What do you think?? |
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trip2 
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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 Topic: What do you think??Posted: Jun 06 2007 at 2:38am |
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CalGal
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Joined: Jun 04 2007 Location: United States Status: Offline Points: 159 |
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Posted: Jun 06 2007 at 12:16pm |
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Hi Trip2 -
Interesting ... but us trip negs, need the chemo options. Reading similar stat's in Dr. Love's book (that the majority of women do not respond to chemo) and having a clear SNB and wanting kids, I passed on chemo on my initial dx in fall 2004 ... and then had a recurr and mets 15 months later. Fortunately, I responded great to AC, my breast tumor disappeared after 3x and my liver mets shrunk. I ultimately did 6 dose dense AC. I think the article should give more info on Topoll-2, since it states that the 8% of women with that gene respond to the therapy being discussed. I googled Topoll-2, but most of what came up was in a different language. As of this year, I'm being treated at UCLA, but I don't see Dr. Slamon. What are your thoughts? CalGal |
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BRCA1
9/04 Bi-lat lump, clear SNB 38x Rad'tn 12/05 Recurr bc & mets to liver 06 the year of chemo NED for 13 mos until 7/07 Lung met. PARP trial until ... 2/08 Liver mets again |
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trip2
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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Posted: Jun 08 2007 at 5:11am |
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CalGal, well I am confused about this article, at first I found it very disturbing, look at all the people who have been given A???
Another interesting thought for me is that when I read other's opinions on this it gets interpreted a little differently so maybe I'm not seeing something others are seeing. Were you triple neg both times and w/your mets? I need to re-read the report I guess.
Oh I know we are given the best at the time, we do what we are advised and hopefully do a little research and A seemed to be a good one.
I know not every chemo works for everyone but those percentages are so big if 92% are not being helped.
Also if I understand correctly most of us are given other chemos along w/the A so hopefully those work.
I know mine came back but who can say it is because of A? Not a soul.
I'm going to get my Love book back out and do some reading.
The topoll-2, I agree, we need to learn more about this.
I've read your story before and it has just sunk in w/me that you did not do chemo the first time. I'm so sorry that it came back but whoohoo,
it worked! You were in that 8%, NED, that is fabulous,
If I sound out of it I'm sorry, having a hard time w/this taxotere.
Pam
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momtopebbles
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Joined: Jun 22 2007 Location: United States Status: Offline Points: 13 |
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Posted: Jun 22 2007 at 2:15pm |
 I sure hope it was effective on mine. I took four rounds of AC as insurance. I had no pos nodes at my tumor was only 9mm. I passed on the taxol because it would only give me a 2% better chance of non-reoccurance and it can cause nerve damage in the hands & feet and i already have arthritis in those. My onc was in total agreement and said most onc's don't even offer it form stage one node neg, but he leaves it up to the patient. They are learning so much all the time so (God forbid) if I ever have to fight the beast again there will be new weapons to fight with
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trip2
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Posted: Jun 23 2007 at 8:07am |
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Yes, they are learning all the time and coming up with new weapons to fight with so that is the good news.
So many women have had AC and they are fine, I hope you won't worry about this.
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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JaneRA
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Joined: Jun 03 2007 Location: Great Britain Status: Offline Points: 24 |
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Posted: Jul 16 2007 at 2:25am |
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Interesting article.
I had 6 AC at primary diagnosis neo adjuvant. Lump appearred to shrink prior to surgery but then grew again and I still had active cancer in breast plus 23 nodes with cancer at surgery. So AC useless. Then had 4 taxotere after surgery. Renmssion after treatment of 2.5 years till regional (Stage 4) recurrence April 2007.
I think chemotherapy generally is less effective than we like to kid ourselves...but in the absence of other treatments what else can we do? I am not inclined towards any alternative tretaments so just take the conventional stuff...always knowing its probably not going to save my life..but might prolong it a bit.
Currently on navelbine and xeloda for regional recurrence....
One day in the middle of this century people will look back at all this toxic chemo we endured and wonder at the folly.
Jane
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Jane
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trip2
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Posted: Jul 16 2007 at 3:47am |
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Hi Jane, how are you doing? It's good to see you posting. You are right, what else can we do but chemo does help alot of women and thank heavens they are coming up w/more for us to try. It is all we have right now. I'm too a bit weary of alternative treatments. I know there is alot more to be done but when I look back at when my family had c in the 70's and earlier they didn't even have the options that we have and they went thru some terrible treatments.
Just in the last 4 yrs since my first diagnosis I have seen a pretty good change in more chemo choice, side effect meds, things like that that can make a big difference while going thru chemo.
Hugs to you
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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mckell1234
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Joined: Jul 09 2007 Location: United States Status: Offline Points: 31 |
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Posted: Jul 16 2007 at 5:57am |
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I can say that I'm glad I got the A anthracycline. Who knows, we are already in the lower percentage in being triple negative, maybe the 8% it does benefit with the Topol is us. (Positive thinking anyway). I'll try to find an article I saw the other day where it also states that Herceptin may benefit triple negative, did any of you see that one?
Heather
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JaneRA
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Posted: Jul 16 2007 at 7:23am |
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Herceptin and triple negative????
Can't quite believe that one as we are negative for her2?? So if there is such an article would be very interested indeed.
Jane
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Jane
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PineHouse
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Posted: Jul 17 2007 at 3:34pm |
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I think I've seen some articles suggesting that Herceptin may help other "overexpression" such as HER1, not just HER2. And if I'm not mistaken, people say that triple negative tumors are not just triple "negative", they must be positive for something that we don't know yet, and it's possible that some triple negatives may be positive for HER1 overexpression.
Am I making sense? Sorry I don't have the particular article(s) handy.
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Stage IV lung-06/06 brain-12/08 BRCA1 TNBC
Avastin+Taxol,Carboplatin,PARP-Inhibitor,Navelbine+Xeloda,Avastin+Ixempra,Doxil+Cytoxan Currently Abraxane+Gemzar (3/09) http://pinehouse.wordpress.com/ |
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JaneRA
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Posted: Jul 17 2007 at 10:51pm |
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In response to Pinehouse...
yes in the last few years there has been a lot of reserach into the growth factors which do affect triple negatives. Among them are EGRF (epidermal grwoth factor receptor), p53, nestin. I understand that there are many others and also her1, her3 and her4. Reserach into each of these growth factors could lead to a new targetted therapy for triple negative tumours but its going to be several years before anything will be avaialble in a clinical setting.
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Jane
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