Print Page | Close Window

Therapy options (newcomer)

Printed From: TNBC Foundation
Category: TNBC Forums
Forum Name: Welcome New Members
Forum Description: A place to introduce yourself to our community
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=13232
Printed Date: Aug 11 2020 at 12:03pm
Software Version: Web Wiz Forums 12.01 - http://www.webwizforums.com


Topic: Therapy options (newcomer)
Posted By: Aleksandra
Subject: Therapy options (newcomer)
Date Posted: Nov 24 2017 at 7:17pm
Hi. My friend has just been diagnosed with the TNBC.
She is 67 years old and 48x40mm tumour at her right breast.

Histology revealed: invasive non-specific cancer G3. ER 0%, PR 0%, no HER2, "negative overexpression", Ki67-65%


What are the standard treatment protocols and are there promising clinical trials like with atezolizumab or pembrolizumab?

What is the current stage of the disease?



Thank you!



Replies:
Posted By: 123Donna
Date Posted: Nov 25 2017 at 12:45pm
From the size of the tumor, it looks like your friend is most likely stage 2, but that could change if there is spread to lymph nodes or chest wall.  Here is a chart on tumor staging:

http://ww5.komen.org/BreastCancer/TumorSizeandStaging.html" rel="nofollow - http://ww5.komen.org/BreastCancer/TumorSizeandStaging.html

This is the NCCN Guidelines for Breast Cancer.  It's a comprehensive guide from diagnosis to treatment:

https://www.nccn.org/patients/guidelines/stage_i_ii_breast/index.html" rel="nofollow - https://www.nccn.org/patients/guidelines/stage_i_ii_breast/index.html

The most common therapy in the US is dose dense AC followed by T, or T followed by AC.  There are other regimens and even studies about adding Carboplatin to T improves outcome with neoadjuvant treatment.  Here are few couple of links to look at:

https://www.nccn.org/patients/guidelines/stage_i_ii_breast/index.html#54" rel="nofollow - https://www.nccn.org/patients/guidelines/stage_i_ii_breast/index.html#54

http://forum.tnbcfoundation.org/adding-carboplatin-increases-pcr_topic11688_page2.html" rel="nofollow - http://forum.tnbcfoundation.org/adding-carboplatin-increases-pcr_topic11688_page2.html


http://tnbcfoundation.org/state-of-the-art-tnbc-treatment-brochure/" rel="nofollow - http://tnbcfoundation.org/state-of-the-art-tnbc-treatment-brochure/

http://www.cancernetwork.com/oncology-journal/new-therapeutic-strategies-triple-negative-breast-cancer" rel="nofollow - http://www.cancernetwork.com/oncology-journal/new-therapeutic-strategies-triple-negative-breast-cancer





-------------
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15




Print Page | Close Window

Forum Software by Web Wiz Forums® version 12.01 - http://www.webwizforums.com
Copyright ©2001-2018 Web Wiz Ltd. - https://www.webwiz.net