Dear LadyDi,
I am the adult son of a TNBC patient who is in active treatment (done with neoadjuvant chemo and surgery ... now going through radiation) I am not a physician and can only note experience from our case. Mom was diagnosed at stage 1B, KI-67 = 50%
My mom was given a choice between anthracycline and non-anthracycline courses of therapy. She chose the anthracycline course (DD AC-T) In her early seventies, evaluation of heart condition was a significant step. Since her chemo came prior to surgery, she could physically feel the tumor shrinking and eventually dissolving primarily while on the anthracycline based portion. Although not diagnostic - it was encouraging to her. Then after the taxane course and surgery, PCR was noted in her case so that is exciting.
Only time will tell if cardiotoxicities from the anthracycline portion were worth the risk. So far there have been welcome results regarding treatment of the cancer.
I would guess your MO will take into acount your KI-67 % and other proliferation risk factors. Retrospective studies are remarkably useful but it is tough for them to isolate all variables.
Respect to you and best wishes for your upcoming decisions.
Kind Regards,
Gerald