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Loricarol 
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Joined: May 24 2009 Location: Utah Status: Offline Points: 85 |
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 Topic: Metaplastic?Posted: May 28 2009 at 11:05am |
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Hi ladies
After reading my path report myself i was alalmed to see the words metaplastic features and squamous cell differentation. Does anyone know what metaplastic means?
Thanks !
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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trip2
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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Posted: May 28 2009 at 12:52pm |
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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Loricarol
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Joined: May 24 2009 Location: Utah Status: Offline Points: 85 |
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Posted: May 28 2009 at 1:50pm |
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Pam
Thank you for the information. My ONC stated that having some metaplastic components to my tumor did not mean that i had metaplastic breast cancer. I hope she is right. Then she asked if i wanted a third opinion. Sometimes i feel likethe patient asking questions is a bother to them. But it is our bodies and our lives at stake.
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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trip2
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Posted: May 28 2009 at 2:33pm |
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Hi Loricarol, you are so right!!
It is our bodies and we are hiring these people to make us well.
That was interesting information about how your tumor may just have some metaplastic components. This really gets confused doesn't it??
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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glenine
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Posted: May 28 2009 at 3:02pm |
Hi!,
I was dx back in 2001 with metaplastic carcinoma with met to the lung.
This type has components of both a sarcoma and a carcinoma...It is rather rare also..I sought out a third opinion at St Vincents in NY with Peter Paul Rosen MD a leading sarcoma expert.His advice is to have the actual slides looked at by a few pathologists in a leading cancer center. Interesting also that this type usally spreads via the bloodstream not the lymph nodes/My nodes were neg but the cancer went to the lung via trhe blood.
take care,
glenine
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Loricarol
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Joined: May 24 2009 Location: Utah Status: Offline Points: 85 |
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Posted: May 28 2009 at 3:15pm |
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Glenine
I cant even seem to get a straight answer from Huntsman on the path report. They say that the fact that the pathologist states it has metaplastic components means "nothing". I'm not comfortable with that answer but when i ask questions its as if i have insulted theri intelligence or something. How did you get a third opinion while you were in Chemo werent you too tired? I want a third opinion too but now wander with chemo looming if i will have the strength to do it. And if i get the opinion and it is metaplastic will it change my course of treatment?
Glenine how are you doing since 2001? It looks like you have done well even with lung mets.
I guess i need to get my slides and all my chart together then and seek out that third opinion.
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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trip2
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Posted: May 28 2009 at 4:51pm |
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Loricarol, so you have already had a second opinion?
There is certainly nothing wrong with a third opinion. This is your body and you want to do the best they have to offer to you.
Maybe you could get in to see someone before chemo begins?
Good luck to you and let us know if we can help.
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Loricarol
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Posted: May 28 2009 at 5:32pm |
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Pam
I have had 2 opinions but neither commented on what i read in my own pathology report about having metaplastic components in part of one of my two tumors. when i questioned my current MD at Huntsman here in Utah she brushed it off and said its just a different type of cell they see on the pathology. It was as if she knew nothing of metaplastic breast CA or didnt care to discuss it with me. She indicated that it made "no difference"in my care at all. No one had ever told me that the patholgy said one tumor had "metaplastic components characterized by squamous differentiation with enlarged ,bizarre nuclei and numerous highly atypical mitotic features. This is scary stuff yet none of them ever even told me it was in my report. What do you think? Im a nurse so im pretty aware of what most of those medical terms mean.
I hope to get that third opinion but also realize i must not delay chemo either.
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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ChrissieD
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Joined: Dec 30 2008 Location: United States Status: Offline Points: 131 |
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Posted: May 28 2009 at 5:32pm |
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Loricarol,
You asked a good question about whether or not it would be treated differently if it was metaplastic. I would get a 3rd (or 4th or 5th...) opinon if you don't feel you have all the answers you need. If you don't feel up to physically to get all the slides/etc. and go to see anyone else perhaps you could email with your third opinion doc to ask the question. I emailed with my 2nd opinion doctor a couple times before I made an appointment to see him (he is a famous onc too).
Keep at it until you get the answeres you need.
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39 from MA, Mom(8.5 and 6),
Lumpectomy IDC 1.5cm Stage I, Grade 3 ACx4 Taxolx4 dose dense started 11/17; Bi-lateral Mastectomy with expanders scheduled for 3/24/09 God is carrying me through ! |
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Loricarol
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Posted: May 28 2009 at 5:41pm |
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Chrissie
wow thanks for replying. Is there any way you would share with me who your ONC is? maybe he would do the same with me? All i would need to do is get my slides and file to him. I would love to get connected with him now. Do you think he would consult with me? Im just feeling pushed for time and like the 2 ONC's here are acting as if it isnt anything to even consider not even worth discussing it. grrrr Its my life and i want to fight this cancer with the best advice and medical help out there. If you take your slides from your original hospital can they be replicated or what?
