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Is it TNBC if 20% of cells are Her2+?

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Topic: Is it TNBC if 20% of cells are Her2+?
Posted By: dono7392
Subject: Is it TNBC if 20% of cells are Her2+?
Date Posted: Dec 03 2019 at 6:39pm
Doctors want to treat me with chemo designed for both TNBC and Her2+ because about 20% of my tumor is just above equivocal amplification for Her2.. I would imagine that they have to pick one type of cancer to treat before deciding treatment. Has anyone else experienced this?



Replies:
Posted By: FullTilt
Date Posted: Dec 04 2019 at 9:17am
There is a new Trial which is have been having amazing results. They have reduce the circulating tumor cells in metastatic TNBC to undetectable in the first patient and shrank the tumor size! These are the cells travel through the blood spreading the tumors to other parts of the body. Earlier this year they reduce the metastasis in their mouse model by 98%. Now they are proving they can stop metastasis in humans and control tumor size. This is huge news! The small cloth and body has very few side effects and we’ll toxicity!

https://www.cytodyn.com/newsroom/press-releases/detail/367/cytodyn-reports-early-results-from-first-patient-in-its" rel="nofollow - https://www.cytodyn.com/newsroom/press-releases/detail/367/cytodyn-reports-early-results-from-first-patient-in-its


Posted By: strongtogether
Date Posted: Dec 05 2019 at 4:02am
That really sounds amazing! What 0hase are.the trials?


Posted By: FullTilt
Date Posted: Dec 05 2019 at 9:26am
Sorry my post was auto corrected incorrectly. It should say ‘monoclonal antibody’ in the last sentence. Leronlimab has been tested in over 800 patients with no serious adverse events and few side effects. The trial is now open to all metastatic triple negative breast cancer patients- email me at rwshay@hotmail.com or the 
CEO directly at npourhassan@cytodyn.com

Dose anyone know how I can post this trial as a topic it needs to be discussed on your forum? I think it can help many here!


Posted By: strongtogether
Date Posted: Dec 05 2019 at 8:06pm
I'm sorry fulltilt but I don't understand.
Do you work for Cytodyn, or are you a patient of theirs or what?
Does all tnbc have CCR5? Is it used for treating stage4 patients currently?


Posted By: Kellyless
Date Posted: Dec 05 2019 at 8:14pm
For clarification, the 800 patients mentioned are HIV patients. It looks like they've had one or two stage 4 TNBC patients maybe? I can only find information published by Cytodyn themselves, and yes they are a for profit venture. FullTilt, please reach out to the site administrator and get clearance to promote your information here to our TNBC cancer survivor community. Thank you. 

-------------
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!


Posted By: 123Donna
Date Posted: Dec 05 2019 at 8:27pm
Fulltilt,

Your study only looked at 2 TNBC metastatic patients and looked at circulating tumor cells?  I think a study that is a huge breakthrough needs to be much larger than 2 people.  What are the end points of the study?  Did it only look at circulating cells?  Did the tumors completely become no evidence of disease?  What happened when they stopped the study drug?  Did the tumors start growing again?

This thread was talking about someone who's tumor was TNBC but also had a portion that was Her2+.  Your study would not benefit this person so I'm not sure this is the appropriate place to post.  You should get permission from the admins about posting in the Metastatic forum.



-------------
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15



Posted By: FullTilt
Date Posted: Dec 08 2019 at 1:23am
I have been trying to get the admins to help me post this trial in the appropriate place. This monoclonal antibody will likely help any metastatic breast cancer patient. The trial only has two patients enrolled so far but the 8 week results of the first patient are stunning and they are screening patients right now and hope to have more enrolled by the end of the year.

The primary end point is progression free survival but one secondary endpoint is a reduction in circulating tumor cells. In the first patient the circulating tumor cell have been reduced to undetectable after only 8 weeks of treatment and the tumor size has shrunk.

They have not stoped the study drug yet as it is early in the trial so I do not know if the tumor will start to grow again.

https://clinicaltrials.gov/ct2/show/NCT03838367?term=Leronlimab&cond=Triple+Negative+Breast+Cancer&cntry=US&draw=2&rank=1" rel="nofollow - https://clinicaltrials.gov/ct2/show/NCT03838367?term=Leronlimab&cond=Triple+Negative+Breast+Cancer&cntry=US&draw=2&rank=1


Posted By: 123Donna
Date Posted: Dec 08 2019 at 11:12am
Fulltilt,

You can start a new thread (topic) under the Metastastis section.  It will get better viewing if it was a stand alone topic.

https://forum.tnbcfoundation.org/tnbc-metastasis-recurrence-users_forum5.html" rel="nofollow - https://forum.tnbcfoundation.org/tnbc-metastasis-recurrence-users_forum5.html


-------------
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15




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