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New blood test for cancer

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mainsailset View Drop Down
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    Posted: Jan 03 2011 at 9:42am
This is actually pretty big news as it can be used not just for initial dx but also to test if a chemo is working on existing tumors.   http://www.msnbc.msn.com/id/40881967/ns/health-cancer/
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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sue View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote sue Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 10:12am
Thanks so much for this, Mainsailset!  It made me very emotional in a positive way just thinking of the possibilities.  As I go through my chemo I constantly wonder if it is working since it is adjuvent and not neoadjuvent.  

You made my day! 

With love and hugs, 

Sue  Big smile
Dx 7/10, age 53. TNBC left breast, stage I, grade 3, IDC 0.5 cm, DCI 2.5 cm, 0/8 lymph nodes neg. BRCA-. T/C x4 finished 2/09/11, rads x34 finished 4/21/11.          
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LRM216 Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 10:19am

Wow!  Sure wish it was being used now.  Thanks, Mainy - and Happy New Year, hope it's a healthy and happy one for you.

Linda - diagnosed at age 62
Diag 2/23/09 IDC 1.2 cent. IDC right breast,Stage 1, Grade 3,0/1 nodes - Triple Neg
4 DD AC every two weeks, 1 Dd Taxol, then 3 Taxotere every three weeks - rads x 33
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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 10:23am
Thanks Mainy,

sure hope it works..

all the best,

Steve
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 1:59pm
Just curious how long will it take to be a generally available test?   We need tests like these now!

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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mainsailset View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 6:47pm
Donna, I have read that it is on a fast track for commercial/our use which should translate into 2011...
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MrsLyons Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 7:06pm
amazing!! I hope they are available soon!!
DX IDC TNBC 11/10 age 32, Stage 3a, Grade 3, 3.5 cm, 1/9 nodes, Right, KI-67 91%, BRCA-1, ACx4 (12/13/10) followed by TXx12, BMX w/expanders (6/1/2011), Rads begin 7/11/11
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Post Options Post Options   Thanks (0) Thanks(0)   Quote tninalabama Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 7:09pm
It sounds promising! We can only hope it comes out soon!
Dx 11/07,stII bgr3,1/8+, metaplastic, recurrence 11/09, lymph dis 12/13+ 07/10, rad,x28 9/10,02/11 mets

BRCA neg
5-FMC since 03/12
PET 04/12,no progression
Bone scan clear 06/12
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Post Options Post Options   Thanks (0) Thanks(0)   Quote TNBC_in_NS Quote  Post ReplyReply Direct Link To This Post Posted: Jan 03 2011 at 7:58pm
Mainy:
Please let this be the smokin gun we have been waiting for!  If we find the cells still there after our tx, then what? What meds are here for us? TN BRCA neg, etc....? Great to know, but would be better to have chemo to go with it.... Hugs, h.
Diag@57TNBC04/092.5cm Lquad 05/09 TCx4Radsx30CT03/01/10 FU03/31/10ClearBRCA- 01/2011 RTNBC BMX 06/14/2011~2013 clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Pink Warrior Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 1:17am
Amazing!!  Something to jot down and talk to the onc about!  

See if he knows anything regarding time frame.  Absolutely outstanding.
Dx:10/09,IDC Stg 2,Gr 3,TN
BRCA 1&2 -
Partial DD EC/AC
Local recur 11/10
BMX 12/10 Right proph
TC x 4 Rads x 33
9/11 Skin mets, mediastinal & hilar nodes
Abraxane/Avastin
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 9:11am
Helen, Connie had mentioned to me that it has been in the works, and I believe I've seen some women here mention it, to continue with a chemo for up to a year after the original treatment has been completed (chemo, mast, radiation). This would certainly make sense for a TN and though it would be hard on us ladies, just might clean house on any remaining cells.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LRM216 Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 9:23am
According to my onc, Mainy - that's exactly the problem.  I asked about residual chemo after treatment, and while she understands my logic of wanting it, she said it's not done when all original treatment ends as it would wipe us out entirely.  As she said, it is still a poison, and even to give a diluted maintenance type formula (which of course has no scientific backing at this point in time, so they'd not even consider it unless you in fact needed further treatment), would be too injurious to all the normal cells and your organs.
 
