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Mammaprint

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Forum Name: Archived Topics
Forum Description: Archived Topics
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=6019
Printed Date: Jul 10 2020 at 11:56pm
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Topic: Mammaprint
Posted By: Mary58
Subject: Mammaprint
Date Posted: Mar 30 2010 at 4:03pm
What does anyone think about this new test they call a Mammaprint?  Does that apply to us TN people?     Mary



Replies:
Posted By: TNBC_in_NS
Date Posted: Mar 30 2010 at 9:28pm
I found this link.  Not sure if it will help TN or not but they seem to think that this testing will be able to tell if and when recurrence will happen. 
http://www.medgadget.com/archives/2007/02/mammaprint_a_br.html - http://www.medgadget.com/archives/2007/02/mammaprint_a_br.html


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Diag@57TNBC04/092.5cm Lquad 05/09 TCx4Radsx30CT03/01/10 FU03/31/10ClearBRCA- 01/2011 RTNBC BMX 06/14/2011~2013 clear


Posted By: 123Donna
Date Posted: Mar 30 2010 at 9:44pm
Mary or Helen,

Is the Mammaprint an available test today?  I've never heard of it nor was I ever offered it.  Interesting. . .


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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15



Posted By: Guests
Date Posted: Mar 30 2010 at 10:08pm
It has become the European standard, probably not so useful for TNs as most or all ER-negatives are assigned in the high risk category.  The test looks at a gene expression profile and categorizes tumors into high, intermediate, or low risk of recurrence.  There's also a calculation of anticipated benefit from chemo for the high risk people.   It's a great test in that it saves a lot of women from going through chemo unnecessarily.   The woman who developed the test and saw it through the approval process in Europe is coming to UCSF in a permanent position.  She is just wonderful, professionally and as a human being.  Just stellar.  Expect more from her!

-Denise


Posted By: 123Donna
Date Posted: Mar 30 2010 at 10:38pm
Denise,

Thanks.  How come you're a "guest"?


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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15



Posted By: caro36
Date Posted: Mar 31 2010 at 4:44pm
I talked about the Mammaprint test at the hospital where the test was developped. They told me that TN Mammaprint test outcome tested 96% as aggressive. Since the test wasn't in the insurance plan last year I decided to skip the test and save EUR 2.675,--. The Mammaprint is a very promissing test but it's not the european standard. As far as I know in the Netherlands (where the test was developed) it's still not covered by the insurance policies and therefor not part of the standard care.

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lumpectomy 9/2/08 6mm TN tumor
38 rads, 13 boost
6xTAC finished 04/10. BRCA1+ bill. mastectomy, imm. reconstruction using tissue exp 01/10


Posted By: Mary58
Date Posted: Mar 31 2010 at 6:24pm
Hi - My tumor was 5 mm, and I wasn't offered chemo.  It was not recommended.  I am curious about why they offerred it to you.  I am going for a second opinion on Friday.  But.......  Thanks.  Mary


Posted By: caro36
Date Posted: Apr 01 2010 at 10:46am
send you a PM Mary

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lumpectomy 9/2/08 6mm TN tumor
38 rads, 13 boost
6xTAC finished 04/10. BRCA1+ bill. mastectomy, imm. reconstruction using tissue exp 01/10


Posted By: Janrr6
Date Posted: Aug 06 2010 at 8:57am
Hi Everyone,
My surgeon did the mammoprint at the time of the biopsy.  I was a bit concerned that the results came back as high probability of reoccurance.  I discussed this with the onc and he advised that all TN would have high prob. of reoccurance according to the Mammoprint. 


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DX 01/30/2010, 54 yrs., lump. 02/12/10, 5.2 tumor, 2 pos of 20 lymph nodes, TNBC stage IIIA, grade 3, BRAC 1/2 neg.


Posted By: dmwolf
Date Posted: Aug 08 2010 at 9:21pm
Jan, that's right.  Mammaprint is extremely conservative, and biases against most any ER- cancer.  I don't know if any TNs come out as low risk - actually, I'll check that out, and if I find out I'll let you know.

d


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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.


Posted By: caro36
Date Posted: Aug 09 2010 at 2:32pm
only 4% come out as low risk. c

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lumpectomy 9/2/08 6mm TN tumor
38 rads, 13 boost
6xTAC finished 04/10. BRCA1+ bill. mastectomy, imm. reconstruction using tissue exp 01/10


Posted By: Janrr6
Date Posted: Aug 09 2010 at 2:52pm
Thank you ladies.  This web site is such a great resource for all of us.  So many of you are very knowledgeable about all this stuff and can help those of us in need of advice.  Thanks, Jan

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DX 01/30/2010, 54 yrs., lump. 02/12/10, 5.2 tumor, 2 pos of 20 lymph nodes, TNBC stage IIIA, grade 3, BRAC 1/2 neg.


Posted By: Annie71
Date Posted: Apr 12 2016 at 2:38am
Concerning mamma print,mine came back low risk, so I will not have chemo. I was Dax March 1and had bilateral mastectomy,stage 1,grade2,ki67 was4%. I had estrogen sensitive bc in 2003. Had lumpectomy,radiation and took arimadex.


Posted By: Ssam
Date Posted: Apr 12 2016 at 10:15am
Hi Annie, please can you tell me how old you are? I have decided not to have chemo, but although most of the time I am happy with my choice, if I get low, the fear creeps in.  Just nearing the end of 20 rads, and I'm 50. Had 2 lumpectomies, in same place, and clean lymph. Thanks.

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Dx Dec 2015. Stage 1 Grade 2.
6mm tumour. No lymph nodes involved. No chemo. 20 rads. Age 50.


Posted By: Ssam
Date Posted: Apr 12 2016 at 10:17am
Hi Mary - what did your second opinion say? I have said no to chemo. My tumour was 6mm, apparently 3mm went up the biopsy needles and 3mm they got out at surgery! Mostly happy with decision but when I feel low the fear creeps in.  Thanks. x

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Dx Dec 2015. Stage 1 Grade 2.
6mm tumour. No lymph nodes involved. No chemo. 20 rads. Age 50.


Posted By: Annie71
Date Posted: Apr 12 2016 at 11:11am
Hi. I am 71..I have been avoiding meat except for salmon and other fish and also not eating any dairy products for three years.. I moved to a small town in me Oregon last year from Tempe Arizona..This town has a lot of seventh day adventists who are very healthy eaters and a lot of them work in the local hospital. It is a scarey decision to have or not have chemo. I hope it is the right decision for me..I will try to do the right diet and exercise and hope it will be all ok..good luck



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