Let's Talk About Chemotherapy

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Taxol Treatment

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Forum Name: Let's Talk About Chemotherapy
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Topic: Taxol Treatment

Posted By: JulieKCA2013
Subject: Taxol Treatment
Date Posted: Apr 03 2013 at 6:23am

Now that I am half way through AC I have to find something new to worry about. ;) The doctor has said I will be doing the dose dense biweekly treatment of Taxol, 4 times. Reading online the 12 weekly Taxol treatment is the standard procedure. Did anyone have the 4x Taxol and did your doctor give you the 12 week option and the benefits? Or vice versa?

Thanks so much ahead of time.

-Julie

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Replies:

Posted By: debB
Date Posted: Apr 03 2013 at 8:34am

I was told they do the 12 because the benefits are the same but the SEs are easier to tolerate. Don't know if that helps...

-------------
Dx 4/29/11, 46 yrs old, 3.9 cm tumor, Stg 2 Grade 3 chemo 4 rounds DD AC, 12 weekly taxol, finish. Lumpectomy, 2mm residual tumor. 37 rounds rads completed. Cisplatin/PARP trial

Posted By: Natalie
Date Posted: Apr 03 2013 at 10:34am

I did the 4 Taxol bi-weekely. No I was not given the option of 12. The only option I was given was doing my Taxol every 3 weeks instead of 2.

-------------
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg

Posted By: JulieKCA2013
Date Posted: Apr 03 2013 at 11:03am

Deb I read that about side effects. How were yours with taxol. I am reading it is a beast on fatigue. Was it known that you were TNBC when they did the chemo? I will talk to my doctor about it next time. Was just curious. Natilie my doctor might be saving that discussion for when we are actually close to the treatment :).

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: beck
Date Posted: Apr 03 2013 at 11:34am

back in 2007 when i had er postive i did the 12 weeks of taxol, a women i met did four weeks , she had numbness in her feet for years, i had no long turm side effects.. she wished she would of done same as me, my hair even started going back while on it .... beck

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ER postive in 2007 10 nodes in underarm,primary unknown, right side, did chemo and rad. Dec. 2011 TN left side 1.5 CM no nodes stage 1 did cmf chemo and rads.

Posted By: Lee21
Date Posted: Apr 03 2013 at 1:57pm

There is not a single standard of care treatment protocol, more likely it is institution-dependent. There are basically 3 "standard" treatment regimens for TNBC (MD Anderson has its own regimen and I've never been able to get a rational explanation for why they do things the way they do).
1) DD AC -> DD Taxol (every 2 weeks x 4 cycles each)
2) DD AC -> weekly Taxol x 12 weeks
3) TAC (Taxotere, A, C every 3 weeks x 4 cycles)

In terms of head on comparison of benefits re: Taxol
1) CALGB 9741 study -- Taxol every 3 weeks vs Taxol every 2 weeks. Taxol every 2 weeks is better in terms of disease free survival and overall survival.
2) ECOG study reported in the NEJM 2008 -- Taxol every 3 weeks vs weekly Taxol. Weekly Taxol is better.

No comparison of weekly vs every 2 week Taxol to my knowledgment.

In terms of toxicities, comparisons between weekly Taxol vs every 3 week Taxol:
weekly Taxol better in terms of myelosuppression (bone marrow toxicity) but worse in terms of neurotoxicity.

In my opinion, it is better to stick with the regimen that the hospital is most familiar with, since there are no data comparing weekly to every 2 week Taxol. I was given Neulasta throughout my DD AC-T. I had some numbness in my fingers and toes that progressed throughout treatment, then got better when treatment was completed. But then I received cisplatin and the neuropathy got worse. Nothing so bad that it interferes with anything I do, just something I know is there.

12 weekly Taxol vs 2 week Taxol means 8 more infusions. If you don't have a port, it will be a challenge.

In terms of who gets severe neuropathy, most likely it is dependent on your genetic makeup. For example, they have found certain polymorphisms in beta-tubulin III to predispose to severe toxicities. It is an active field of investigation since in some patients, neurotoxicity is dose limiting.

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: Lee21
Date Posted: Apr 03 2013 at 1:59pm

System wouldn't let me edit my post.
I introduced a new word: knowledgment -- you know what I mean.

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: Lillie
Date Posted: Apr 03 2013 at 4:56pm

Dear Julie,

In 2006, when I had my taxol, I think the weekly x 12 was not done that much. It was only after that when it became a more human way to administer the taxol.

I did 4 dose dense taxol treatments after my 4 dose dense A/C. I was in a clinical trial that added gemzar 4 dose dense along with the taxol. I did have bone pain, neuropathy in hands and feet and my hair did not grow back in. But I got through it and have been NED for almost 7 years.

Good luck and God Bless,

Lillie

-------------
Dx 6/06 age 65,IDC-TNBC
Stage IIb,Gr3,2cm,BRCA-
6/06 L/Mast/w/SNB,1of3 Nodes+
6/06 Axl. 9 nodes-
8/8 thru 11/15 Chemo (Clin-Trial) DD A/Cx4 -- DD taxol+gemzar x4
No Rads.
No RECON - 11/2018-12 yrs NED

Posted By: Mlm746
Date Posted: Apr 03 2013 at 5:26pm

Julie,

I was treated with 4 AC and 4 taxol in 2011. I noticed some neuropathy that progressed with each treatment. It was nothing that I couldn't handle and was pretty much gone 6-9 months post treatment. Apparently nerve cells take longer to regenerate. I did have a rare side effect of bone and joint pain, but this was well managed after my first dose with pain meds. My advice if you have pain, take the Meds to get you through your program. I did and was happy to be finished. My hair grew back pretty quickly..4-6 months and the fatigue was worse towards the last two treatments...but that is also after the AC. You sound like a fighter...keep up the good work and God Bless...you can do this!!!!!!

Posted By: Katdoll
Date Posted: Apr 03 2013 at 9:28pm

I did 4 AC every other week and 4 taxol every other week. Nobody discussed doing taxol every week. If they had, I think I would have preferred to do the 4. Wouldn't have wanted to extend chemo by another month. I found the taxol to be WAY more tolerable than the AC. No nausea or feeling sick. I found I needed more sleep during that time, but I functioned fine during the day - worked full time, kept up with exercise, etc. I had neuropathy in hands and feet that was tolerable and improved a lot after treatment ended and was gone around 6 months later.

-------------
Tested positive for BRCA1 mutation (187delAG) in 4/09 @ age 44; BSO 9/09; diagnosed w/TNBC in 10/09; 1 cm Stage 1 TNBC IDC, grade 3 + 1.5 cm DCIS; BMX 11/09, nodes clear; chemo (AC/T).

Posted By: debB
Date Posted: Apr 03 2013 at 11:20pm

Julie,

I had neoadjuvant chemo and yes, they knew it was TN. Taxol was way easier than A/C, not as tiring for me. Unfortunately, I have had some type of reaction with every chemo drug. My first Taxol I was fine and out of the blue vomited several times. As a result, they insisted that I have Benadryl with each infusion and IV Benadryl knocks me on my butt! I did not have Neulasta shots with Taxol, and at least with doing weekly infusions, had no problem with blood counts.

As far as the neuropathy, I took B vitamins, L-Glutamine and L-Carnitine to help. I did not start noticing neuropathy until near the end. I still have some very mild neuropathy in my toes but also had Cisplatin on a trial and that made it worse again.

Good Luck!
Deb

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Dx 4/29/11, 46 yrs old, 3.9 cm tumor, Stg 2 Grade 3 chemo 4 rounds DD AC, 12 weekly taxol, finish. Lumpectomy, 2mm residual tumor. 37 rounds rads completed. Cisplatin/PARP trial

Posted By: JulieKCA2013
Date Posted: Apr 04 2013 at 12:01am

Hi Lee, I did read both those studies when I was searching the Taxol regimen. Sounds lik e everyone's experience rings similar, more tired than AC plus neuropathy but better than AC on nausea end. I will talk to my doctor but I am sure she will have a very good reason for her plan and I will stick with her. Plus the biweekly is better on the work/kids/school schedule. Thank you again ladies you are a fountain of knowledge. <3

Posted By: cheeks
Date Posted: Apr 04 2013 at 12:02am

Dear Julie,

I wasn't the best chemo patient and my oncologist said she was afraid i wouldn't do it if i got sick. I had 12 weekly Taxol and my A/C was given every 3 (not 2) weeks.

Take care and keep drinking plenty of liquids.

