Chemo optional?
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Topic: Chemo optional?
Posted By: Cinderwee
Subject: Chemo optional?
Date Posted: Feb 07 2011 at 9:31pm
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My oncologist presented chemo as an option, due to the tumor size.
While I am going to proceed with the treatment, I thought being given
the choice was a bit odd....Has anyone else dealt with this? And, I'm worried that the regimen won't be potent enough. ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Replies:
Posted By: 123Donna
Date Posted: Feb 07 2011 at 10:04pm
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Cindy, From your signature it looks like your tumor was less than 2 cm. Is your oncologist only recommending Taxol? Most of us have had a combination of chemos, eg, T/C or A/C and T. Have you thought about getting a second opinion from another onc? Chemo is the only adjuvant therapy available for TNBC. We don't have any therapy like Tamoxifen for ER+ breast cancers. Here's a brochure you can download and read about TNBC. http://www.lbbc.org/Understanding-Breast-Cancer/Guides-to-Understanding-Breast-Cancer/Guide-to-Understanding-Triple-Negative-Breast-Cancer - http://www.lbbc.org/Understanding-Breast-Cancer/Guides-to-Understanding-Breast-Cancer/Guide-to-Understanding-Triple-Negative-Breast-Cancer Denise posted this important study in another thread: http://forum.tnbcfoundation.org/attentiOn-newbies-do-taxol-before-adriamycin_topic7771.html - http://forum.tnbcfoundation.org/attentiOn-newbies-do-taxol-before-adriamycin_topic7771.html Wishing you the best in your decision. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Cinderwee
Date Posted: Feb 07 2011 at 10:11pm
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I don't know the exact tumor size, only that the stereotactic needle biopsy removed most of it and lumpectomy removed MAYBE 1 millimeter (!) remaining. Yes, second opinion is exactly what I'm going to do, thank you. That's how the cancer was found after I was told the mammo revealed a common calcification and it was suggested I wait 6 months....thank God for second opinions!! And, thanks for reminding me it's an option and my right.
------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Cinderwee
Date Posted: Feb 07 2011 at 10:23pm
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Hmm...I stand corrected on the tumor size, from what I can tell from my path reports it was larger than I thought. Will have surgeon confirm tomorrow; but also they only did a sentinel node biopsy during surgery...I thought they were supposed to take out more and diagnose further after surgery. Not happy...I want some answers and plan on getting them first thing in the AM.
------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: 123Donna
Date Posted: Feb 07 2011 at 11:18pm
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Cindy, I think the size of your tumor will help you decide which treatment is best for you. It should be listed on your path report, but your surgeon can help you out also. The sentinel biopsy is the standard. If they find positive lymph nodes in the sentinel node(s), then they usually remove more lymph nodes (auxiliary). You are doing the right thing by educating yourself, asking questions and getting answers. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Cinderwee
Date Posted: Feb 08 2011 at 12:24am
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I should note that my ER was WEAKLY positive at 5% and have been told
that <10% is considered negative. Another factor in my concern too that the
recommended regimen will not be potent/accurate. Thanks....  ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Charlene
Date Posted: Feb 08 2011 at 7:53am
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Your case sounds very similar to mine, even the "common calcification" part. My oncologist said that the standard of care per NCCN guidelines for a triple negative tumor, greater than 1 cm, is adjuvant chemo therapy. I did 4 rounds of Taxotere/Cytoxan, 21 days apart. When I asked him why 4 instead of 6, he said that the survival rates were the same. All the investigating I have done since says that triple negative always requires chemotherapy. The best of luck to you!