Perhaps someday they may have something such as a maintenance type "mop" - cause it sure makes sense to me.
Linda - diagnosed at age 62
Diag 2/23/09 IDC 1.2 cent. IDC right breast,Stage 1, Grade 3,0/1 nodes - Triple Neg
4 DD AC every two weeks, 1 Dd Taxol, then 3 Taxotere every three weeks - rads x 33
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 1:04pm
Linda, well said. Reading your post I suddenly thought that with TN I've always referred to it as the Ebola (the deadly African virus) of bc as I consider TN "Hot" and that's why chemo works so well. We have an aggressive, hungry cancer that therefore needs nutrition and so when we apply a chemo which starves it, we see better results than the slower growing bc's.
 
That said, logic tells me that continuing chemo for ...  say a month after last radiation would likely kill off the residuals because they grow so fast while not cause irreparable harm to us so maybe it's not just the diluting but a question of timing...could that be workable? Anyway, just thinking out loud on my keyboard.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LRM216 Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 1:31pm
I hear you, Mainy!  and yes, yes, yes, now that you mention timing - she also said something about that - that there had to be a point in the cell's splitting cycle to administer the chemo, and with no known cancer active and splitting, this could not be achieved and would therefor just be poisoning our organs and killing of good necessary cells (or to that effect).   I must ask her again, next time I see her.
Linda - diagnosed at age 62
Diag 2/23/09 IDC 1.2 cent. IDC right breast,Stage 1, Grade 3,0/1 nodes - Triple Neg
4 DD AC every two weeks, 1 Dd Taxol, then 3 Taxotere every three weeks - rads x 33
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Pink Warrior Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 1:56pm
I'll ask my onc as well.
Dx:10/09,IDC Stg 2,Gr 3,TN
BRCA 1&2 -
Partial DD EC/AC
Local recur 11/10
BMX 12/10 Right proph
TC x 4 Rads x 33
9/11 Skin mets, mediastinal & hilar nodes
Abraxane/Avastin
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Post Options Post Options   Thanks (0) Thanks(0)   Quote kaycee Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 2:15pm
I saw this clip on my local (Kansas City) news last night. Apparently much of the work on this new test is being done at University of Kansas Med Center.

http://www.kmbc.com/video/26362551/detail.html

According to this story, the test HAS been approved for the following types of cancer:

  1. Breast
  2. Colo-rectal
  3. Prostate

They are still working on FDA approval for lung, kidney, head and neck, melanoma and other cancers.

I'm really excited about this test and excited to hear that KU Med is close to gaining NCI status! That will be wonderful for our community.



DX age 54, lumpectomy, IDC,10mm, 0/10 nodes, Stage 1 Grade 2, ER-/PR-/HER2neu-, Ki-67 74%, BRCA negative, TCx4, 6 weeks rads
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LRM216 Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 3:43pm
Linda - diagnosed at age 62
Diag 2/23/09 IDC 1.2 cent. IDC right breast,Stage 1, Grade 3,0/1 nodes - Triple Neg
4 DD AC every two weeks, 1 Dd Taxol, then 3 Taxotere every three weeks - rads x 33
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 4:07pm
Interesting correction. I have also found that this test initially was researched back in 2004 and did well then so it has already passed various layers of research with good outcomes.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Cathy Leigh Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 4:11pm
Mainy, I hope this happens fast!!!
 
Donna, I love your new picture
 
Happy New Year to everyone
 
Cathy
61 years old at dx 12/1/09
Left Mastectomy 2/4/10, 2 sentinel nodes negative and margins around tumor negative
Clean PET/CT scan on 3/2/10
ac/taxol began 4/2011-Finished 9/10. CT Scan 8/11 NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jan 04 2011 at 5:04pm
Quote:  "Four cancer centers will do tests this year using that new design with a grant from the Stand Up to Cancer telethon. Johnson & Johnson has joined with Mass General to develop a third-generation test with a different technology aimed at mass production."

I wish we could get a timeline on the mass production test.


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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