Blair

-------------
Lump found 11/08
DX: 2/09 @52 TNBC
L. Mast. 3/26/09, SN-, BRCA-,
4.5 cm (post surgical)T2NOMO
Chemo: 4/09-10/09 Taxol x 12,
A/C x 4, No rad.No recon. NED 1/17. New Primary right breast TN, 2/2018.

Posted By: bay
Date Posted: Apr 04 2013 at 6:54pm

I had DD treatments of AC then Taxol. I also read about the 12 weekly treatments toward the end of mine and worried if I should have had that course of treatment. I just finished treatments this week. I agree with everyone's statements that Taxol causes more fatigue but less nausea than AC.

This site is wonderful. It seems whenever I have a question, the answer is found quickly here.

-------------
IDC Stage 2, grade 3
DX 11/15/2012 @ the age of 40
Dose dense Neoadjuvant Chemo AC/ T started 12/13/2012
Lymph node involvement
BRCA 1/ BRCA 2 neg

Posted By: MarissaK
Date Posted: Apr 07 2013 at 12:31am

Julie,

I never knew the 12 weekly sessions to be the "standard". On the contrary, my oncologist told me I'd be having the standard DD bi-weekly x4 treatments (same as A/C method) from the beginning. My onc said if I had taxol 1/wk for 12 wks instead of the DD format that the neulasta injection would be waived (because weekly doses are a lesser dose). Hence, the side effects are lessened and the wbc booster is not needed. I was tempted to have it weekly at first, just at the thought of eliminating that booster! But, my onc personally recommended sticking to the DD method to get it over with quicker and get surgery scheduled sooner. (If you've already had surgery, this doesn't matter.) At first I thought that maybe the weekly option was more effective (since it actually results in slightly more ml of medication over the course of treatment). However, my onc assured me that research indicates there's no difference in outcomes for either regime. So, it's really just a matter of what works best for you.

Personally, I'm glad I stuck to DD and just got it over with. For me, there was something comforting about getting a bigger dose all at once. Plus, I wanted to have surgery asap.

Good luck with whatever option you choose.

-------------
DX 5/18/12 at age 34. Stage IIIC IDC TNBC, grade 3, 3 cm (multiregional nodal involvement). DD ACT complete 9/5/12. BMX 10/15/12, ALND: 0/12 nodes. pCR. Rads x 25 + 3 boosts completed 2/6/13. BRCA neg

Posted By: weekender09
Date Posted: Apr 22 2013 at 3:20pm

For those of you that did the Taxol (i start a week from today) how was the constipation side effect with it? Any better than AC? My routine is one week of chemo sickness and one week of terrible hemorrhoids that is excruciating. Hoping for some relief with the Taxol since my counts don't allow me to heal.

Also Deb B: Did they prescribe the B vitamins, L-Glutamine and L-Carnitine or was that your research?

Barb

-------------
02/12/13 DX TNBC, Grade III, Stage 3, 3.3cm tumor, IMN and 1 lymph Positive, Chemo A/C T complete 6/13
BRCA1-/BRCA2+ Variance, BIL 7/13, 33 RADS complete 10/13 Remssion :)

Posted By: Grateful for today
Date Posted: Apr 22 2013 at 3:54pm

Barb,

I had posted on another thread some general info on taxanes and will repeat here as a FYI.
For those preparing for taxane chemo or having chemo now:
Some additional thoughts for consideration, for discussion with the oncologist.
For taxane chemo:
[ paclitaxel (Taxol)      docetaxel (Taxotere)        albumin-bound paclitaxel (Abraxane) ]
- Consider Vitamin B6 100 mg daily.    Check with oncologist.
       Consider starting one week prior to taxane (if possible).
       Continue thru taxane treatment. Some recommend continuing 6-12 months after taxane stopped.
    Vit B6 may decrease/prevent peripheral neuropathy type symptoms.
    Wide range of peripheral neuropathy symptoms from taxanes.
    Many who do get peripheral neuropathy symptoms with taxanes find they do decrease after
        taxane completed.
    Keep provider informed of any neuropathy symptoms.
    Some providers allow other supplements , some allow only Vit B6.
          Most providers do not allow anti-oxidants during chemo.   (Usual exception: Vit D3 and Vit B6)
    If foot/toe numbness, be aware of potential safety (hot water) and balance issues.
    Again, VERY important to check with YOUR oncologist about any vitamin, supplement etc
            during chemo.
One might like to take a look at esp. on pp 7-10 (there info and discussion on taxol) on:
     http://forum.tnbcfoundation.org/newly-diagnosed_topic9432_page7.html" rel="nofollow - http://forum.tnbcfoundation.org/newly-diagnosed_topic9432_page7.html
             (In addition, there's good info and discussion on the entire thread on other matters.)

Regarding your question specifically re: taxol and constipation, in my experience, I did not find
   that to be an issue.

Hoping you will be a minimalist when it comes to Taxol side effects.

With caring and positive thoughts,
Grateful for today..........Judy

Posted By: MarissaK
Date Posted: Apr 22 2013 at 7:24pm

Barb,

Omg, I had major constipation and hemorrhoid issues on the A/C as well (For me that was worse than the nausea). At least with the nausea you can combat it pretty good w/the meds. As far as Taxol is concerned, yes, it was much, much better. Still had some issues at times, but nothing like on the A/C. My oncologist told me that constipation is the biggest complaint on the A/C! Hopefully the Taxol will be easier on you as well. I did have extreme bone/joint pain on Taxol, so for me it was a trade off. Try doubling up on the milk of magnesia and docusate softgel stool softener, this helped me a lot. Also, proctozone works good on the hemorrhoids. This is a prescription you'll need to ask your doctor for, but I'm sure he/she will be happy to oblige. Good luck.

-------------
DX 5/18/12 at age 34. Stage IIIC IDC TNBC, grade 3, 3 cm (multiregional nodal involvement). DD ACT complete 9/5/12. BMX 10/15/12, ALND: 0/12 nodes. pCR. Rads x 25 + 3 boosts completed 2/6/13. BRCA neg

Posted By: debB
Date Posted: Apr 22 2013 at 8:17pm

Hi Barb,

I guess I always thought the constipation was from the pre-meds and not the chemo itself. I started treating with Miralax at least the morning of to, if not the day before and stayed on for several days.

The vitamins are research that I did. Now that I think about it, I also did a Vitamin E in the mix. I didnt start to experience neuropathy until well into my 12 treatments, and it was only ever mild. Bothersome and annoying vs. a real problem.

Most women find Taxol easier... We will hope that is the case for you too!

Deb

-------------
Dx 4/29/11, 46 yrs old, 3.9 cm tumor, Stg 2 Grade 3 chemo 4 rounds DD AC, 12 weekly taxol, finish. Lumpectomy, 2mm residual tumor. 37 rounds rads completed. Cisplatin/PARP trial

Posted By: Lillie
Date Posted: Apr 22 2013 at 8:32pm

Hi Barb,

I found taxol easier to deal with than A/C. I had the bone and joint pain, but constipation, nausea, and such were minimal, or not at all. Also my appetite was much better during taxol.

Good Luck and God Bless,

Lillie

Posted By: JulieKCA2013
Date Posted: May 01 2013 at 2:22am

Glad to join the club, AC is done for me! Had my last treatment last night now I am on to taxol. I talked to my doctor about the L-Carnitine, L-Glutamine and B vitamins. She told me not to take the L-Carnitine, but ok to take the L-Glutamine and B vit. She said they did a study at U of Mi and there was no seen advantage of taking it, and actually there was an adverse reaction but it could have no relation. She also reiterated not to take any extra C or E since they are antioxidants and may work against what the chemo is trying to do, destroy tumor cells.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: fiddler
Date Posted: May 14 2013 at 11:38am

Speaking of taxol....

How much will it reduce the risk of recurrence?

I've read in several places it's only 1%. I'm thinking of quitting after 4 of 12 weekly infusions because of the side effects.

Two weeks after completing AC I developed neuropathy in my fingertips. It has since (5 weeks and 4 taxol infusions later) gotten worse and this week spread to my toes. It's very painful - I can't open jars or turn on lamps by turn knobs - hurts too much. My fingernails are distorted - I'm wondering if they're lifting off the beds. Also discolored. The pains in my muscles and joints is very difficult 3-5 days after infusion (and then I turn around and get another one). I developed very itchy hives on the backs of my hands after the last two infusions. No energy. Weak like I can't believe.

Does anyone know what the stats are on quitting early?