Charlene ------------- DX 3/10 @59 ILC/TNBC Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads 3/14:NED |
Posted By: conniec
Date Posted: Feb 08 2011 at 8:57am
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Hi Cindy, My lumpectomy did not have clear margins at 1.3 cm. I had the sentinel node surgery before my double mastectomy b/c I wanted to rule out node involvement before reconstruction. I had the double mastectomy by choice and the final pathology was 1.7. I was told even at the 1.3 that I would get the 3 chemo drugs. The first onc I went to wanted to do the 2 week dose dense. Went for a 2nd opinion and found my current Onc. I've been on the every 3 week regime with Adriamycin, Cytoxan, and Taxotere. Technically, I was cancer free from the surgery.... the chemo is the triple punch at the microscopic cells that may be there. We each make our best choice given the info we have... make the right one for you. We are here to support you! Connie ------------- Age 40, Felt lump 8/20/10 Lumpectomy 9/7 DX 1.5 tumor stg I 9/13 margin not clear Double MX w/ expanders 10/8 Final tumor size 1.7, 0/3 + nodes AC-T chemo 11/8 - 2/21 TE/implant exchange 3/29 |
Posted By: Cinderwee
Date Posted: Feb 08 2011 at 7:58pm
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Spoke with my surg nurse, most of the tumor was removed during the stereotactic core biopsy, and <0.1cm during surgery, so best estimate of original tumor size is <1cm. Based on it having been triple neg and all the wonderful support and advice from all of you, I want the chemo. I just need to ensure the potency/accuracy of the recommended regimen, especially since the ER was weakly positive. I am doing that by getting a second opinion and will keep you posted.
As always - THANK YOU & GOD BLESS ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: trip2
Date Posted: Feb 09 2011 at 12:23pm
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Hello and welcome.
We would be interested in hearing what your second opinion turns out to be, best wishes. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: 123Donna
Date Posted: Feb 09 2011 at 2:38pm
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Cindy, I saw Steve post this under another thread and thought it may be useful information for you. (Steve, I hope you don't mind me doing this.) Prognostic Significance of Triple Negative Breast Cancer at Tumor Size 1 cm and SmallerEur J Surg Oncol. 2011 Jan 1;37(1):18-24, HW Lai, SJ Kuo, LS Chen, CW Chi, ST Chen, TW Chang, DR ChenTAKE-HOME MESSAGEBased on previous reports and this retrospective study from Taiwan, triple-negative tumor status is very likely an independent risk factor for small (<1 cm) node-negative invasive breast cancer. AbstractAims: The purpose of this study was to clarify the prognostic significance of triple-negative breast cancer (TNBC) with a tumor size ≤ 1 cm. Materials and Methods: Patients with primary operable breast cancer with a tumor size ≤ 1 cm were enrolled at Changhua Christian Hospital and National Cheng-Kung University Hospital. Tumors negative for ER, PR, and HER-2 were classified as TNBCs and compared with tumors with any receptor positivity (non-TNBC) for disease-free survival (DFS) and cancer-specific survival (CSS). Results: From 1995 to 2006, a total of 377 patients with tumor size ≤ 1 cm were enrolled. Compared with non-TNBC patients, TNBC patients with a tumor size ≤ 1 cm as a whole or in a lymph node-positive subgroup were not associated with a poorer 5-year DFS and CSS. In lymph node-negative patients (pT1a-bN0M0), TNBC was associated with a poorer 5-year CSS but not DFS. Compared with the hormone receptor-positive, HER-2-negative subgroup, TNBC was associated with poorer DFS and CSS. In the multivariate Cox regression hazard analysis, lymph node invasion was the most important cause of disease recurrence and cancer-specific death. Conclusion: TNBC is very likely an independent risk factor in small (≤1 cm) node-negative invasive breast cancer. With tumors 1 cm and smaller, lymph node invasion was the single most important prognostic factor. ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: SagePatientAdvocates
Date Posted: Feb 09 2011 at 3:08pm
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Dear Donna, I hope you are aware that everytime you do this under para 14.3, subchapter XXI of the addendum of the rules of message board engagement you owe me a hug, when we meet, so proceed at your own risk.. seriously, you are always free to transport my words...studies...I appreciate everything you do and your dedication to our TNBC family even in the midst of treatment is remarkable. You are truly an extraordinary woman.. your presence graces our board. all the best, Steve ------------- I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates |
Posted By: 123Donna
Date Posted: Feb 09 2011 at 3:14pm
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Steve, Thanks for the laugh, it made my day. I know sometimes I feel like I'm going to get a ticket or something. However, I feel like valuable information is important in sharing, even if we do get in trouble. I'm living dangerously anyway, so what's the harm in feeling a little rebellious? Take care dear friend, Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Cinderwee
