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new large study TNBC neo adjuvant vs adjuvant

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Forum Name: Let's Talk About Chemotherapy
Forum Description: A place to discuss Chemotherapy
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=13799
Printed Date: Mar 26 2026 at 4:36pm
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Topic: new large study TNBC neo adjuvant vs adjuvant
Posted By: SagePatientAdvocates
Subject: new large study TNBC neo adjuvant vs adjuvant
Date Posted: Feb 25 2021 at 10:52pm
Dear TNBC family,

This large study (19,000 plus women) was brought to my attention this evening. The study seems to indicate that OS Overall survival was better in the women who were treated with adjuvant chemo (post surgery) rather than with neo adjuvant treatment (prior to surgery). It is also clear that women who had a PCR  (Pathologic Complete Response) had better overall survival. The main problem it seems that women with neo adjuvant treatment had a disappointing PCR. The study also brings up the need for more research on the biology of TNBC.

with my love to all here,

Steve  

https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0222358/1/pone.0222358.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210226%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210226T033722Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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" rel="nofollow - https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0222358/1/pone.0222358.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210226%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210226T033722Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates


Replies:
Posted By: 123Donna
Date Posted: Feb 26 2021 at 11:08am
Hi Steve,

Thanks for sharing this information.  I couldn't get the link to work.  Do you have a name of the study?  If so, I could try and search for the link and post it for you.

Donna


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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Posted By: SagePatientAdvocates
Date Posted: Feb 26 2021 at 1:13pm
Thanks Donna

Does this help?

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0222358&type=printable" rel="nofollow - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0222358&type=printable


-------------
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates


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