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How white blood cell promotes tumor growth

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123Donna View Drop Down
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    Posted: Aug 31 2011 at 9:02pm

Research scientists reveal how white blood cell promotes growth

Scientists at The Scripps Research Institute have shown that a particular white blood cell plays a direct role in the development and spread of cancerous tumors. Their work sheds new light on the development of the disease and points toward novel strategies for treating early-stage cancers.

The study was published in September 2011 print issue of the American Journal of Pathology.

Scripps Research Professor James Quigley, Staff Scientist Elena Deryugina, and colleagues had previously demonstrated that white blood cells known as neutrophilsA—bone marrow-derived cells that function as “first responders” at sites of acute inflammationA—promote the growth of new blood vessels in normal, healthy tissue.

The team has now tied these cells to the induction and growth of new blood vessels in malignant tumors and to the spread of tumor cells through those newly formed vessels. The scientists have also uncovered some of the mechanisms underpinning this processA—which could be interrupted by properly targeted drugs.

. . . .

Intriguing Possibilities

The scientists note that the study suggests tumors that engender a strong inflammatory response may be particularly amenable to early-stage treatment by drugs that specifically target neutrophils, whether that means inhibiting the enzyme they deliver or simply preventing them from showing up in the first place.

“It might be best to combat tumor angiogenesis earlier rather than later,” Quigley said, adding that “more specifically directed anti-neutrophil agents might be better suited than a general anti-inflammatory.”

To read the entire article:

http://www.breakthroughdigest.com/medical-news/research-scientists-reveal-how-white-blood-cell-promotes-growth-and-spread-of-cancer/


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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mainsailset View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Aug 31 2011 at 9:21pm
Good catch Donna. Scripps seems to be doing alot of valuable research for us and yet they also seem to be flying under the radar to be noticed by most mainstream media.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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