Date Posted: Feb 13 2011 at 3:21pm
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I am starting to get apprehensive about the unknown (and some of the
known) effects of chemo...yes I have the percentages of
with/without....but isn't chemo going to ravage my body? Destroy my
ovaries? Oh God why can't there be a guarantee that if I put myself
through this that this monster can't come back? I'm willing to/in the
process of changing diet, exercise, etc.... I'm strong...what if I
can't handle chemo and stop? I'm trying not to come from fear; I think
these are valid questions, really for my onco but he's going to give me a
MEDICAL opinion and yes I need to hear the second opinion (this week)...thanks.... Thanks and GOD BLESS ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: 123Donna
Date Posted: Feb 13 2011 at 4:13pm
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Cindy, Here's a link to some of the side effects for Taxol. Not everyone will experience them. You'll find some people going through treatment have some or no side effects, while others do. Everyone's journey is different. Weekly treatment may have reduced side effects than tx every 3 weeks. http://www.breastcancer.org/treatment/druglist/taxol.jsp - http://www.breastcancer.org/treatment/druglist/taxol.jsp Hope you get your answers during your second opinion this week. Please keep us posted. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Cinderwee
Date Posted: Feb 17 2011 at 10:53pm
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Well...2nd onco wants an Onco DX on original biopsy. I believe the test was designed for ER+/PR+/Her2+, but since my ER was weakly positive at 5%, he still wants to do it. I will not let that alone change/make my decision but it will be interesting to see the results. I can have all the numbers there are, but at the end of the day I just need to be at peace with it and the rest is up to God.... ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Cinderwee
Date Posted: Feb 23 2011 at 9:11pm
Onco DX results should be in next week. In the meantime I've spoken with the pathologist (who conferred with 2nd opinion med onco and works at facility where initial biopsy path report created) and agrees that the Onco DX is a great idea to ensure accurate chemo regimen (IF? necessary). The path also says I am not 3NEG because my ER was weakly + at 5%, and am considered non-basal, luminal b and he's willing to speak with initial med onco. At this point I am just going to wait for the Onco DX results....needless to say I am FRUSTRATED. All I want is a clean, accurate, all inclusive path report so that accurate chemo (if needed) can be determined and I can move forward.  In God's hands,
------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: zoomommy2
Date Posted: Feb 23 2011 at 10:22pm
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Cindy,
Sorry you still don't have the answers you want/need yet. I'm not sure what % is considered still negative, but weakly positive. You definitely need to be able to move forward.
Lee in Denver ------------- dx6/09,stageII,gr3,(L)mastectomy 7/09,ACx4,Taxolx7,Avastin study,gall bladder surgery 1/10,4/11 Stage 4, mets to lung, 4/11 Started Taxotere and Xeloda, 5/11 Taxotere stopped, off Xeloda |
Posted By: Cinderwee
Date Posted: Mar 07 2011 at 11:28pm
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Thank you. Well, the latest news is that due to there being <2mm of invasive tissue available, an Onco DX test cannot be performed. And, I mis-spoke earlier; the initial pathology report states "ER weakly positive at 5%' with which the 2nd pathologist concurs, according to "CAP guidelines". The radio oncologist and initial med oncologist reports state the ER as negative as it is <10%. So the 2nd med oncologist who has already conferred with both pathologists, is going to discuss with initial med oncologist who recommended TX 1x weekly, x12 weeks. Ultimately, the decision is mine. I let go for the time being; let's hear what is said at the end of this week. Meanwhile, my 3 month window is closing....faith, attitude and taking care of self will see me through regardless. ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Cinderwee
Date Posted: Mar 14 2011 at 2:52pm
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Chemo to commence St. Patrick's day.
My med onco assures me HE (I insisted on only him, sorry no pass off to NP) will monitor me closely and if I so desire, I can have AC after and that the sequence does not matter; that in fact at MD Anderson (where he did his internship and my understanding one of the best facilities in the country) they administer TX first.
I can do this, in part because of all the awesome info and support here.
Many thanks
 Cindy ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: zoomommy2
Date Posted: Mar 14 2011 at 3:44pm
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Cindy,
You can do this absolutely! Taxol should be easier on you. It is for most people, but no guarantees.
