Hormone Replacement
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Category: TNBC Forums
Forum Name: TNBC Polls & Surveys
Forum Description: A place to ask questions and survey the community
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=6121
Printed Date: Mar 26 2026 at 8:23pm
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Topic: Hormone Replacement
Posted By: sarahbeard1
Subject: Hormone Replacement
Date Posted: Apr 14 2010 at 4:58pm
I had my ovaries removed because of BRCA+, but I am only 33, and I am worried about osteoporosis. I am nervous about taking hormone replacement though, even though my oncologist gave me the go-ahead (he didn't seem too sure about his answer though). Has anyone taken hormone replacement after tnbc? Does anyone know if it increases the risk of recurrence for our type of cancer? And what about alternatives to hormones? Is there anything else that will prevent osteoporosis?
Thanks!
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DX 7/2009 tnbc, IIb, BRCA1+, 4 dd AC, 2 dd taxol, 2 abraxane, bilateral mastectomy, 25 radiation, reconstruction, ovaries removed (brca1), hysterectomy. Age 32 at DX.
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Replies:
Posted By: 123Donna
Date Posted: Apr 14 2010 at 8:46pm
Sarah,
I'm no expert and can only share with you what my ob/gyn said to me. Even though I'm tnbc, he felt uncomfortable prescribing any type of hormone replacement therapy. That was his opinion and other doctors may not see a risk.
If you're worried about osteoporosis, can you ask about a bisphosphonate drug, like Zometa or Boniva?
Donna
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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Posted By: kirby
Date Posted: Apr 15 2010 at 1:40am
Do you have a family history of osteoporosis? You have brought up a good point. I was somewhat concerned being thrown into chemopause being 12 years older than you.What about excersizing and weight training ? I have done both for years and did have a scan for bone density for a baseline a while after finishing chemo. I did just fracture my wrist [ falling in an excersize class LOL] and the recovery after getting the cast off has not been fun. I will revisit the whole bone density subject with my dr. next visit. You are wise to think of this. Although I am not sure HRT is the way to go and my onc also advised to never take it.
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kirby
dx Feb. 2001. Age 44
Lumpectomy
2cm. no nodes stage 1 grade 3
4 rnds AC, 35 rads
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Posted By: sarahbeard1
Date Posted: Apr 15 2010 at 2:22pm
Thanks for your input, ladies. I was searching on line and I found some helpful information (see below). I've decided to definitely not do HRT.
http://hormonenegative.blogspot.com/2009/08/is-hrt-safe-after-triple-negative.html
Friday, August 14, 2009
http://hormonenegative.blogspot.com/2009/08/is-hrt-safe-after-triple-negative.html - Is
HRT safe after a triple-negative breast cancer diagnosis?
I got a question from a reader about taking hormone replacement therapy
after a triple-negative breast cancer diagnosis—she is five years
post-diagnosis disease free. (Yea for her.) I cannot find any research
on this specific issue, but I did find a few related studies. Some of
you might have similar questions, so I am posting this for others who
might be in this situation.
• Some cases of HR- recur as HR+.
Research on this was published in the http://www.blogger.com/%28http://annonc.oxfordjournals.org/cgi/content/full/mdp028v1%29 - Annals
of Oncology . It was a
pretty small sample, though—only 40 women initially.
• Estrogen can be a
factor in the earliest formation of hormone-negative disease, according
to research in the http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8X-4M4CMY5-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=980888237&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=be3bba09fa5f3b979e190d63860b4047 - Journal
of Steroid Biochemistry and Molecular Biology.
• The
association between HRT use and breast cancer was the same for TNBC as
for other forms of breast cancer in another study in the http://annonc.oxfordjournals.org/cgi/content/full/18/11/1904 -
Annals of Oncology.
• Oral contraceptives were associated
with a higher risk of TNBC in a study published in the journal http://cebp.aacrjournals.org/cgi/content/abstract/18/4/1157 - Cancer
Epidemiology, Biomarkers and Prevention .
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DX 7/2009 tnbc, IIb, BRCA1+, 4 dd AC, 2 dd taxol, 2 abraxane, bilateral mastectomy, 25 radiation, reconstruction, ovaries removed (brca1), hysterectomy. Age 32 at DX.
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