 nodes w/isolated t.cells Taxotere&Cytoxan x6 Bone cancer 1980 age17;surgery&chemo AC+Methotrexate BRCA-ve On hormone therapy & Metformin Trial |
Posted By: 123Donna
Date Posted: Jun 01 2011 at 8:53am
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Tracy, I'm pretty sure I'm not eligible, especially reading the dx and surgically treated within the last 12 month part. However, I'm going to still ask my onc when I meet with her later this month. I posted another study on a different thread of how tumor cells not only use glucose to survive and grow but can also adapt and use fat cells when deprived of glucose. Gee, that's not what I wanted to hear. I just look at my thighs and know I have too many fat cells! Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: 123Donna
Date Posted: Jun 02 2011 at 7:38am
Diabetic Drug Could Help Prevent The Spread Of CancerA protein activated by certain drugs already approved for treating Type II http://www.medicalnewstoday.com/info/diabetes/ - diabetes may slow or stop the spread of breast tumors. "It's possible that these diabetes drugs could ultimately be used, alone or in combination with existing chemotherapeutic drugs, to treat some forms of http://www.medicalnewstoday.com/articles/37136.php - breast cancer ," says Chris Nicol, an assistant professor in the Department of Pathology and Molecular Medicine and Queen's University Cancer Research Institute. As a diabetes treatment, this class of drug activates a protein that helps to maintain normal fat and sugar metabolism. Recently this protein has also been found to decrease malignancy and metastatic spread of some forms of breast cancer tumors. In earlier research, Dr. Nicol found that removing or reducing this particular protein in specific cell types such as breast cells increased the likelihood of http://www.medicalnewstoday.com/info/cancer-oncology/ - cancer developing and the cancer was often more prone to malignancy and spreading. This finding suggests that women who have reduced activity of this protein in their breast or associated cells and who are exposed to risk factors such as environmental or chemical pollutants or a poor (high fat) diet are more likely to develop more tumors. Furthermore, these tumors are more likely to spread throughout the body. To read the entire article: http://www.medicalnewstoday.com/releases/227086.php - http://www.medicalnewstoday.com/releases/227086.php ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: mainsailset
Date Posted: Jun 02 2011 at 10:45am
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When I combine the information here on the metformin with the thread on the cancer cells' love of glucose and fatty acids it seems so reasonable that how our bodies process the foods must be called into question. If that process is compromised, which we see in metabolic syndrome (which is common place in patients with TN) then enhancing treatment by using metformin & checking thyroid & adrenals seems all the more imperative for our best outcomes.
------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: TNinTN
Date Posted: Jun 08 2011 at 7:33pm
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I spoke to our clinical trials nurse today and she said they thought this trial would finally be up in running in about two weeks. I sure hope there are no more delays. We go back the first week in July, a week before Susan becomes ineligible. Martin ------------- Wife age 53@dx TN IDC Stage IIA 7/10; BRCA1&2 Neg; BROCA Neg; LN Neg; taxol+cisplatin+/-RAD001x12(clinical trial); lumpectomy 12/10;ACx4; 33 Rads complete 4/11; NED 5/5/11 |
Posted By: 123Donna
Date Posted: Jun 08 2011 at 7:40pm
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Martin, Please keep us posted about this trial opening up in the U.S. It could be good news for so many women that want to participate in the trial. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Barbi
Date Posted: Jun 08 2011 at 10:15pm
| Keeping my fingers crossed for Susan to get into the trial! I will be right behind her! |
Posted By: tania
Date Posted: Jun 17 2011 at 12:41am
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Long time since I have been to the boards and I see alot of great info has been added here to my initial post!
As I started adjuvant chemo about a month ago I revisited this with my oncologist at Stanford. She noted the issues with the metformin trial drug availability and agreed to write an off label prescription. I was very pleasantly surprised! She won't let me start while on chemo but said I can start right after.
For those unable to qualify for the trial, I hope you might be able to find a doc that will prescribe and monitor.
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Posted By: 123Donna
Date Posted: Jun 17 2011 at 8:37am
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Tania, That is indeed good news for you. It may be better than participating in the trial. Isn't there a chance with the trial that you are placed in the placebo group and not getting the metformin? ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: mainsailset
Date Posted: Jun 17 2011 at 11:39am
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I'm a little confused as I thought one of the advantages of taking the metformin was to enhance the actual efficacy of chemo during treatments. ------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: tania
Date Posted: Jun 17 2011 at 12:55pm
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My understanding of the trial design is that it is a 50/50 chance of metformin vs. placebo, which is why I was interested in finding a doctor to prescribe.
Yes, some of the research I have read suggests that metformin can enhance the effects of chemotherapy, with the very notable exception that it possibly can interfere with the effects of platinum based drugs (which I beleive are proving to be among the most effect agents for TNBC, particularly BRCA-based disease, and is more commonly being dictated). I did a neoadjuvant trial with gem/carbo/parpi (phase II at Stanford for early stage disease) so I definitely didn't want metformin then, nor would my doctor consider it. I had asked about metformin now, with adjuvant 4X TC, but because none of this is proven out my doctor will prescribe metformin for me followng the guidelines of the trial -- after all treatment.
It felt like a big win for me to have her prescribe, so I didn't push the issue. Plus, I had a very good response on the trial so the adjuvant chemo for me is all about exposure to a tried and true, standard of care therapy.