Lee in Denver ------------- dx6/09,stageII,gr3,(L)mastectomy 7/09,ACx4,Taxolx7,Avastin study,gall bladder surgery 1/10,4/11 Stage 4, mets to lung, 4/11 Started Taxotere and Xeloda, 5/11 Taxotere stopped, off Xeloda |
Posted By: Cinderwee
Date Posted: Mar 14 2011 at 4:21pm
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Thank you, I must admit I am VERY apprehensive. I keep telling myself "just breathe"..... ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: LauraT
Date Posted: Mar 14 2011 at 5:27pm
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Cindy - Lee is right! You CAN do this and we'll be here every step of the way.
Love,
Laura ------------- DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva |
Posted By: zoomommy2
Date Posted: Mar 14 2011 at 5:34pm
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Cindy,
Virtually everyone finds the anticipation of starting chemo is far worse than the actual experience. Hoping that's what you will find, too.
Lee in Denver ------------- dx6/09,stageII,gr3,(L)mastectomy 7/09,ACx4,Taxolx7,Avastin study,gall bladder surgery 1/10,4/11 Stage 4, mets to lung, 4/11 Started Taxotere and Xeloda, 5/11 Taxotere stopped, off Xeloda |
Posted By: trip2
Date Posted: Mar 15 2011 at 8:01pm
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Yes once you begin it will become a sort of routine.
I found packing up a chemo bag helpful. That way you have things to fiddle with while getting your infusion. Books, newspaper, laptop, Ipod, phone, paper/pen, lap blanket, water, snacks, whatever you might want to have with you. The meds they give you can sometimes make you sleepy so the blanket feels good, comforting, having someone come with you, run out to bring lunch back or just a big cold drink with ice, whatever sounds good.
Check out our chemo tips in the tnbc news/resource section and best wishes for a smooth journey.
Be sure and ask questions and call the office if you have any concerns after treatment is given. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: Cinderwee
Date Posted: Mar 16 2011 at 1:17am
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Alrighty...seems the addendum re: her2neu to the initial path report did
not make it to initial med onco; I provided it to 3rd opinion med onco who I met with today (2nd one backed out after onco dx could not pe performed) 3rd found info re:her2neu reading that completely changes chemo approach
and regimen. Needless to say, I WILL NOT start chemo St. Patrick's day,
but I know I will soon once everything reports, slides, etc. have been
gone over again. I'm going underground again... will post details later....I'm done for now. Thanks for all the support. Peace, ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: 123Donna
Date Posted: Mar 16 2011 at 6:38am
Cindy, Are they saying the Her2 reading was changed on your path report? Is it now Her2 positive and making a difference with your treatment? Hope you get your answers soon. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Cinderwee wrote:Posted By: SagePatientAdvocates
Date Posted: Mar 16 2011 at 6:57am
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Dear Cinderwee, thank you for sharing with us.. it sounds like, reading between the lines (always dangerous to do), that, as Donna suggests, your HER2/neu was positive? If so HERCEPTIN may become an option for you? Your experience again points out the importance of a second pathology opinion...especially if FISH technology was not used the first time. Several months ago, a woman I know, had her pathology re-done and she, too, found out that she is not TN and a new treatment plan was commenced. good luck with your new treatment plan!!! and please try to find the beauty in each day. all the best, Steve ------------- I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates |
Posted By: mjhoover@gmail.com
Date Posted: Mar 16 2011 at 12:20pm
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Cindy, I agree with everyone here about second opinions and third and fourth ones too if needed. Glad you are thorough and getting good clarity on the markers (ER PR HER2). It does change things for sure! My first treatments were Taxetere, adriamycin, cytoxin. It was hard on my body (my body just doesn't like all these chemicals!!), but I did it one treatment at a time and I was sure I gave myself 'permission' to call the nurse anytime I had a question even if it seemed 'dumb' to me! These drugs can cause side effects you might not expect but a good onc and onc nurse can prescribe many things for side effects. The goal is to get through it if you can! I just kept asking questions until I was ok with the answers given. Take care and good luck to you...we are here for you on the boards too!! MJ