Posted By: Lee21
Date Posted: May 14 2013 at 2:16pm

Here is a discussion on the use of acetyl-l-carnitine in preventing taxane-induced peripheral neuropathy ( http://www.clinicalneurologynews.com/index.php?id=9985&type=98&tx_ttnews%5btt_news%5d=136562&cHash=da03e20e36%29" rel="nofollow - http://www.clinicalneurologynews.com/index.php?id=9985&type=98&tx_ttnews[tt_news]=136562&cHash=da03e20e36) .
There were actually two trials, the one in the US reported no improvement and possibly worsened symptoms; the one conducted in China reported improvements.
There was an earlier but smaller and non randomized Italian study where they did neurophysiological studies and reported improvement with the use of carnitine ( http://www.ejcancer.com/article/S0959-8049%2805%2900429-6/abstract" rel="nofollow - http://www.ejcancer.com/article/S0959-8049%2805%2900429-6/abstract ).
One significant difference is that the US trial treated patients for 24 weeks whereas the one in China treated patients for 8 weeks. The Italian study used pre-treatment findings as controls for post-treatment findings.

I think the jury is still out as to whether ALC is useful in preventing taxane induced neuropathy.

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: Annie
Date Posted: May 14 2013 at 2:29pm

        Hi Fiddler, I am sorry you are experiencing such effects from taxol. I do not know the stats that you are asking about. I am surprised at the 1% stat you mention in regards to taxol and recurrence.

                     I was under the impression is was significantly higher but someone may come along with the exact information on it.

                     I am totally surprised that more cancer clinics are not using ice packs to prevent the possible side effect of neuropathy so often occuring when taxol is infused.   This has been used with great results in many clinics. I myself while taking taxol had my hands and feet both wrapped in ice packs and towels. One could remove them for a minute or two here or there for a bit of relief. I have had miniscule problems, a little bit of the odd nail fracture, in very minute form and only years after the infusion. Maybe you could ask for this during your treatment even if you had to carry in your own makeshift ice packs.

                      Were you given benadryl and some other drug, forgotten the name just now, its been a while. I was because I thought I felt flushing in the chest area during the first treatment.

                      It would be best to consult with your Onc. and go over every aspect you can before making a decision on this.

                      Hang in there and hope you get some relief and good sound direction from your Onc. take care...Love, Annie

-------------
Annie TNBC Stage IIA Gr 3 1cm lesion 2/5 lymph nodes+ lumpectomy,FEC & D 30Rads finished(08/2009) BRCA- Chronic Cellulitis due to Radiation-- L.Mastectomy Jan 2012

Posted By: Lee21
Date Posted: May 14 2013 at 2:44pm

Fiddler, I am not sure there are statistics of the kind you are asking. In general, I think completing treatment on dose and schedule is considered critical to reaping maximal benefits. In my case, I had neoadjuvant chemo and my tumor hardly responded to AC (by MRI after 4 cycles); there was a response to Taxol although not complete.

Some possibilities.

I have heard that neuropathy is worse with the weekly than the dose dense regimen. Can you ask to switch over to the dose dense regimen? The standard dose dense regimen is Taxol 175 mg/m2 x 4 cycles, 2 weeks apart.

You can also ask for dose reduction.

Taxotere is another possibility in terms of alleviating some of the allergic SEs since those to Taxol is to the carrier (Cremophor) that Taxol is dissolved in. On average, neuropathy is reported to be less with Taxotere. Taxotere is given every 3 weeks for 4 cycles. In the TAC regimen (T=taxotere, all 3 given together), febrile neutropenia (fevers due to low WBC) is worse compared to DD AC->T (T=Taxol). Not sure about Taxotere by itself.

As for alleviating some of the allergic SEs, you should be getting Benadryl and Decadron (steroids) on the day of infusion and Decadron for the subsequent 3 days to reduce allergic SEs.

For what it's worth, the peripheral neuropathy improves after completion of treatment.
Muscle pain is caused by Taxol and it does pass. Bone pain is exacerbated by Neulasta but if you are on the weekly regimen, you're probably not taking Neulasta.

For most of us, it's a matter of gritting our teeth and getting through it. Depending on the individual's genetic makeup and other medical problems, SEs could be limiting.

It would be worthwhile having a heart-to-heart with your oncolgoist and seeing what the options are.

Good luck.

Lee

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: Natalie
Date Posted: May 14 2013 at 3:29pm

I wish i had known of the ice water thing for feet & hands with Taxol.

Nails discolored and yes came off with Taxol.

The bone pain sucks really bad, no meds they gave me worked well for it. Although the pains did get much better all this time out I do still get some pains here & there :(

I associated the pain not with Taxol but with the Neulasta shot.

Hope you feel better soon.

Natalie

-------------
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg

Posted By: JulieKCA2013
Date Posted: May 14 2013 at 10:46pm

I started Taxol today. I am feeling good tonight, much better than how I felt on AC. On AC I felt like alice falling in the rabbit hole to a world of double gravity.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: fiddler
Date Posted: May 15 2013 at 12:35am

The neuropathy came on before i was on taxol. It was a reaction to adriamycin. The neuropathy is very painful.

Posted By: JulieKCA2013
Date Posted: May 15 2013 at 5:19am

Lee when I asked my doctor about taking Decadron the three days after they told me I did not have to like I did on AC. I was happy about that I do not like Decadron it makes me very hyper and anxious. As far as the neuropathy issues with taxol, when it is taken biweekly as a dose dense formula do you have on the off treatment week any relief or is it constant? Is this an option for you to change to fiddler so you only have 2 more treatments to get through then you are done? I agree with Lee talk to your doctor he/she is there to help you manage these SE.

<3 Julie

Posted By: fiddler
Date Posted: May 15 2013 at 9:55am

JulieKCA2013,

My doc said my body probably wouldn't be able to take the high dosage. However, there are two other alternatives - abraxane and taxotere - neither of them use cremophor, which is what I may be allergic to. I think they all cause neuropathy, though people don't feel like the drugs are killing them. I'll talk over the alternatives.

Posted By: Kellyless
Date Posted: May 15 2013 at 11:13am

After my first taxol (4x every two weeks) my doc had me do the ice bath on my hands and it worked perfectly. Double glove both hands, a basin of ice water and plunge in once the infusion starts. When it starts to hurt pull them out for a few minutes, then back in. No further neuropathy and no more nail lifting. I got a little tingly in my feet, Dr said we could ice them too but it never got that bad. It's so easy, everyone should try it.

-------------
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!

Posted By: annafriday
Date Posted: May 15 2013 at 8:45pm

Barb,

I have always had a slow digestive system and this was the first ive seen someone mention constipation with ac. Did you do anything or take anything to help with that. I have been thinking about taking senna or something to help.I want to take something before it gets too bad. Guess I need to ask my doctor what is ok. I hate to say after my first AC I am trying to find data about one or two doses of ac and the survival outcome. It is so hard to do something that makes you feel sick when I felt completly healthy until surgery and chemo. My tumor markers are good. This nausea is bad even with the meds. Im trying to stay strong.

-------------
DX:3/20/13 right breast multifocal stage 3a TNBC. Bilateral Mastectomy 4-18-13 largest tumor 6.2cm. 1 microscopic sentinal node positive. KI-67 77%. ACx4..doing Taxol now x12 weekly.

Posted By: JulieKCA2013
Date Posted: May 15 2013 at 10:28pm

Anna I had bad constipation/hemis with AC. The first treatment I was on colace 2 times a day. My doctor switched me to senna and that helped. AC made me very sick the first 4/5 days but I was better after that. You will get through it, stay strong.

Posted By: Natalie
Date Posted: May 16 2013 at 12:10am

Barb,

I was told by my gastro that Sennacot is addicting to the colon. He told me to take Miralax. You are very strong for just making the decision to go through treatment, remember that.

natalie

-------------
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg

Posted By: Lillie
Date Posted: May 16 2013 at 9:47am

I drank an 8 oz. glass of warm prune juice on the day of treatment and for 3 or 4 days following. I also took Sennacot, starting the day of treatment.

I will add that I did not do anything to prepare for constipation with the first A/C treatment and I had the worst constipation I ever want to experience.

You only take the Sennacot for 2 or 3 days, at most, with each treatment, and then the bowels usually return to more normal. So, I don't believe this would be enough to get addicted to it. Also the stool softeners are good. I know many people who use, or used, them.

You just have to stay ahead of the constipation after each treatment.

