Welcome New Members - KEYNOTE 522

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KEYNOTE 522

Printed From: TNBC Foundation
Category: TNBC Forums
Forum Name: Welcome New Members
Forum Description: A place to introduce yourself to our community
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=13897
Printed Date: Mar 26 2026 at 12:20pm
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Topic: KEYNOTE 522

Posted By: Lobster37
Subject: KEYNOTE 522
Date Posted: Jan 11 2025 at 3:18pm

Hello, Brand new here, Jan. 2025

Looking to communicate with someone who has been on, or is on the KEYNOTE 522 Regimen for TNBC.

Recently diagnosed, and have not started any treatment, but apparently this KEYNOTE is the new standard of care for TNBC.

Please please respond if you are in this. I am very scared.,

thanks

Replies:

Posted By: Ceeps
Date Posted: Feb 08 2025 at 3:59pm

Hi Lobster,

I had to look up what Keynote 522 was, but yes I’ve had it. July - December 2024.

I had 12 weeks of Pembro + taxol and carbo (every week) and then 12 weeks of Pembro + AC (dox + cyto) - every 3 weeks.

I wouldn’t say it’s a laugh, but I also managed fine. I worked throughout (from home, but I always work from home) and got out walking most days and seeing friends a bit. Although they mostly came to me!

If I can help with anything, just let me know.

Posted By: Lobster37
Date Posted: Feb 09 2025 at 1:52pm

Thank you for your response. I am into my 4th week and doing OK thus far. Hair coming out much sooner than expected,

Posted By: Ashley
Date Posted: Feb 22 2025 at 3:10pm

I was on this course. For me, the taxol was perfectly fine. The ac was a bit harder. The week I got first ac was rough. I recieved meds on Tuesday. And by the following Sunday I was admitted to the hospital for chemo induced sepsis. My numbers dropped to a mere 50 white blood cells. But 5 days, some antibiotics and shots to boost cell production, i was good to go. I wish you all the best. If you have any specific questions, I'd love to answer them for you.

Posted By: GoBlue24
Date Posted: Mar 01 2025 at 5:00pm

Hi, I just finished this regimen a few weeks ago. I was also able to work from home through it all. I will say the first AC was the toughest. I already had a sinus infection, so I ended up in the hospital with neutropenic fever. Please be sure to communicate with your nurses and doctors any time you feel sick or anything not right.

I’m praying your treatment goes well! Please let us know if you have any questions. I’m happy to connect and help through anything. Good luck!