------------- 7/08 IDC L Br, mast 1/16 node +,St 2 gr 3, 6 rounds TAC 7/10 Mets to lungs, nodes abdomen BRCA- 8/10-1-11Abraxane/Avastin 7 11 3.3 cm tobrain sstem/rt cerribellium WBR 15 rds Poss trial at MDA after |
Posted By: Cinderwee
Date Posted: Mar 16 2011 at 4:30pm
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Core biopsy 11/19/10, initial path report 11/23/10, HER2 addendum 12/18/10 The HER2 FISH Analysis reads (in part): Results: 1.3 negative Comment: HER2 Genetic Heterogeneity (GH) is present. See Below. <1.80=Negative 1.80-2.20=Equivocal >2.20=Positive Karyotype: nuc ish 17 cen(D17Z1x 2-4), 17q11.2-12 (HER-2x 2-6) [40] *HER2 FISH Results: Number of Tumor Cells Counted: 20+20 Number of Observers:2 Average Her2 Signals/Nucleus: 3.7 Average Number of CEP 17 Signals/Nucleus: 2.9 Ratio Average: HER2/CEP 17: 1.3 THIS WAS THE CLINCHER: Results of GH Region 7.5% of invasive tumor demonstrates HER2 amplification. Amplified cells are scattered. Suggested regimens: 1) Taxotere and Cytoxan + Herceptin every 3 weeks x 4 doses, include 3 days of Decadron Neulasta shot day after infusion Then Herceptin every 3 weeks x 1 year. 2) Taxol 1x week x 12 weeks Cytoxan every 3 weeks x 4 doses Decadron day of Herceptin include with either above and continue every 3 weeks for 1 year Option 1 is favored by the 3rd med onco as it is most widely used; Option 2 seems "less scary" to me. The facility he is at (AZ Cancer Center in Tucson) is also going to have a BREAST path review core biopsy slides for hormone growth dependency for potential follow up hormone therapy, this should not hold up my starting chemo. I had the FULL path report faxed to my init med onco, discussed over the phone and meet with him tomorrow. Thanks for listening....will definitely keep you posted and would appreciate all feedback on either suggested regimens above. AND - Thanks for all the wisdom and support; I am truly grateful. ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Cinderwee
Date Posted: Mar 20 2011 at 2:30am
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the Her2 is being retested further
due to the amplification of some cells. The intent is to determine if I
will need aromatose inhibitors long term. It has been determined
with finality that I am 3NEG; just that the ER is weakly positive at 5%,
and there are some scattered Her2 amplified cells....sigh...I'm going
for treatment option 2. I don't like the sound of option 1 due to
triple decadron, nor my body being slammed, then attempting to heal,
then slammed again, especially since it slams so hard it has the
potential to mess with my bone marrow causing the need for Neulasta
shots....unless the second path report reveals some other anamoly, chemo
to commence 3/24. Wish me luck, and as always - THANK YOU!
------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: 123Donna
Date Posted: Mar 20 2011 at 10:18am
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Cindy, Good luck with your treatment. I know it's so hard to decide when you get different opinions and anomalies with your tumor type. Keep us posted. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: zoomommy2
Date Posted: Mar 20 2011 at 12:29pm
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Cindy,
The treatment options sound very similar except for the days of Decadron. I had 3 days of Decadron with my A/C and didn't have a problem with it. It was supposed to be for the possible nausea. I never had any nausea. Sounds like you definitely need the Herceptin. The Cytoxan will zap your white cells, but the Taxol/Taxotere shouldn't be so hard on you. If you get Cytoxan every 3 weeks, your white count may well recover by the time of the next treatment. Either decision sounds reasonable. If it's your choice, go with what seems best for you. We never know if we are making the best choice. It's just the best decision we can come up with for us. Good luck and keep us informed as to how you are doing.