Love and God Bless,

Lillie

Posted By: JulieKCA2013
Date Posted: May 22 2013 at 10:07pm

Ok ladies, I have a tiny bit of neuropathy in my fingers after my first Taxol. I really only have one finger that seems to be really affected my right hand pointer. Of course the one I use the most. I was googling and found this article. What do you think? My dad is diabetic and has a ton of lancets. I may try it.

http://simplehorse.blogspot.com/2012/05/simple-treatment-for-taxol-chemotherapy.html" rel="nofollow - http://simplehorse.blogspot.com/2012/05/simple-treatment-for-taxol-chemotherapy.html

Posted By: JulieKCA2013
Date Posted: May 23 2013 at 8:11am

I don't know why anyone would recommend a person on chemotherapy to do that though, it would be highly susceptible to infection and slower healing.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: babymelany
Date Posted: Jun 04 2013 at 11:24pm

Eeeekk!! Help!!!

I just started Taxol last week and I think based on what I read in the thread that what I am feeling is "normal"...?

My right "pointer" toe feels numb and painful (I've tried to massage it and that helps for a few minutes). I think by bone pain it is the constant aching/tingling feeling like when one gets the flu? I felt fine while on AC, nust very tired and I was under the impression I would not be as tired, but this change (I started last Friday) has got me feeling horrible! I can't move without some tingling or ache somewhere in my body kicking in (including the bottoms of my feet, ugh). I started a B-Complex vitamin because I thought that would help, but it isn't. I feel bloated and my stomach aches when I eat and I pee almost a green color - this can't be good, right?? Maybe I should be drinking more water amoung other things......is this normal? Is there anything to relieve these symptoms while in treatment or do I just grin and bear it?

(I've rarely ever had even a cold so I'm not sure how to even handle all these new "feelings" and I may be overreacting)

On the bright side - only 3 more treatments left.......?

-------------
SINGLE MOM OF 2,BRCA1+ Lump 11/12,DX 1/24/13 BC @age 36 (2 days B4 bday),3/5/13 Double Mast,Stage 2, Grade 3, 3.4 tumor 0/6 nodes
AC/T 4-7/13,Rec-chest wall 9/12,Proton 10-12/13,CT NED 1/14,Rec-5/14

Posted By: JulieKCA2013
Date Posted: Jun 05 2013 at 8:24am

This is how I am on Taxol. Find the day of and day after. 2 days aftler I am a little tired and a little achy. 3 days after it feels like I ran a marathon, very achy plus tired. 4th day most of the aches are gone but bring on the bone pain. 5th day after I start to feel better a little bone pain. 6th day I am almost normal maybe a twinge of bone pain here and there. My pointers are numb also, but they seem to be better the second week.

baby if you are like me and you started Friday, monday it would have been worst on Monday and Tuesday. What color is your B vitamin complex? Mine is a bright yellow. It makes my pee bright yellow. :) You may need some more fluids. Hope you turn that corner soon and have better days before your next treatment. Hang in there.

-Julie

Posted By: JulieKCA2013
Date Posted: Jun 05 2013 at 8:24am

Find = Fine in the message above.

Posted By: Natalie
Date Posted: Jun 05 2013 at 8:45am

babymelany,

When I switched to the Taxol, my Oncologist and I deduced that it was the Nuelasta injections that were causing the bone pain. I had deep bone pain mostly all over, but more profoundly from the hips down. Nuelasta did not bother me at all while on AC.

As far as the bottoms of your feet go, I experienced both the bottoms of my feet and palms of my hands feeling very hot & painful, once again the feet worse then the hands. I had trouble even just sitting in a chair and having my feet rest obn the floor. The tissues were red and inflamed. If I remember correctly it started at the end of AC. Quite funny how I can't recall now, since it was such a big deal for myself. The tissues did shrink and stop hurting, and then the peeling started.

Always speak to your Onc or the NP about your symptoms.

Natalie

-------------
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg

Posted By: Lillie
Date Posted: Jun 05 2013 at 9:25am

babymelany,

First I had 4 dose dense A/C infustions bi-weekly. I had a neulasta shot after each treatment and I did ache, felt bad, couldn't eat, chemo brain, etc. Second I had 4 dose dense Taxol/Gemzar infusions bi-weekly. I had a neulasta shot after each treatment. I began to feel better mentally and my appetite got better, BUT on the 3rd, 4th, 5th days the bone pain in my legs and back was bad. I do believe it was the taxol, as the pain and aches with the previous treatments were different, not so intense and almost debilitating at times. It gets better after the treatments end. Just takes time.

God Bless,

Lillie

Posted By: angelgirl
Date Posted: Jun 05 2013 at 4:13pm

I just finished my chemo 4 1/2 weeks ago. I am going through radiation right now. I had 4 doses of A/C then 4 does of Taxol bi-weekly. Before I started with the Taxol I had a nurse tell me that taking claritan everyday helps with the bone pain. I checked with my Dr and she gave her ok for me to try it. It worked for me, I hardly had any bone pain! I did get other side effects such as nail problems and numbness in my hands and feet but that is slowly getting better.

Posted By: Grateful for today
Date Posted: Jun 05 2013 at 11:47pm

Hi,

Lee just posted on the Open Access thread:
http://forum.tnbcfoundation.org/open-access-links-articles-tnbc_topic9440_page9.html" rel="nofollow - http://forum.tnbcfoundation.org/open-access-links-articles-tnbc_topic9440_page9.html
   ASCO 20132: Dose dense Taxol vs. weekly Taxol, no difference in survival.
    http://www.medpagetoday.com/HematologyOncology/BreastCancer/39636" rel="nofollow - http://www.medpagetoday.com/HematologyOncology/BreastCancer/39636
The article included the following   Action Points:
- This study was published as an abstract and presented at a conference.
   These data and conclusions should be considered to be preliminary until published in a peer-reviewed
   journal.
- Breast cancer patients obtained the same disease control with less toxicity when they received weekly
   low-dose chemotherapy with paclitaxel instead of a higher dose given every 2 weeks.
- Note that the two regimens had similar rates of grade 3/4 toxicity, but the weekly regimen was
   associated with more hematologic toxicity, whereas the dose-dense regimen led to more allergy-related
   reactions, musculoskeletal pain, and neuropathy.
In the article:
   "The results could have a practice-changing impact on breast cancer management, Andrew Seidman,
    MD, of Memorial Sloan-Kettering Cancer Center in New York City, said during an ASCO press briefing.
    A supporter of the dose-dense approach developed at Sloan-Kettering, Seidman said he plans to
    start treating patients with the weekly regimen."
    Note:   the word "could"

"Budd noted that patients randomized to dose-dense paclitaxel received six cycles of therapy (instead of the usual four) so that patients in each group continued treatment for a total of 12 weeks."

Can any one help me understand how this study "could" be practice changing when dose dense taxol
is given x4 doses and not 6 doses as in the study?
What effect, if any, would 4 doses (instead of 6) have on side effects and on overall survival?

Would some one help me explain what is meant by:
"Since this was not conducted as a noninferiority study, we cannot make a statistical conclusion about the lack of difference," Budd said during his presentation to ASCO attendees. "However, the Kaplan-Meier curves and computed hazard ratios suggest little difference between the two arms." means.

Wasn't sure whether to have posted these questions on the OPEN ACCESS thread or on this taxol
treatment thread.
Any thoughts if a discussion of an article is better on OPEN ACCESS
                                                                                  or on a related thread
                                                                                  or could be either?

Thanks.

Grateful for today............Judy

Posted By: Lee21
Date Posted: Jun 06 2013 at 10:52am

Just posted the actual abstract in OPEN ACCESS.

total dose of ddPx6 = 1050 mg/m2
total dose of ddPx4 = 700 mg/m2
total dose of weeklyP = 960 mg/m2

So by making it 6 doses, the two arms are more equivalent in total amount. I'm not sure how this relates to the usual ddPx4 which was the regimen in the original DD paper (Citron et al. JCO 21:1431, 2003). I was always concerned about the difference in total Taxol dose administered between weeklyP vs. ddPx4.

Note that this trial also had patients on ddACx6 and then were switched over to ddACx4: as stated in the abstract, AC randomization was halted for futility.

If you do a Google search for non inferiority study, it brings up a number of useful links. I find the link to a pdf and a ppt to be quite helpful.

I think there will be discussions/commentaries on this result. If you come across any, please post.

