Let's Talk About Chemotherapy - Xeolda vs Carboplatin

Xeolda vs Carboplatin

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Category: TNBC Forums
Forum Name: Let's Talk About Chemotherapy
Forum Description: A place to discuss Chemotherapy
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=13344
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Topic: Xeolda vs Carboplatin

Posted By: PinkWarrior
Subject: Xeolda vs Carboplatin
Date Posted: Apr 28 2018 at 1:03pm

Any advice much appreciated. I went through my AC chemo in Nov and Dec with no problems. Started Taxsol in Jan and made it through 2 doses of that before we had to stop because of liver functions tripled and I went into SVT. I started a new one called Taxotre My tumor started growing so we only did two of those and I then had a bilateral mastectomy. Unfortunately the final path only showed 15 % response. Which I am not surprised because he grew after it had shrunk with AC. It also showed some Metplasia cells. Which I ended up having a CT of my chest abd and pelvis and that was clear. Now I will either get Xeolda or carboplatin after my radiation is complete. My question is has anyone been in a study with one or thee other. I see a lot of people have taken carboplatin as part of there treatment. How did it treat you. I would only have to complete 4 doses of it. I would appreciate anyone’s advice comments.

Replies:

Posted By: Kellyless
Date Posted: Apr 28 2018 at 1:40pm

With TNBC Carboplatin is usually given with Taxol. With you doing it alone that would be a consideration. That would be a question I'd pose to the Dr's, how much has Carboplatin given alone been tested, versus Xeloda which I think is usually given alone?
Just a thought...

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IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!

Posted By: rstar
Date Posted: Apr 28 2018 at 6:05pm

Hello there,

Since you had a response to A/C and both Carboplatin, Adriamycin and Cyclosophomide are DNA damaging agents, then I would start with Carboplatin (onc would probably give u 4 cycles of that) and continue with Xeloda as a maintenance therapy. Xeloda should be given for 6 months at the most according to Create-X trial.

Posted By: 123Donna
Date Posted: Apr 30 2018 at 8:00am

Hi PinkWarrior,

There have been some threads talking about these two agents. I'll post some links for you to look at:

http://forum.tnbcfoundation.org/capecetabine-xeloda-vs-carboplatin-displaying_topic12974_post130380.html" rel="nofollow - http://forum.tnbcfoundation.org/capecetabine-xeloda-vs-carboplatin-displaying_topic12974_post130380.html

http://forum.tnbcfoundation.org/xeloda-after-neoadjuvant-chemotherapy-and-surgery_topic13153_post131617.html" rel="nofollow - http://forum.tnbcfoundation.org/xeloda-after-neoadjuvant-chemotherapy-and-surgery_topic13153_post131617.html

http://forum.tnbcfoundation.org/adding-carboplatin-increases-pcr_topic11688_page1.html" rel="nofollow - http://forum.tnbcfoundation.org/adding-carboplatin-increases-pcr_topic11688_page1.html

http://www.nejm.org/doi/full/10.1056/NEJMoa1612645" rel="nofollow - http://www.nejm.org/doi/full/10.1056/NEJMoa1612645

http://clinicaltrials.gov/ct2/show/NCT02445391" rel="nofollow - http://clinicaltrials.gov/ct2/show/NCT02445391

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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15