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Zometa for prevention?

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Topic: Zometa for prevention?

Posted By: Jason
Subject: Zometa for prevention?
Date Posted: Feb 11 2009 at 12:48am

Hi,

I've seen a number of posts in other other forums about taking zometa for prevention.

Is anyone doing that for triple negative BC? What's your thought on this? Do you think it's worth pursuing to get Zometa to prevent recurrence?

Replies:

Posted By: CarynRose
Date Posted: Feb 11 2009 at 2:30am

According the a report presented in San Antonio last year, Zometa appears to assist other chemo in effectiveness as well as disappearing bone mets.

My docs have me on Avastin/Zometa right now. Depending on the results of my PET scan on Friday, we may or may not add chemo to this mix.

Love,

Caryn

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Orig dx 6/03 - St.2a, IDC
gr.3,0 nodes, TNBC/BRCA1+
7/07 St 4 mets to nodes/lungs. PACA/Rads NED 11/07-10/08
Lepto mets 10/08
Rads for 4 brain tumors 4/10.
Leptomets return 6/10

Posted By: Jason
Date Posted: Feb 11 2009 at 7:13pm

I'm wondering if we should try to pursue this with the oncologist to pursue Zometa for early stage triple negative.

Any one else taking Zometa for prevention?

Posted By: trip2
Date Posted: Feb 14 2009 at 8:37am

Jason I pulled up a couple of articles and from what I can find it may help pre-menopausal women who have estrogen fed breast tumors.

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Stage 2 2003
Stage 1 2007
BRCA 1+

Posted By: dmwolf
Date Posted: Feb 14 2009 at 12:49pm

My understanding is that the data on this are encouraging, but not conclusive enough for most oncologists to prescribe it or (definitely) for insurance companies to pay for it. I think at the high recommended dosage it is around $1000/month or something around that. There are clinical trials, however, looking at bisphosphonates for all breast cancers. In some of those studies, Zometa is the only drug, in others, there are three being looked at - Zometa, ibandronate, and clodronate. I'm in the latter trial, and was randomly assigned to clodronate, an older generation bisphosphonate. The trial provides whichever bisphosphonate you are assigned to for free for three years. It is put out by SWOG (S0307, I think). One thing to keep in mind is that these drugs are powerful and not without risk. Jaw necrososis is a very real possibility, especially for the IV bisphosphonates like Zometa. And it can be hard on kidneys/liver. So....you might want to check out the clinical trials. You'll see that the data is encouraging but pretty mixed. Another thing about the clinical trials - you have to sign up within a certain window of standard treatment. If you do neoadjuvant, the SWOG study required starting within 12 weeks of finishing surgery, which for me coincided with the day after I finished radiation.

Good luck,
Denise

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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.

Posted By: trip2
Date Posted: Feb 14 2009 at 2:33pm

Thank you Denise,

Your post was interesting. Good luck to you in your treatments and keep us updated, will ya?

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Stage 2 2003
Stage 1 2007
BRCA 1+