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: JulieKCA2013
Date Posted: Jun 12 2013 at 12:36am

One last taxol to go for me on June 25th. They scheduled my surgery date for my bmx, july 17. It was very unnerving to get a date so soon. Again something new to worry about. :)

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: babymelany
Date Posted: Jun 14 2013 at 12:49am

Natalie -

Yes!! I had no issues with the neulasta shot prior to the Taxol. The only new thing with me was the pain was so intense I could hardly sit as well - nothing seemed to ease the ache and no position worked. Sleep was not even an option as I kept waking up through the nights! Then the sides of my feet started peeling. I can't remember if I mentioned it or not, but one of my toes was in pain and then it went numb until probably 7 days later. When I say number, I mean it felt like someone wrapped a large band-aid around it way too tight! I'm not sure which toe it actually was which was so bizarre - but I know it wasn't a very important one like the big or little toe. Just one of those middle toes ;) It was okay this week, but I go back tomorrow for my 2nd of 4 does. Almost halfway done with Phase 2. Yay me! I made it this far!! :)

lillie - thanks.I am very focused on knowing it gets better after the treatments end. I even willing to let the toe go numb for 3 weeks (one week after each treatment is numb) to get through it and pray that is the worst of issues. *fingers crossed* *prayers sent*

angelgirl - thanks! I am going to ask about the Claratin this time.

**On a side note - when I went for labs last week my white cell count (chemo brain terminology?) were so high that I was told I might not have to get the shot. I had to go for an extra blood draw last night. I'm not sure how I feel about that. Has anyone been able to skip the Nuelasta injections? Is this good, bad or indifferent?

Posted By: debB
Date Posted: Jun 14 2013 at 11:48am

I had Neulasta with my A/C and had weekly Taxol with NO Neulasta shot and did not have a problem at all with white counts.

-------------
Dx 4/29/11, 46 yrs old, 3.9 cm tumor, Stg 2 Grade 3 chemo 4 rounds DD AC, 12 weekly taxol, finish. Lumpectomy, 2mm residual tumor. 37 rounds rads completed. Cisplatin/PARP trial

Posted By: kirby
Date Posted: Jun 14 2013 at 10:56pm

Nuelasta was not protocol when I had tx but then neither were ports. This was before dose dense and extended tx. As you can see by my signature 4 X AC was tx du jour in 2001. My 2 cm tumor was considered borderline but stage 1 whereas now i see by others signatures it may be considered stage 2.

If you do a search there have been threads where many felt much better not having the nuelasta.

-------------
kirby

dx Feb. 2001. Age 44
Lumpectomy

2cm. no nodes stage 1 grade 3

4 rnds AC, 35 rads

Posted By: suew
Date Posted: Jun 18 2013 at 9:52pm

Two more rounds of taxol lefr. The numbness in my toes and fingers seem worse but aleve helps. Howblong does it take until you have less fatigue? Next step is surgery and radiation.

Posted By: Lillie
Date Posted: Jun 19 2013 at 6:33pm

Dear Suew,

Welcome to the TNBC Support Group. So sorry you have a need to be here.

It sounds as though you are on the home stretch with chemo. Good Luck.

I can't say how long it will take to get your energy back. The chemo zaps your energy and so does the radiation. With the surgery in between it could be after all treatments before you really begin to get your energy back. I had surgery first and then chemo. It took about a year for me to begin to feel I was regaining much strength. I started back working full time, began a walking program and it took a lot more sleep and rest for me to function. It does get better with time.

Good Luck and God Bless,

Lillie

Posted By: ctlindah
Date Posted: Jun 20 2013 at 3:11pm

Thanks for the info Lillie,

I've been wondering how long the fatigue will last, I sure do need a lot more sleep than I did before. Also wondering when the pain in my hips that makes me feel like I'm 100 years old when I get out of a chair will start to fade. Guess I just have to be a bit more patient.

Linda

-------------
DX IDC TNBC 10/12 age 48, Stage 1, Grade 3, 1.5cm
Lumpectomy DD AC & Taxol BRCA- rads X30 finished 5/13

Posted By: Katdoll
Date Posted: Jun 20 2013 at 4:39pm

I had AC/T. About three weeks after the last Taxol I had a huge boost in energy levels and it felt great. After that there was a slow increase over about six months till I reached my new normal. I say "new normal" because my energy level has never gone back to what it was, but IMO it is not the chemo that caused this, rather having my ovaries removed shortly before being diagnosed with TNBC and not being able to do any hormone replacement therapy. Despite the energy deficit, I feel great and still have as much or more energy than anyone my age that I know.

I hand numbness/pain in feet and fingers during Taxol, though not as bad as some people describe. Again, there was a huge improvement about three weeks after my last Taxol and then it was about six months before it completely went away. I don't have any now, except for some reason when I get sick and have a fever. Then I do feel numb in my toes and bottoms of my feet.

-------------
Tested positive for BRCA1 mutation (187delAG) in 4/09 @ age 44; BSO 9/09; diagnosed w/TNBC in 10/09; 1 cm Stage 1 TNBC IDC, grade 3 + 1.5 cm DCIS; BMX 11/09, nodes clear; chemo (AC/T).

Posted By: Natalie
Date Posted: Jun 20 2013 at 4:43pm

Sorry guys that I have to add my input on various side effects and all. I am not saying it will be the same for everyone, as I have seen many threads where people are doing really well and went back to feeling like themselves physically.

Before treatment, I had the usual bodyaches that can come with age and too little selfcare. I was rough on my back in my early 20s at one of my jobs, but seemed to get a lot better years later with my attention to care.

After treatments I still have chemo brain, actually seems to have gotten worse over time. I was a pretty detail oriented lady before. Not to go into too much detail but I have been the primary cvaregiver of my son since injury in 2008. Working very hard at maintaining therapies, equipment, his eligibility for the supports he is entitled to.

After treatment I am haveing a horrible time recovery my mental clarity to get back on board full strength. My mind is so busy all the time with all sorts of things on all levels that I have a hard time doing simple things.

As you can see by my signature I finished treatment in October 2011, and I still have deep bone pain at night sometimes when I tried to be very productive in the day. My all over body aches have gotten worse also, I do not remember feeling this bad even last year. As a matter of fact I know I didn't. Arthritis blood work comes back negative. I have to say, I feel like an arthritic ridden 90 year old now. I can't even close my fingers in the morning for a while. I sit down for even a few minutes, when I go to get back up everything cracks & aches so bad. I waddle like a baby trying to take her first steps. Once I get moving aI am alright.

My stamina is gone with the wind also.

I am no longer the multitasking dynamo I once was.

Am I glad I had treatment? Yes Would I do it again? I really doubt it. There is a feeling a person gets that is very important also, that is quality of life. I feel very strongly that if I had to go through treatment again I would choose not to.

I take many supplements to help this machine, I think it helps but honestly not really sure. I do Yoga when freedom to allows ( I am still primary caregiver of my son). The yoga really helps in the short term, now if I could just go every day I actually might feel better more often then not.

I have been told, it was not the chemo, hmmm bulldinky I know it was. I have been told it is the chemo induced menopause, hmm maybe some of this but no way in heck is it even 1/4 of it. All the excuses in the worlld serve no relief in the fact that the treatment hurt my quality of life.

I am very sorry if this scares anyone that is going through treatment now, but I feel so comfortable with everyone here that good bad or indifferent I can share how I feel.

It is very important to be informed in my opinion on all fronts. I feel beaten down now, and all of the peoplle around me & in a few groups that I went to during are not here to help me function in my life. I feel very alone, angry & sad at everything at times.

Natalie

-------------
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg

Posted By: Lillie
Date Posted: Jun 20 2013 at 9:45pm

Dear Natalie,

I am sorry life has taken such a toll on you. With all the obligations that are placed on you, you don't have time to feel better.

You sound as though you are terribly depressed. Did you know that Depression hurts. Maybe you could check with your doctor and get some help with this. There are drugs that help depression and pain at the same time. My husband was on cymbalta for about four years after a bout with shingles which led to depression. It really helped him a lot.

I am not trying to push anything on you, but WE ALL would like to hear that you are feeling better. Keep us posted.

Love and God Bless,

Lillie

Posted By: argynnis
Date Posted: Jun 21 2013 at 12:16pm

A quick question about the pre-meds you got to take before Taxol:
What is the typical steroid dosage you take - is it normal to take steroids 12-6h before the infusion or is it enough to take some just before the infusion starts? My oncologist ordered a really high dosage and I do not really want to take them as I would not be able to sleep. For my AC I only took 1 steroid pill just before the infusion and I was fine.