Lee in Denver ------------- dx6/09,stageII,gr3,(L)mastectomy 7/09,ACx4,Taxolx7,Avastin study,gall bladder surgery 1/10,4/11 Stage 4, mets to lung, 4/11 Started Taxotere and Xeloda, 5/11 Taxotere stopped, off Xeloda |
Posted By: bondande
Date Posted: Mar 21 2011 at 12:06pm
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I also had the three days of decadron with the a/c. I am sure it helped with the nausousness but I hated the depressed crash when I finished it. good luck to you all, Bonnie
------------- age55,Stg2a,Gr3,3.8cm tumor,mod.rad.mast.lft brst3/4/09,4ac,4taxol,33 rads.done11/2/09.BRCA1+oophorectomy1/5/2010,mast.rt brst 2/18/10,NED,bonescan 8/16/10,NED,catscan11/29/10NED catscan 3/17/11 NED |
Posted By: Cinderwee
Date Posted: Mar 21 2011 at 9:09pm
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I just want to say "THANK YOU" to everyone for your support and wisdom. Much love, ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: trip2
Date Posted: Mar 22 2011 at 1:17pm
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Best wishes and hoping for a smooth journey, please let us know how you are doing. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: janet c.
Date Posted: Mar 22 2011 at 7:55pm
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Cinderwee,
The Decadron is actually a steroid given just in case you happen to be allergic to the chemo. Either Emend, Zofran or copazine are for nausea. I had the neulasta shots and after the first shot two days after I had terrible bone pain and when I went for my next shot my oncologist nurse told me to pre-medicate with Tylenol. I went home and took extra strength Tylenol every 6hrs. for two days and I never had another bone pain again. I did this for each neulasta shot and I actually started the Tylenol right before I got the shot and then every 6hrs. I didn't get the Emend anti-nausea pill but I had the Zofran and the Compazine and I started to pre-medicate with those after my chemo and I didn't get nauseous. I wish you the best of luck and hopefully you will do fine. ------------- dx 12/08 @47yrs.old TNBC stage 2a grade 3, 2.1cm. partial mastectomy sentinal node negative BRACA negative Cytocan/Taxatere x4 radiation 36 or 38rounds |
Posted By: Cinderwee
Date Posted: Mar 25 2011 at 8:00pm
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Yesterday was my 1st (option 2) infusion, tired today, not much appetite...but grateful to have finally gotten started. Chemo nurse says I did well and can hopefully cut both the Benadryl & Decadron; and have also decided it would be wise to get a port. So wow, I'm 3NEG yet ER weakly positive @ 5% and SOME Her2 amplification....I now know for certain....NOTHING is black & white...
Chopped my hair last Saturday and actually like it better than before, so liberating too!
As always - thank you & God Bless  ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: unklez
Date Posted: Mar 26 2011 at 1:56am
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Dear Cindy, As Janet indicated, Decadron is a steroid intended to reduce chances of allergic reactions to (the solvent used for) Taxol. FYI some oncs use a larger dose of Benadryl instead of Decadron. Hope this helps. ------------- Wife Dx: Jul/09. Age: 37. Size: 3cm. BRCA: -ve. Lumpectomy: Aug/09. Micromet 1/9 node. Chemo Start: Sep/09. E5103. DD ACB-> DD Abraxane (Taxol reaction). Zometa (S0307). Canadian Fraction Rads. |
Posted By: Barbi
Date Posted: Mar 26 2011 at 8:41am
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Also, Benadryl gives me restless legs so we switched to claritin after a week and it was sooo much better. Also decreased the decadron after a couple weeks as I hadn't had any reaction. Made life a little easier afterwards. Barbi
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Posted By: 123Donna
Date Posted: Mar 26 2011 at 9:31am
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Cinderwee, The first time I only had 4 tx and didn't get a port. It still did a number on the veins in my hand. This time with many tx needed, I got a port and it's been wonderful. I don't like the alien look on my chest where it protrudes but it sure has made infusions very simple and painless. ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: Cinderwee
Date Posted: Apr 01 2011 at 12:03am
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I had a power port put in yesterday, too sore to use for the 2nd infusion (today) but look forward to using it going forward (at least 1 year). Today was my 2nd infusion took 4 hours instead of 6 and they did cut both the Benadryl & Decadron in HALF! Yaay!! 2 (chemo) down, 10-14 (still debating Cytoxan) to go......
