Aggressive enough?
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Category: TNBC Forums
Forum Name: Let's Talk About Chemotherapy
Forum Description: A place to discuss Chemotherapy
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=12100
Printed Date: Mar 26 2026 at 7:32pm
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Topic: Aggressive enough?
Posted By: lizziealberta
Subject: Aggressive enough?
Date Posted: Jun 30 2014 at 4:50pm
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In 09, I was diagnosed with ER+ node neg BC. Had C/T, rads, AI, and currently NED for the ER+ cancer. In April during a regular MRI, a lymph node lit up in my arm pit. It's TNBC. A case review at Moffitt Cancer Center found the cancer in 09 was misdiadnosed by the pathologist. It was an ER core with a TNBC shell. If I had A/C/T in 09, we might not be here but my oncologist wanted to save me the potential for heart issues since I am an athlete. Fast forward 4.5 years and I feel like he is again being too conservative, reccommending 4 rounds A/C (just finished) then abraxane. I have been reading the ISPY study and feel carbo/taxol and potentially also avastin are called for. The consulting oncologist at Moffitt agrees with me. I am not sold on avastin but am sold on the carbo. I am no shrinking violet. I know how to handle my oncologist but the issue is: what is the right choice? Do I try for a third opinion to break the stalemate? What If I push hard and choose wrong? I am made of steel but I assure you, I cannot do this a third time. Help
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ER+ misdiagnosed 09, was ER+/TNBC,lumpectomy, C/T, rads, AI. TNBC in node 4/14, in neoadjuvant A/C then carbo/gemzar, complete path response. double mastectomy.
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Replies:
Posted By: 123Donna
Date Posted: Jun 30 2014 at 4:59pm
Just my two cents, I'd add the Carboplatin, but skip the Avastin. Here's a link to some studies showing Carbo increases pcr, but not so much good news on Avastin and too toxic.
http://forum.tnbcfoundation.org/adding-carboplatin-increases-pcr_topic11688.html" rel="nofollow - http://forum.tnbcfoundation.org/adding-carboplatin-increases-pcr_topic11688.html
You can always get a third opinion if it will make you feel better. I got 3 for my radiation treatment with my recurrence. Sometimes we're trying to make the best decision, not really knowing how our tumor's will respond.
Donna
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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Posted By: lizziealberta
Date Posted: Jun 30 2014 at 5:27pm
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I have a PET scheduled for Monday to see how I have responded to the AC. But from my standpoint, even if it looks clean as a whistle, I would prefer to do the carbo. Thanks for the heads up on avastin
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ER+ misdiagnosed 09, was ER+/TNBC,lumpectomy, C/T, rads, AI. TNBC in node 4/14, in neoadjuvant A/C then carbo/gemzar, complete path response. double mastectomy.
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