-------------
TNBC, IDC 4.5cm, Grade 3, 3/27 lymph nodes - Stage 2B
Mastectomy (right)
4xDD AC + 4 T

Posted By: TriplePositiveGirl
Date Posted: Jun 21 2013 at 1:39pm

Hey Nat,

I am sorry to hear that you are struggling so. We all are dealing with the aftermath of treatment in some fashion - some worse than others. I believe that the chemo I received made me feel like I aged quicker than normal. To be thrust into early menopause takes it toll on the body (and the mind!). It has taken me a long time to adjust to this, and there are times that I get really angry about it and question whether chemo was the best choice or not. At the time, I didn't feel like I had a choice. The doctors were all championing chemo as a first line defense for this particular cancer, regardless of the staging. Unfortunately, hindsight is 20/20. The only solace I take away from this experience and the treatment route I chose is that I did so thinking what might be best in the long term. I traded the fear of the unknown for the potential long term side effects. All in all, for me, at least, I have managed to adjust and get myself to a better place by taking it day by day and not expecting me to be the person I was BEFORE the cancer diagnosis. That person is gone, replaced by a new version of myself. In some ways, a stronger version. There are times I miss the old me. I cry. I get mad. I feel cheated. But in the end, I am still here, and alive. I am thankful to be alive, as things could have gone a different direction too.

I would give you a big hug if I could. Hang in there girl. You have given lots of good advice to others here on this forum, now it is time to take good care of yourself. :)

Lisa

-------------
Diagnosed Jan 2010; Stage IIa, grade 2, 3.2cm in rt. breast, no nodes and BRCA-. 4 cycles Carbo/Gemzar 3/10; Lump 6/10; 2 cycles carbo/gem after surgery 8/10; 35 Rads finished 12/1/10. NED.

Posted By: JulieKCA2013
Date Posted: Jun 25 2013 at 4:47pm

In 20 minutes I will be done with my last taxol and done with chemo. It was not easy peasy but it was worth it. Good luck to the rest of you ladies on your journey.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: Lillie
Date Posted: Jun 25 2013 at 5:17pm

Hi Julie,

Congratulations!

Right about now you should be finishing the taxol or maybe getting uphooked from your port.

I am so glad you were able to finish well!!!

God Bless,

Lillie

Posted By: kirby
Date Posted: Jun 26 2013 at 1:06am

Congrats Julie.

-------------
kirby

dx Feb. 2001. Age 44
Lumpectomy

2cm. no nodes stage 1 grade 3

4 rnds AC, 35 rads

Posted By: ctlindah
Date Posted: Jun 26 2013 at 9:31am

Hi Julie,

That's great news! So glad that's behind you.

Linda

-------------
DX IDC TNBC 10/12 age 48, Stage 1, Grade 3, 1.5cm
Lumpectomy DD AC & Taxol BRCA- rads X30 finished 5/13

Posted By: katiedidit
Date Posted: Jun 26 2013 at 3:00pm

I was about to ask you ladies to tell me about Taxol, but this thread is so helpful. I had my last of four A-C bi-weekly treatments last Friday (6/21) and will start Taxol next week (July 3 to avoid the holiday). The last two A-C treatments left me with more fatigue than the first two. Still working and running my business, but need naps in the pm this week and last week.

I was told that there is no Neulasta for the Taxol treatments, but a bunch of pre-meds like benedryl (which makes me loopy), Pepcid (?), and some others. Four Taxol treatments to go, with the last on Aug 16. I will inquire about vit B6 to see if it is recommended. Hoping to have smooth sail through it, but we all find our bodies react differently.

Any Taxol advice is appreciated.

Posted By: ctlindah
Date Posted: Jun 26 2013 at 3:08pm

Hi Katie,

I found Taxol easier than A-C, but as with A-C it's cumulative. By the end you'll be really ready to be done with it if you're anything like me. But then we're all different. I hope you sail right through it.

Linda

-------------
DX IDC TNBC 10/12 age 48, Stage 1, Grade 3, 1.5cm
Lumpectomy DD AC & Taxol BRCA- rads X30 finished 5/13

Posted By: Katdoll
Date Posted: Jun 26 2013 at 6:37pm

I had neulasta after Taxol, but I think different hospitals have a different approach on this.

Before the first Taxol infusion they gave me a mega-dose of Benadryl and also the usual doses of steroids. The combination drove me batty - feeling sleepy/lethargic (Benadryl) and wired/jumpy (steroids) at the same time doesn't seem possible, but it is, and I hated it. For the second time I asked if they could lower the Benadryl dose since I'd proven I wasn't allergic to the Taxol, and they obliged. It did help a bit to have less Benadryl.

-------------
Tested positive for BRCA1 mutation (187delAG) in 4/09 @ age 44; BSO 9/09; diagnosed w/TNBC in 10/09; 1 cm Stage 1 TNBC IDC, grade 3 + 1.5 cm DCIS; BMX 11/09, nodes clear; chemo (AC/T).

Posted By: suew
Date Posted: Jun 26 2013 at 10:03pm

Last taxol treatment tomorrow woo hoo. MRI is scheduled for monday results will depend on mastectomy.

Posted By: JulieKCA2013
Date Posted: Jun 26 2013 at 10:37pm

Thank you so much for reminding me of the Neulasta. With the weekly treatments they do not do Neulasta, but if you are on DD then I believe you will have Neulasta. I added claritin to my regimen, it does seem to help with the bone pain.

Good luck with Taxol. I found it easier, just when the muscle pain hit I was a little fatigued for a few days. Expect days 3-5 after treatment to take it easy.

Posted By: JulieKCA2013
Date Posted: Jun 27 2013 at 5:59pm

Okay one more side effect of taxol, nail lifting. I noticed some discoloration of my nails last week and this week there are two that seem to be lifting just a bit at the ends. Reading online it can continue to get worse even after treatment is ended. Does anyone have experience with this?

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: Mimis
Date Posted: Jun 27 2013 at 10:17pm

Im about in the same boat- just finished the 4 AC and start Taxol on July 5th- anybody here have allergic RX to Taxol- that seems to be a concern! Making me a bit nervous, although i have never had an allergy to any meds.....

Posted By: tracyinva
Date Posted: Jul 03 2013 at 12:54am

I got 2 more treatments before I move onto Taxol. My question is it the norm to take 5 pills 12 hours then another 5 pills 6 hours before. I would have to get up at 4:30 just to take my pills if thats the case. What do they actually do?

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: tracyinva
Date Posted: Jul 03 2013 at 12:55am

My has become so soft since I started chemo is that normal? Also, I started crying today for no reason out of the corner of my eye lids? Can that be a side effect from chemo?

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: JulieKCA2013
Date Posted: Jul 03 2013 at 8:00am

5 pills of what tracy? I had the tearing eyes the last two treatments of A/C. Doc said it was a side effect drying my eyes. She recommended tear drops to moisturize but make sure it doesn't try to relieve redness.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: Mimis
Date Posted: Jul 03 2013 at 8:09am

I m taking 5 pills of decadron the night before and morning of Taxol- total 20mg- its a steroid to lessen chance of allergic rx

Posted By: argynnis
Date Posted: Jul 03 2013 at 1:16pm

I started Taxol on Monday and I did not take any steroids or allergy medication the night before. I got a steroid, benadryl and pepcid infusion just before the Taxol and it was ok - only the beandryl hurt my veins as it went in. No allergic reaction. I will ask them to lower the steroid dose next time (I think i got 20mg).
So far the only side effect are runny eyes and nose.

-------------
TNBC, IDC 4.5cm, Grade 3, 3/27 lymph nodes - Stage 2B
Mastectomy (right)
4xDD AC + 4 T

Posted By: suew
Date Posted: Jul 03 2013 at 6:48pm

Hi, I had 12 rounds of taxol no reactions. Just body aches 3 days after the treatment Aleve worked the best. God bless

Posted By: tracyinva
Date Posted: Jul 07 2013 at 11:46pm

I am having sever watery eyes that run down through my nose. I am going to pick up some saline tomorrow . I have one more DD AC then Taxol. I have 5 pills I have to take 12 hours before then another 5 six hours before. That means getting up at 4am to take the pills on chemo days. i just hope its easier than AC.

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: tracyinva
Date Posted: Jul 07 2013 at 11:48pm

i hate wearing wigs..they itch my head and am just going to buy a one of those head wraps. It's too hot and honestly I'm not one to be shy about showing my battle scars. Oct 7 is my last chemo . Every day I mark off another day until I am chemo free

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: tracyinva
Date Posted: Jul 07 2013 at 11:50pm

Does anyone else get the steroid when they have done AC and it feels like pricks all over your body? The first time I got it it was very very painful in my private area. Does anyone know what causes that. I didn't get my period last month but got it this month. I am so worried chemo pause although I know i have no control over it.