Peace & love, ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: trip2
Date Posted: Apr 01 2011 at 11:53pm
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Thinking of you Cindy. ------------- Stage 2 2003 Stage 1 2007 BRCA 1+ |
Posted By: Cinderwee
Date Posted: Apr 02 2011 at 1:15am
Thank you  ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: SagePatientAdvocates
Date Posted: Apr 02 2011 at 1:19am
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Hang tough, Cindy..you can do this... and please try to find the beauty in each day... all the best, Steve ------------- I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates |
Posted By: 123Donna
Date Posted: Apr 02 2011 at 11:07am
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Cindy, Thinking of you. Stay strong, you'll get through this. When I had my port put in I was sore for a few days, but it went away. I didn't want it the first time around with only 4 treatments, but this time it's been a godsend. It makes the infusions so much simpler than trying to go into the veins. Wishing the best to you. Donna ------------- DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
Posted By: sue
Date Posted: Apr 02 2011 at 11:23am
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Hi Cindy, Sending peaceful thoughts your way. You will get through okay. One thing I did was listen to soothing music on my Ipod for comfort and serenity. I picked the quiet-sounding tunes like Moon River by Audrey Hepburn. Whatever makes you feel better is good though. Here for you if you have any questions or need to talk. Sue ------------- Dx 7/10, age 53. TNBC left breast, stage I, grade 3, IDC 0.5 cm, DCI 2.5 cm, 0/8 lymph nodes neg. BRCA-. T/C x4 finished 2/09/11, rads x34 finished 4/21/11. |
Posted By: Cinderwee
Date Posted: Apr 07 2011 at 6:44pm
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Power port used for the first time today (3rd infusion) , what a convenience!! And I can never emphasize enough how much I appreciate all your wisdom and support....sometimes I wish we all lived in the same vicinity so we could have a face to face support group, but I am VERY grateful to have this one. MUCH gratitude and respect to you ALL  ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Cinderwee
Date Posted: Apr 08 2011 at 4:26pm
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Well...the inevitable occurred this morning....hair is going....I'm viewing it as part of my metamorphosis. And, it does prove the Taxol is working (killing the good as well as the bad) so...Other than this, I feel so much better than expected. I am grateful.
Peace, ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: Martha
Date Posted: Apr 08 2011 at 6:52pm
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Cindy, I had very little side effects with the TAC chemo. My pre-meds and post chemo meds included decadron and emend. They kept me free from nausea. I got a pretty good buzz from the decadron, so had a high energy level too. Losing my hair was my hardest side effect to deal with. I had a few days of "metal taste".....but using plastic utensils helped with that.....starbursts also helped when it got really bad. I wish you the best of luck with this regimen. I hope it works for you.....and you are NED (no evidence of disease) when you're done. Take care. Warm Hugs From Texas, Martha ------------- Dx 10/08;mastect 11/08; T2/N1/M0;TACX6;rads 5-6/09; recur 11/09;recur 3/10; xeloda + Ixempx5;recur 1/11; gem + carbo + iniparib 2/11; BRCA1/2 -; dx prog 1/12; Havalen Mar Apr 12;Abraxane, May-present. |
Posted By: Cinderwee
Date Posted: Apr 10 2011 at 9:16pm
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I may be able to avoid the total buzz for a couple more days....what I am noticing are red, welt type bumps on my head and a couple on my face and back. They are not pimples, but they hurt. Has anyone else experienced this? ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |
Posted By: mjhoover@gmail.com
Date Posted: Apr 10 2011 at 9:23pm
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when i was on abraxane and avastin i had bumps on my head and face. i showed it to my onc who prescribed a roll on type antibiotic. during the time i got tx i used the drug and ithelped clear up the bumps. good lucka mj ------------- 7/08 IDC L Br, mast 1/16 node +,St 2 gr 3, 6 rounds TAC 7/10 Mets to lungs, nodes abdomen BRCA- 8/10-1-11Abraxane/Avastin 7 11 3.3 cm tobrain sstem/rt cerribellium WBR 15 rds Poss trial at MDA after |
Posted By: Cinderwee
Date Posted: Apr 10 2011 at 9:25pm
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Thank you ------------- Cindy 46 DX 11/29/10 Stg1 G3 IDC ER-PR-Her2- <1cm,cln marg,0/1 neg No BRCA Lumpectomy 12/28/10 MammoSite rads 1/10-1/14 Taxol/Her x12 DONE! CVP/Her ev 3wks x4 begin 6/23 Continue Her Mar2012 |