Welcome New Members - Bisphosphonate takers: a test for ONJ risk

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Bisphosphonate takers: a test for ONJ risk

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Category: TNBC Forums
Forum Name: Welcome New Members
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URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=5245
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Topic: Bisphosphonate takers: a test for ONJ risk

Posted By: dmwolf
Subject: Bisphosphonate takers: a test for ONJ risk
Date Posted: Nov 20 2009 at 3:49pm

I saw this post on 'Inspire' and thought TNBCers taking bisphosphonates should know this:

Hello to ALL,

I saw my dentist yesterday for my 6 month check up and raised a lot of questions regarding ONJ.

It is a fear I have being on Zometa.

She is the first person to tell me this info. and I wanted to pass it on to you all. I had not heard of it before....

There is a serum blood test they can check to see what your risk would be to develop ONJ.

It is called the CTX Serum test.(c-terminal cross linking telepeptide) value.

So, if you are in need of any dental work etc...
You can have this level checked and it will tell you at what risk you are to develop ONJ. (osteonecrotic jaw).

values lower than 100pg/ml high risk to develop ONJ.

values between 100-150 pg/ml moderate risk

values above 150 pg/ml minimal or no risk.

normal values 400pg/ml.

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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.

Replies:

Posted By: 123Donna
Date Posted: Nov 20 2009 at 4:01pm

Denise,

Thanks, this is good information.

Donna

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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Posted By: unklez
Date Posted: Nov 20 2009 at 4:12pm

dmwolf wrote:

.....called the CTX Serum test.(c-terminal cross linking telepeptide) value. So, if you are in need of any dental work etc... You can have this level checked and it will tell you at what risk you are to develop ONJ. (osteonecrotic jaw).

Thanks Denise. This is very timely for us. Onty will be getting Zometa from Monday as a part of the clinical trial SWOG 0307. By the way her onco indicated that the risk of ONJ is 0.5% with bisphosphonates and this is mostly observed in people who need to have dental extractions.

After seeing your post, I googled this compound and found at least one mid sized study that confirms this.

http://linkinghub.elsevier.com/retrieve/pii/S027823910900175X - http://linkinghub.elsevier.com/retrieve/pii/S027823910900175X

It is good to know that if DW develops any dental issues that need extraction there is a test that can help evaluate the risk.

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Wife Dx: Jul/09. Age: 37. Size: 3cm. BRCA: -ve. Lumpectomy: Aug/09. Micromet 1/9 node. Chemo Start: Sep/09. E5103. DD ACB-> DD Abraxane (Taxol reaction). Zometa (S0307). Canadian Fraction Rads.

Posted By: HappyGoLucky
Date Posted: Nov 21 2009 at 2:29pm

thanks for the info Denise!