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: Mimis
Date Posted: Jul 08 2013 at 12:20am

If they push the steroid too fast it will cause the burning vaginal pain but if given very slow will lessen or eliminate that feeling

Posted By: tracyinva
Date Posted: Jul 08 2013 at 12:40am

yeah I had the nurse do that last time but some of the nurse are not as nice and the last nurse I had she was such a sweetheart and did it really slow and talked to me and helped me through it by doing it so slow I barely felt it.

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: tracyinva
Date Posted: Jul 14 2013 at 11:32pm

I had a question about Taxol. 5 pills 12 hours before and 5 pills 6 hours before. Saying my chemo time is 10 am. Is it really anal that you have to take them at exactly the correct time. Can I do it within an hour. If I wake up at 4 a.m. to take the pills I will never be able to get back to sleep despite the 1mg ativan they gave me or should I just ask them for some sleep medicine.

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: Mimis
Date Posted: Jul 14 2013 at 11:46pm

My oncologist just said the night before and morning of and didn't give specific time so I would say taking at 5am would be just fine. The way I see it they don't start it the minute I get there anyways.

Posted By: Mimis
Date Posted: Jul 15 2013 at 12:01am

My first dose of Taxol caused 6 days of leg/foot pain. Started on Day 3 and lessened up day 6 and was gone by day 8- it was severe- could hardly walk a couple of days- anybody else have this? They said they may have to lessen the dose- can cause permanent damage- that would be terrible!

Posted By: hopeful57
Date Posted: Jul 17 2013 at 10:33am

4x DD Taxol vs. Taxol 1x 12 weeks????. My Oncologist threw me for a loop yesterday. We were on a plan to do the 4DD Taxol once every 2 weeks. I finished AC yesterday, and she mentioned that some new research said that the weekly Taxol x12 showed a 1-2% better something? I didn't really hear the rest--all I could think of was my plans were to be over by early September and the thought of going an extra month as well as to the hospital an extra 8 times was about too much for me. She said I am low risk--1.2 cm, no lymph node involvement, clear margins (up to 8 mm., everything else is good, so she said we should stick with the 4x, but it was her duty to let me know that there is some new resarch out there. We are going to go with the 4x, but now I am second-guessing myself. Does anyone know of this new research. What do you think? ANy guidance would be appreciated. Thanks,

Posted By: Lee21
Date Posted: Jul 17 2013 at 12:04pm

There's an abstract presented at ASCO 2013 that compared Taxol DDx6 vs Taxol 12 weekly and found no difference in survival ( http://www.medpagetoday.com/HematologyOncology/BreastCancer/39636" rel="nofollow - http://www.medpagetoday.com/HematologyOncology/BreastCancer/39636 ). However we don't know about the survival benefits of Taxol DDx4 vs Taxol 12 weekly. There was an older study looking at Taxolx4 given every 3 weeks vs Taxol 12 weekly and Taxol given every 3 weeks was considered inferior ( http://www.ncbi.nlm.nih.gov/pubmed/18420499" rel="nofollow - http://www.ncbi.nlm.nih.gov/pubmed/18420499 ).

My personal bias is that with Taxol 12 weekly you get a higher cumulative dose (960 mg/m2 vs 700 mg/m2 for Taxol DD x 4) and that might be better in the long run (no data that I know of to support that). Also, you don't need the Neulasta shot for weekly Taxol and I believe, lesser neuropathy with the weekly regimen compared to dose dense (but neuropathy was more frequent compared to Taxol given every 3 weeks).

If I had to do it again, I would go for the 12 weekly Taxol regimen (it wasn't offered to me) -- but since it will be 8 more IVs compared to DDx4, it would help to have a port (I didn't).

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: JulieKCA2013
Date Posted: Jul 18 2013 at 3:58am

Lee I have read a similar post from you about the total taxol administered. I believe some oncologists may be compensating when giving ddTaxol x 4. my last visit I checked my dosage, it was 220mg/mL squared. If all of mine were the same I would have received 880 mg/mL squared. I did not have a chance to talk to my doctor to confirm. Bottom line talk to your doctor about the dosage. I know I talked to her about 12 vs 4 treatments and she was positive they were the same. She gave me the option since side effects were lower with 12.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: Lee21
Date Posted: Jul 18 2013 at 10:04am

The standard unit for dosing is xx/m2. m2 refers to body surface area (square meters) which can be calculated from one's height and weight. When you wrote 220 mg/mL squared, I assume you mean 220 mg/m2?? mg/ml is a unit for concentration.

As far as I know, the standard DD Taxol or Taxol q3wk is given at 175 mg/m2, so for 4 cycles the total dose is 700 mg/m2. For weekly Taxol, the dose is 80 mg/m2, for 12 cycles the total dose is 960 mg/m2. These are the doses used in clinical trials comparing scheduling. For someone who is 5'4" and 110 lb (my stats), my body surface area calculates to 1.5 m2, hence the dose that was administered to me was 175x1.5 = 262 mg.

I guess it is possible that individual oncologists are adjusting the dosages on their own, but that would seem odd to me, since side effects such as neuropathy and hematological issues will increase with increasing dose. Is it possible your oncologist is referring to survival benefit and not the actual dose administered? It would be helpful if you check in with your oncologist the next time you see her to clear things up for us.

Congrats in having surgery over with and good luck with your recovery. Will you be getting radiation?

-------------
12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30
11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm

Posted By: Lillie
Date Posted: Jul 18 2013 at 11:52am

Hello All,

In 2006 I was given DD x 4 Taxol/gemzar.... I have no idea what my doseage was. I do know that after I had my treatments I began to read about the taxol weekly x 12. My understanding then was that the overall side effects were less with the lower dose weekly treatments.

That was 7 years ago and I really don't have any information to support 'one way or the other'.....

Dear Hopeful,

I have a felling that you will do well which ever regimen you choose. My prayers go with you as your journey progresses.

Love and God Bless,

Lillie

Posted By: JulieKCA2013
Date Posted: Jul 18 2013 at 5:06pm

Oops, I am use to writing that from my research days. :) I will talk to her, I haven't seen her since I was administered my last taxol. I will have a consult with radiation 2 mondays from now when the tumor board meets.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: fireagate
Date Posted: Jul 24 2013 at 10:41pm

Hi. I started Taxol today. I am in a trial called I-Spy2 and because of this I start with 12 weekly Taxol injections plus a test medication by pill. Next will be A/C , surgery then radiation.

Today I think I received a steroid, Benadryl and a anti - nausea medication (all in pill form). I wish I had written it down. I was given a prescription for Prilosec to take one a day and also a prescription for Zofran. The nurse said she recommended taking the anti-nausea medication for the first two days even if I didn't feel nauseous.

I felt tired from the moment I left the cancer center but I had been there for 7 hours. I went out for a 30 min walk and I still feel tired lol. The nurse mentioned that I would feel really hyped up due to the steroid and would have trouble going to sleep. Wondering what happened to the steroid kick, but could be due to the trial medication.

My hands also feel hot. That started not long after I left the center. It's not bad. Just uncomfortable. It feels good to hold onto a baggie with cold water in it. I hope this doesn't indicate I might have more severe issues with neuropathy?? I am taking L-glutamine as recommended by a naturopathic oncologist. I started that a few days ago. The medical oncologist discussed taking it with me today and recommended a higher dose. (10g - 3 times a day). I asked two different nurses about icing hands and feet. They both said they used it for Taxotere and not Taxol. They also said the company that makes Taxol didn't recommend it either. They felt like L-glutamine would be enough.

Has anyone else had issues with hands feeling hot? Thank you!

Posted By: tracyinva
Date Posted: Jul 24 2013 at 11:17pm

Hi there,

I just got done with the AC (thank goodness). My first taxol is next Friday. I am curious how your taxol experience goes. I have to take the 10 blue pills before my first treatment. I can give you one bit of advice that if you have bone which I had major bone pain from AC even with the neulasta shot get some Wheat Grass from the vitamin store. Its all organic and it lessened my bone pain by 30 percent at least just from the first little packet. This time last week I would have been flat on my back. I no longer require as much pain pills and can function normally for the most part. It helps to build RBC's and WBC's faster. You can research it on the net if you want. I wonder why they gave you Taxol first? I am always curious at different patients protocols. Mine is 4 and 4 AC then Taxol. I guess that is the standard I think? Anyways, Please keep me and us posted I am curious but I know neuropathy does happen in some and to tell your dr if you can't do normal things like tie your shoes other than that I would just hold and hope it passes. I asked like a dummy about the ice trick also and they gave me weirdo look. I actually feel good and will probably go back to swimming tomorrow now that my bone pain has gone down so much. I am not saying it will work for everyone but it worth a try. GL and I'll let me us know how you are doing.