God is carrying me through too!
Thanks and God Bless
please write me back.
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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trip2
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Posted: May 28 2009 at 6:18pm |
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Loricarol,
In this ACS article, scroll down to Metaplastic and it says it is treated like an invasive ductal breast cancer.
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Stage 2 2003
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Loricarol
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Posted: May 28 2009 at 7:01pm |
 Pam
THANK YOU!! I have been looking for information all evening and trying to decifer how it would change anything if in fact my tumors were metaplastic. As it stands now with the help of your very reputable article i can rest knowing that the treatment would essentially be the same.
Thank God my path says just a "portion" of one tumor has componets so at least not the entire tumor shows these cells.
God Bless you!
Lori
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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mefowler
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Posted: May 28 2009 at 7:23pm |
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Dear Lori and others, I PM'd Suzie with this study, and she thought that I should put the link on the board. This is a study with tyrosine kinase inhibitors for metaplastic breast cancer. It is available on-line at no charge at the following web address: http://mct.aacrjournals.org/content/7/4/944.full.pdf+html Hope this is helpful to some of you.
Maire
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glenine
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Posted: May 29 2009 at 1:45am |
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Good Morning,
Your best bet is to contact MD Anderson in Texas ....Inquire about a pathology read"..........and how you would go about getting your slides to the correct department........But they will need the tumor slides.
Because of the sarcoma component in the tumor My onc went with just a high dose of Adria followed by Taxatere..
I have been disease free for 8 years at stage 4..My met was removed via a VATS proceedure at Sloan in NY...after that we went with the chemo.then I had a double mast with recon..Whew!...Third opinion I believe are the smart thing to do.In my case Two onc just wanted no tx The third said we have to treat systemically just in case..Hope this helps.
Here is the name of the Onc I used
Peter Paul RosenMD,St Vincents Hospital
New York,NY
Google him.He is brilliant...
glenine
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glenine
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Posted: May 29 2009 at 2:00am |
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Although the paragraph states it is treated like a ductal carcinoma.I would definately explore this further and rely on the experts that see this type..Remember its rare...........The study my onc followed was from an onc at MD Anderson.I relied on both their experience in treating this type.Not on a blurb from the ACS site.Just my opinion.
Cheers,glenine
p.s. I am also an RN
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Loricarol
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Posted: May 29 2009 at 3:34am |
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Glenine
I agree with you i will be seeking the thrird opinion. I will call MD Anderson about a Pathology read. Wil they return your slides? can you get copies of your slides or are they the only ones? That is awesome that you have been disease free at 8 years! Praise God! I have a neice that lives 6 blocks from Kettering. I guess i can get a path read from MD Anderson and still start my chemo here right? Im on dose dense AC folloed bt T for 12 weeks weekly. I will also look into Peter Paul Rosen. I realy appreciate your help. By the way i had found 1 year prior to me BC a 4mm nodule in my lung. It hasnt changed in a year they are saying it is a beign pulmonary nodule and its in a location where i would require open surgey to get it removed and of course facing chemo cannot attempt that. But i have been wandering about that nodule but with 2 CT's over 8 months it has not changed at all in size just 4 mm. What do you think? If it were cancer it should have changed in size in 8 moths right? My breat tumors grew in 5 months! Great to talk to another RN! Your an inspiration.
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DX 4/30/2009 IDC, stage 1 ,grade 3,2 tumors,node negative,clear margins ,BRCA negative left breast mastetcomy, 4 cycles of Adramycin and Cytoxan 12 weekly treatments of Taxol start 8/12. No rads.
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glenine
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Posted: May 29 2009 at 4:06am |
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Your slides could also be done at Sloan.Call them too.Asfar as the nodule.Did you have a pet scan?........this will be a good diagnostic tool to see if that lung bugger is a met.But I highlt doubt it.No change in size is good!......Cytoxin was not for me due to its lack of effectivenss on my type of tumor...I did have taxatere though..Good Luck and never stop asking questions..Don't settle for anything.........
glenine
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glenine
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Posted: May 29 2009 at 8:07am |
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Hey sweetie,
If you would like call Michael Spirtos MD.Duke Medical Center in North Carolina
Ask to speak to him personally.Tell him you were referred to him by
glenine gregory.
Maybe he can give you the how and where of what you need to do
P.s. He is an old beau from High School!
Very Wonderful Man
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trip2
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Posted: May 29 2009 at 9:37am |
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Loricarol,
Here is another link http://www.dslrf.org/breastcancer/content.asp?CATID=68&L2=3&L3=7&L4=0&PID=&sid=132&cid=1316
This link also says metaplastic is treated like any invasive ductal breast cancer.
I consider my "blurbs" to be coming from very reliable sources.
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glenine
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Posted: May 29 2009 at 12:20pm |
With limited research done Metaplasti carcinoma, they had to tuck it somewhere............
I never called your google reference a blurb either.
glenine gregory-Ryan RN MSN
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