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123Donna View Drop Down
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Joined: Aug 24 2009
Location: St. Louis, MO
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    Posted: Jun 21 2016 at 6:20pm
Low doses of Paclitaxel (Taxol) drug may promote cancer spread

New research indicates that paclitaxel, which is the most commonly used chemotherapy for breast cancer, suppresses tumors when given at a certain dosage, but at low doses, it actually promotes cancer spread to the liver.

The findings suggest that lowering the dose of paclitaxel to reduce toxic side-effects is not a safe strategy.

"Paclitaxel and its analogous compounds are the first line agents widely used in clinical cancer chemotherapy. However, potential risks and reasonable treatment strategies of paclitaxel continue to be widely investigated," wrote the authors of The FEBS Journal study.

Article: Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model, Qi Li, Zhuang Ma, Yinhua Liu, Xiaoxi Kan, Changjun Wang, Bingnan Su, Yuchen Li, Yingmei Zhang, Pingzhang Wang, Yang Luo, Daxiang Na, Lanlan Wang, Guoying Zhang, Xiaoxin Zhu, Lu Wang, The FEBS Journal, doi: 10.1111/febs.13767, published 16 June 2016.

http://www.medicalnewstoday.com/releases/311122.php



Edited by 123Donna - Jun 22 2016 at 7:42am
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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Kellyless View Drop Down
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Joined: Jun 18 2009
Location: Dallas, Texas
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Points: 1154 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Kellyless Quote  Post ReplyReply Direct Link To This Post Posted: Jun 22 2016 at 12:55am
Well YAY for my mega dose dense super toxic taxol treatments as close together as can be done without being lethal!
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
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