-------------
Diagnosed 4/29
Lymph nodes clear on MRI on 5/20
2x2 statge 1 or 11A
AC and T 6/9 - 9/13
final mri- no lymph 4mm or less residual
Lump right side on 10/16
7 nodes taken - all clear - clean margins

Posted By: fireagate
Date Posted: Jul 25 2013 at 11:25am

Congrats Tracy on being done with AC!!! I didn't get any blue pills. What is that? They are doing Taxol first due to the clinical trial meds. I take the meds with Taxol and they want to see how that effects the tumor before any changes from AC. The oncologist said it didn't really matter which you did first. Although you are right AC then Taxol seems the standard.

I know it has only been one day from start but so far so good. My hands do not feel hot today. Had to sleep sitting up last night due to some nausea with indigestion but none this morning with breakfast. I know things could get worse but I am going to enjoy all the good feeling days I get lol.

I have read that the ice packs are good for Taxol also. Next week I am going to ask for them anyway. I'd like to see if my hands don't get hot next time, assuming I don't get more neuropathy before then.

Thanks for the wheat grass suggestion. And yea for getting to swim! Would also like to know how you are doing and how Taxol goes. :-)

Chris

Posted By: tracyinva
Date Posted: Jul 25 2013 at 11:49am

I have to try the ice packs. My nurses at the onc office are not the nicest... Well some are ..a few but the main one is a really not the nicest.

I have to take 5 12 hours before then 5 more 6 hours before which means getting up at 4 a.m every chemo until the end.

Tell how your bone pain is after Taxol? I heard its worse on Taxol than AC which scares me even more.

I like to take baths a lot so i wonder if i am going to get real hot in the tub one day from the neuro.

Funny thing is that when I got to AC the only real side effect I had was the bone pain. No nausea, mouth sores,etc... Do you have any of that on Taxol?

I juice a lot also.. I eat a lot of greens with my juicer. It's odd how everyone is really different:)

I get my chemo next Friday which will be cycle 5 out of 8 and I"ll b sure to post when I'm done. They said I will be there a lot longer to monitor the side effects so I am guessing 4 -5 hours when I am usually done in 3 when I was on AC. I loaded with Anti Nausea on AC.

Do you still get the steroid shot on Taxol ? I hate that the worst also.

Posted By: fireagate
Date Posted: Jul 25 2013 at 11:22pm

Tracy - What are the blue pills you have to take before. That isn't something I need to take, so just curious what they are for.

I did not get a steroid shot. It was in a pill form. So guess that was nice.

I make smoothies and add juiced collard greens to it lol. Otherwise eat lots of chopped up kale and swiss chard in salads.

I was also given a prescription for Prilosec to be taken daily. I asked if I could just take tums instead for indigestion and Prilosec if it got worse. Wondering if this is a normal presription given with Taxol?

The normal routine for me will be blood draw, wait one hour. Nurse checks my blood stats. Gives me the premeds. They order the Taxol (this took 30 mins) and then one hour to inject. I was then free to go.

Posted By: JulieKCA2013
Date Posted: Jul 25 2013 at 11:48pm

Fireagate, I took Prilosec and Zantac daily while on both AC and Taxol. I did find with Taxol my stomach was more sensitive. I often would get bad hiccups with Taxol, I am one month post taxol today and still get them occasionally.

-------------
Dx 3-7-13 TNBC, 5cm pT2N1M0
3-19-13 ACx4, 5-14-13 Taxolx4
7-17-13 BMX ypT1N2M0(.9mm) 4/24 nodes.
10-8-13 completed Rads x 30
12-3-13 completed Eribulin Trial
10-18-13, 3-19-14 Bone/Ct Scan Clear

Posted By: tracyinva
Date Posted: Jul 26 2013 at 12:26am

The meds I have prior to chemo to get me through my treatments 4dd AC and 4DD Taxol are below:

Hydrodcone for pain7.5/300 with actimenophen - pain as needed

decadron (for Taxol) 5 tablets 12 hours before and 5 more 6 hours before (For Taxol) I read its a steriod. (great more steroids) maybe that will replace the iv infusion I get and just take the pills.Iff I have to take steriod at 5 a.m. I will never sleep! Cry

ativan 1mg for sleep and anxiety as needed

compizine for anti nausea - 1 every 6 hours as needed

I still have to get the neaulasta shot the following day.

The steriod shot is always the worse for me. Then the bone pain. I am try to save my pain pills for when I really need them since i think i have been taking them more than a should. I got 1 refill left.

I make smoothies and load it with green stuff and bluberries and take miralax everyday to help with constipation. I know I need to drink more but I have never been a big drink. I am going work on that harder.

So that's a list of my meds. I hope that helps. I deal with the neuropathy and see if I can take any supplements at my next blood draw next wed (2 days before my taxol) They give me the results in 5 min then I meet with the rn to go over the numbers.

They said they will do the taxol really slow this time to watch for any adverse side effects. I expect to be there about 4-5 hours. The AC was about 3 or less easily.

Posted By: fireagate
Date Posted: Jul 28 2013 at 9:52pm

Thanks for the info on Prilosec Julie. Sorry your stomach was so sensitive. And I hate getting the hiccups!

Tracy just letting you know how Taxol side effects have progressed for me....2nd day definite constipation issues. :-( I took extra magnesium as recommended by my naturopath. It cleared up today. Starting 2nd day had lots of shooting type pains in abdomen and pelvic area. It progressed to thighs and upper legs. Seemed muscle not bone. Today they have mostly faded. I didn't take any pain meds but I sure hope with the next round of taxol that they don't get worse. Fatigue comes and goes and I have to be careful not to overdo it. When it hits I feel so exhausted. It is sad to say but the hardest part of it for me is asking my husband to help more.

Posted By: tracyinva
Date Posted: Jul 31 2013 at 4:25pm

Well just got back from my pre chemo blood draws. After being sick all weekend my WBC was 3.6 which was good considering how horrible I felt. For some reason I am not getting the neulasta shot on Sat to boost my WBC. I am thinking Taxol is easier on your boy and it stabilizes your counts more they are going try without to see if my body can hold its own which is scary on it's on. No eventful things. Onto chemo 5 out of 8 on Friday.They will run a very slow drip and I'll be there for almost 5 hours for any reactions. I hope it goes well. I think at chemo 6 I'll start to perk up more and see the light at the end of this long road ahead.

Has anyone else not had the neulasta after the DD Taxol? If so, how did they do?

Posted By: katiedidit
Date Posted: Jul 31 2013 at 4:47pm

I am not getting Neulasta for my Taxol treatments. The Taxol was delayed for a week after my fourth A-C treatment because my blood counts crashed severely, and I was an in-patient for four days. That was an experience. But as the WBC were recovering, the team said I did not need Neulasta. I had the first Taxol (No 5 of the 8 DD A-C/T) on July 12 and did ok. The heavy dose of IV Benedryl put me to sleep, but I did well otherwise. I had the second Taxol on July 26. I had vomiting and diarrhea on Sunday and Wednesday (today) and called the cancer center. They said to take Compazine for anti-nausea and Immodium for the diarrhea. WBC low, but nothing like with the A-C treatments. Some tingling in feet.

Good luck with your Taxol treatments.

Posted By: fireagate
Date Posted: Jul 31 2013 at 5:26pm

I am waiting for a call to see if I will be starting Neulasta. I had my 2nd Taxol treatment today and my white blood cell count went from 4.6?? to 1.27. :-( I also lost 3 lbs this past week. They were a bit concerned about that as I am already pretty thin. So I think I am doing something wrong. Going to add in more salmon and protein powder and just eat more. I just get full so easy.

They did cut my steroid down by over half what it was and took out the benydril. No allergic reaction to taxol so guess that is good.

Wondering what some typical low numbers have been for you guys? Seems like below 1 is really not good and above three good?

Posted By: tracyinva
Date Posted: Jul 31 2013 at 7:40pm

whats the purpose of stopping neulasta? My onc did not explain it to me. MY WBC today was 3.6 going into Friday for the first Taxol.Now I am worried its really going to put a burden on my system. I hop you improve fire. My dr assure me my fingernails would not fall out. She said just take my blue pills when I waked up and not right on time. So I am supposed to be taking them at 4:30. I'll take them at 9 a.m. when I get up. Weird.

Do the dr's think your body can handle the stress of taxol since it being easier on your system so they cut out neulasta ? is that the reasoning?