Zometa for TN's?
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Topic: Zometa for TN's?
Posted By: LisaMarieS
Subject: Zometa for TN's?
Date Posted: Apr 30 2010 at 12:32am
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i am wondering if anyone has had zometa following chemo and rads?
i know the trial has shown reduction in mets across the board, brain bone & liver etc... with this treatment. but the trial was on ER+
does anyone have info on Tn's with zometa?
my onc rec's it because of raised alk phos, in her words "couldn't hurt, only help".
i tend to agree based on prelim information.
any info or links would be greatly appreciated.
Lisa
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11/05 misdx needle biopsy
9/06 dx 37yrs old
10/06 lump/axil diss-TNBC
Infil Carc w/medullary features 3.1cm, 13 neg nodes, stage IIa, grade 3
11/06-3/07 6x TAC
6/07-8/07 rad's
7/07-BRCA 1/2 Neg
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Replies:
Posted By: 123Donna
Date Posted: Apr 30 2010 at 12:41am
Hi Lisa,
There's been some discussion about Zometa and Bisphosphonates in general. Here's a link to a thread on the topic:
http://forum.tnbcfoundation.org/bisphosphonates-clinical-trial-any-info_topic4591.html?KW=bisphosphonates - http://forum.tnbcfoundation.org/bisphosphonates-clinical-trial-any-info_topic4591.html?KW=bisphosphonates
http://forum.tnbcfoundation.org/zometa_topic5134_page1.html - http://forum.tnbcfoundation.org/zometa_topic5134_page1.html
http://forum.tnbcfoundation.org/bisphosphonates-clinical-trial_topic5110_page1.html?KW=bisphosphonates - http://forum.tnbcfoundation.org/bisphosphonates-clinical-trial_topic5110_page1.html?KW=bisphosphonates
I'm in a clinical trial but was assigned to the Clodronate arm.
Donna
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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Posted By: LisaMarieS
Date Posted: Apr 30 2010 at 12:59am
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my original onc wanted me in a trial for biophosphonates so i am inclined to believe it is the right move for me. ---
i thank you for the links.
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11/05 misdx needle biopsy
9/06 dx 37yrs old
10/06 lump/axil diss-TNBC
Infil Carc w/medullary features 3.1cm, 13 neg nodes, stage IIa, grade 3
11/06-3/07 6x TAC
6/07-8/07 rad's
7/07-BRCA 1/2 Neg
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Posted By: dmwolf
Date Posted: Apr 30 2010 at 9:16am
Lisa, it's not true that 'it can't hurt'. Bisphosphonates are powerful drugs that carry risks, among them ONJ (osteonecrosis of the jaw) and weakening of the bone. Read up on the links Donna gave you so that you can make an informed choice. Also, the studies of clodronate (same drug class) from europe that followed women for 10 years found that bisphosphonates delay met disease but do not really prevent it, as at 10 years out the control and treated arms converged. I guess what I'm trying to say is that given that you are now over 3 years out from your diagnosis, and therefore now at much lower risk for ever having a recurrence, you'll want to think harder about risks vs benefits. The calculus is different for a woman in your position than it is for someone still in the 'window' of highest risk of recurrence. Still, I agree that if you do something like a single zometa infusion per year for maybe two years, THAT shouldn't hurt (though there are no guarantees) and might help. To go for the intensive monthly or even every two months infusion schedule would I think be a mistake given your current low risk status and the higher risk of unwanted side effects from Zometa if you have a lot of it. ONJ is a nightmare, and there have been reports of femurs breaking from the drug, also horrible.
Good luck deciding,
Denise
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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Posted By: 123Donna
Date Posted: Apr 30 2010 at 10:42am
Lisa,
Like Denise said it's good to read up and make an informed decision with your dr. There's been a lot of discussion about this on breastcancer.org also. Here's a link to that topic:
http://community.breastcancer.org/forum/6/topic/729712 - http://community.breastcancer.org/forum/6/topic/729712
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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