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Has anyone taken Xeloda after AC/T?

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Forum Name: Let's Talk About Radiation Therapy
Forum Description: A place to discuss Radiation Therapy
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=13652
Printed Date: Apr 06 2020 at 1:52pm
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Topic: Has anyone taken Xeloda after AC/T?
Posted By: Monarch
Subject: Has anyone taken Xeloda after AC/T?
Date Posted: Jan 10 2020 at 9:47am
Wondering if anyone has taken Xeloda (pill form) after AC/T?  The side effects are concerning, especially the hand and foot syndrome and mucositis.  The mucositis was horrible for me during the ACT, and my feet have terrible neuropathy from the Taxol.

If so, can you give me some pointers on how to lessen the symptoms?  

Monarch


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DX IDC, Metastatic Stage III, 6/6/2019, Nodes pos, 5.6 x 3.3 x 3.5 left breast. Ki-67 90%. AC x 4, T x 12, Partial Mastectomy and Targeted Axillary Dissection, Thyroidectomy,



Replies:
Posted By: JC104
Date Posted: Jan 10 2020 at 11:43am
I'm on round 5 of 6 of Xeloda after Dose Dense AC x 4 and 14 rounds of weekly Taxol with 2 rounds of Carboplatin added at the end. I had really bad side effects the first round of Xeloda & my MC reduced my dose & that helped substantially! I still am getting dryness & peeling on my hands &feet but using Aquaphor & Udder Balm is helping tremendously. I started on 2,000 mg twice daily the first round but once they reduced it to 1500 mg twice daily it has really helped with the bothersome side effects. I also avoid spicy foods & drinks as they tended to bother my mouth. Once I cut out spicy & very salty foods I haven't had any more mouth ulcers. My mouth still gets tender towards the end of week 2 but it is much more tolerable. 


Posted By: Kellyless
Date Posted: Jan 13 2020 at 11:37am
Did you continue to be bald or lose your hair on it JC104?

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IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!


Posted By: JC104
Date Posted: Jan 13 2020 at 12:16pm
Unfortunately I suffered permanent hair loss from TC (Taxotere/Cytoxsn) from my first diagnosis in 2010. What hair I have does not seem to grow like normal since I've been on Xeloda, it does grow, but much slower than when I wasnt on Xeloda. 


Posted By: sophie
Date Posted: Jan 14 2020 at 7:14am
hi JC104, why you taking xeloda after radiation. Did they assume you have residuals?

I am in xeloda for 2 cycles, 1 st is fine , 2nd experience hands and feet issues... a bit of upset stomach as well... I did sugery first so no way of verifying if I have any residuals ... I asked my MO to issue me xeloda for preventive care. Are you the same reason?

Regards,

Sophie 


Posted By: JC104
Date Posted: Jan 14 2020 at 10:59am
I had radiation in 2011 during my first occurrence. This occurrence my tumor did not respond to the AC/T with Carboplatin, it actually grew so I was told since mine did not respond I needed to take Xeloda for 4-6 rounds depending on how I tolerated it. Since I'm tolerating it well the goal is 6 rounds. 


Posted By: Monarch
Date Posted: Jan 16 2020 at 10:05pm
for those that took Xeloda or are taking it, 1500 mg BID?  Do you mind me asking height and weight?  My MC instructed I take 5000 mg a day, during radiation.  

Monarch


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DX IDC, Metastatic Stage III, 6/6/2019, Nodes pos, 5.6 x 3.3 x 3.5 left breast. Ki-67 90%. AC x 4, T x 12, Partial Mastectomy and Targeted Axillary Dissection, Thyroidectomy,


Posted By: JC104
Date Posted: Jan 16 2020 at 10:12pm
My specialty pharmacist said 2000 to 2400mg BID is the standard dose (4000 to 4800 daily). I started out at 4000mg per day (2000 am and 2000 pm) but had pretty bad side effects so my MO reduced my dose to 1500 BID (3000 daily) I'm 5'10" 153 lbs 


Posted By: sophie
Date Posted: Jan 16 2020 at 10:22pm
I am doing the same 3000 per day ... I am asking to do 2 week on,1 week off, 8 cycles... I had and hand feet weird feeling and skin very dry... a bit stomach upset and fatigue... 



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