No chemo

down with you and try to explain the pros and cons and then keep your fingers crossed that you pick the right one.

I have helped several young women in their 30's like my daughter was, and they had almost identical presentations when first diagnosed with TNBC and half of them had great results and half did not. They all had the same treatment. Why the difference? In 2004 we did not know about molecular testing...Maybe that was it?...They all had TNBC and all were BRCA1 positive, but different alleles...Maybe that was it? So many women with TNBC, including my daughter, have told me how they hated Taxol, and others have told me of the tough times the had with AC. And some women go flying through chemo and others like my daughter suffered through it. And some found XRT to be awful and some did fine. And some hated both ACT and XRT and others did fine.

It seems we all have our own particular set of experiences..

There would have to be a randomized trial with women who have your particular set of circumstances and 1/2 would get chemo and 1/2 radiation therapy. Don't think that trial would accrue very easily.

Sorry, I can't be more helpful. Please try to find the professionals I mentioned above and see what they say. You may have to get second or even third opinions. As the statisticians say the n is important and we all are a n of 1. Even if there was a trial like I suggested and the odds were in favor of chemo, despite your personal issues, it still might not be the best thing for you. Again, sorry to be so unhelpful.  

One more thought..there is a fairly new profession out there called cardio-oncology so maybe add that professional to the list above and between the three of them you can make as knowledgeable a decision as possible. I have seen a lot of TNBC women with heart issues over the years. It's a difficult problem.

with my love to all here,

Steve