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Posted By: 123Donna
Date Posted: Jun 27 2011 at 10:04am
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Tania, Do you know the dose of Metformin that you'll be getting? I'm also going to ask next month when I see my onc. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Rue Marbeau
Date Posted: Jun 27 2011 at 5:25pm
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Please also let me know the dosage. I have my next appointment for my taxol treatment on Thursday and want to ask my oncologist more questions about it, diane
Diagnosed with TN in 1/11. Has bilateral mastectomy. Stage 1. Grade 2 Size was was 2.1 centimeters. No lymph node or vascular involvement. Negative for BRCA 1 and 2. Did 4 dose dense AC and am now undergoing dose dense taxol (completed 2 out of 4). No radiation expected. Eanders to be exchanged in October. |
Posted By: tania
Date Posted: Jun 27 2011 at 6:06pm
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This is one of the questions I have for my doctor. Coincidentally my appt. is also on Thursday this week. I will report back with what she tells me. This is per the clinical trial guidelines for treatment:
Arm 1:
Metformin 850 mg PO QD x 4 weeks (ramp-up period) - means by mouth, once per day Metformin 850 mg PO BID for balance of 5 years - means by mouth, twice per day https://www.ctsu.org/public/data/protocols/NCIC%20CTG/NCIC-MA.32/pfs.pdf - https://www.ctsu.org/public/data/protocols/NCIC%20CTG/NCIC-MA.32/pfs.pdfthis is the link to the overview of the trial, with elegibility and all. ------------- DX 10/2010. 1.5cm, no nodes, grade 2. BRCA1+ Neoadjuvant chemo gem/carb/parpi trial. Bilateral mastectomy 4/2011 Adjuvant chemo 4X TC - 5/11 - 7/11 |
Posted By: mooneyswife
Date Posted: Jun 29 2011 at 11:43am
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Hi there, I was looking to see if anyone else was on this trial and found this post. I just started the trial yesterday (in Michigan) and would love to connect with anyone else on it. It is going to drive me crazy not knowing which arm I'm on. I'm still wondering if I should have pushed the doctor to prescribe Metformin "off label" rather than go through the trial.
------------- DX IDC TNBC 9/10 age 36, Stage IIIa, Grade 3, 3.9 cm, 4/17 nodes Lumpectomy 10/10 A/C x4 11/10 - COMPLETE, TX x12 - COMPLETE 33 Rads COMPLETED 5/31/11 Wife and momma of 2 girls - 5 & 7 |
Posted By: mainsailset
Date Posted: Jun 29 2011 at 3:01pm
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It's my understanding that the Trial, if you are in the Metformin arm, will be giving higher doseages of hte Metformin than if you were prescribed by a GP. ------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: 123Donna
Date Posted: Jun 29 2011 at 3:21pm
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Would a regular glucose test give you a clue if you're getting Metformin? If you knew your normal glucose level was say 80 and now it's significantly lower, then maybe it would be a clue that you are getting the actual drug. If it was the same level as you normally test, then maybe you're getting the placebo. Just a thought. . .
------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: mainsailset
Date Posted: Jun 29 2011 at 3:32pm
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Ha! Donna, you are one smart cookie! ------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: janet c.
Date Posted: Jun 29 2011 at 5:40pm
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I just want to warn anyone that is going on Metformin to beware of low blood sugars. I am actually a type 1 diabetic so I have had low blood sugars and they are not fun. You must make sure you eat on time and excercise also affects blood sugar. It is very serious and you need doctors to council you until you know what to do. Everyone just be careful and listen to your doctors. Medicines have side effects. Make sure you are under doctors care.
Janet ------------- dx 12/08 @47yrs.old TNBC stage 2a grade 3, 2.1cm. partial mastectomy sentinal node negative BRACA negative Cytocan/Taxatere x4 radiation 36 or 38rounds |
Posted By: LauraT
Date Posted: Jun 29 2011 at 7:10pm
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I asked my oncologist again about prescribing metformin for me and he won't do it. He said (as Janet has pointed out) it can have serious side effects and there is just not enough clinical evidence on how it affects non-diabetics. He was concerned about giving it to someone like me who has a low BMI and blood sugar levels that run on the lower end of normal. He prescribed it as an internist years ago and saw some bad side effects. Now of course, if this trial shows that it can be safely prescribed to non-diabetics, and it became an approved use, he would prescribe it. Bummer! I'm still going to ask Dr. Gonzales what she thinks. Laura Laura ------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: 123Donna
Date Posted: Jun 29 2011 at 8:59pm
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One nagging thought in the back of my mind: Is this another drug we're hoping will be the silver bullet? I remember when we heard the buzz a couple of years ago about the bisphosphonates (eg, Zometa) and how they might help prevent a recurrence. Then we saw disappointing study results. With TNBC, are we just willing to try anything?
------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: mainsailset
Date Posted: Jun 29 2011 at 10:42pm
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This is an article dating back to January '11, but indicating that the study is pointing towards metformin as a useful tool for TN's http://foodforbreastcancer.com/studies/6526 - http://foodforbreastcancer.com/studies/6526 ------------- dx 7/08 TN 14x6.5x5.5 cm tumor 3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear |
Posted By: 123Donna
Date Posted: Jun 29 2011 at 10:50pm
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Quote from the article: The authors conclude that, taken together, the findings suggest that the ability of metformin to suppress the oncogene, metastasis promoter and breast cancer stem cell marker CD24 may open a new avenue in the treatment of highly-metastatic subgroups of triple-negative (basal-like) breast cancers naturally enriched with CD44posCD24pos tumor-initiating cell populations. Is there a test for CD44pos, CD24pos? ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |