Avastin & Abraxane - Anyone Else? |
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Wendy2 
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Joined: Apr 10 2008 Location: United States Status: Offline Points: 213 |
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 Posted: Sep 05 2008 at 2:00am |
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An's sister
I have terrible hip pain and am having an MRI on Monday. I just thought it was some aches from the chemo. Keep ya posted.
Wendy
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dx 3/06 TN, taxotere/cytoxin x4; radiation x 40; mets. to lungs, lymph nodes 3/08 - to begin chemo 4/29/08 Abx/Avas., 9/08 Avastin maintenance, 1/09 - off meds to see if Avastin causing headaches
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cmtrots
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Joined: Sep 04 2008 Location: Montana Status: Offline Points: 108 |
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Posted: Sep 05 2008 at 7:08am |
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another nancy,
Good to hear this regimen is working for you. Gives me hope. I feel a little better to hear that you and others experienced headaches too. Thanks |
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another nancy
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Joined: Jul 18 2008 Location: United States Status: Offline Points: 10 |
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Posted: Sep 06 2008 at 2:37am |
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Spoke to my doc about the headaches...she is planning to switch the premedicine before chemo to see if that helps. She thought the Decadron they give me before chemo may be the cause. She said if the headaches were constant, she would do an MRI to see if there is any swelling of the brain due to the avastin use.
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Original DX 1/31/08
Port - Neoadj Chemo 2/07 A/C Rt Mast 4/08 Stage 3B 4/7+ nodes 5/08 PET - subclavicular /mediastinum node+ 5/08 Chemo Abraxine/Avastin 8/08 NED More chemo and rad to follow |
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CarynRose
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Joined: Aug 04 2007 Location: Robbinsville, NJ, USA Status: Offline Points: 960 |
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Posted: Sep 06 2008 at 3:21am |
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Glad you and your doc are on top of it nancy.
Hugs,
Caryn
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Orig dx 6/03 - St.2a, IDC
gr.3,0 nodes, TNBC/BRCA1+ 7/07 St 4 mets to nodes/lungs. PACA/Rads NED 11/07-10/08 Lepto mets 10/08 Rads for 4 brain tumors 4/10. Leptomets return 6/10 |
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lilysmomac
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Joined: Sep 04 2008 Status: Offline Points: 2 |
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Posted: Sep 06 2008 at 6:55pm |
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Dear Connie,
Thanks so much for the info. Angela has been on Zometa for about a year and a half now. Do you think that she could have her dose increased? Is this a drug that her body could become tolerant to, and perhaps isn't working for her any more? Does the intensity of her pain sound like the effects of the chemo or more like the cancer? Her oncologist said that she seems very confident that it is probably just the chemo effects because she just had a clean bone scan. I fear that it could be the cancer, because the pain is just so darn bad and constant for her and nothing is seeming to ease it. We will ask both about a Fentanyl patch as well as Zeloda on Monday. Thank you so much. Ang's sis |
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CalGal
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Joined: Jun 04 2007 Location: United States Status: Offline Points: 159 |
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Posted: Sep 15 2008 at 2:22pm |
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Hello All -
It's been awhile, so here's an update. The weekly (3 on, 4th off) really keep one busy. At the last minute - DH and I decided to go to Ireland - buying our tix just 2 wks prior. I took advantage of off wk #4 and delayed starting the next round by one week. It was a wonderful trip and so great to get-away from cancer-world! The day we left, I had my PET/CT scan that morning, the first scan since adding Gemzar to the mix. After we returned, I got the results on Friday. Day 1 - Avastin, Abraxane, Gemzar Day 8 - Abraxane, Gemzar, Zometa Day 15 - Avastin, Abraxane, Gemzar Day 22 - Off! For me, adding the Gemzar really helped! All of my mets shrunk or were stable!! That's quite a few mets: lung, mutliples in the liver, abdominal node and T-7. Only the latter one stayed the same, the others shrunk! However, there is one new one in my liver, but I can't help but to wonder if it was missed due to the way the "slices" went. On the down side, the "uptake" was increased on most lesions ... Onc & I decided we'd stay on this treatment. So, back to Avastin & chemo tomorrow ... It's been so great to have a 3 wk break! CalGal |
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BRCA1
9/04 Bi-lat lump, clear SNB 38x Rad'tn 12/05 Recurr bc & mets to liver 06 the year of chemo NED for 13 mos until 7/07 Lung met. PARP trial until ... 2/08 Liver mets again |
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Nancy
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Joined: Jul 23 2007 Location: Altoona, PA Status: Offline Points: 3814 |
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Posted: Sep 15 2008 at 2:55pm |
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Hi there CalGal,
About time you checked in
 So glad that you got away. I know a few people who have been to Ireland, and they say it is beautiful. So, you got rejeuvenated!! That is wonderful news as to the scan
 The mix must be working! You will have to explain to me what you mean by the "uptake" was increased on most lesions. I know that I ask many questiona of all of you gals, but I really want to know, and who better to ask...than all of you. Thank you for being patient with me when I do ask. Now if I can just retain all this information Just keep the visual imaging of Ireland when going for treatment tomorrow!
 Hugs,
Nancy
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CalGal
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Joined: Jun 04 2007 Location: United States Status: Offline Points: 159 |
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Posted: Sep 15 2008 at 3:16pm |
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Hi Nancy -
Thanks ... The trip was just great, we rented a car and DH did a very nice job driving (on the opposite side) all over the country! I was the navigator. On a PET scan they inject a radioactive glucose type of substance that "picks-up, lights-up or uptakes" on "active areas" which are primarily growing cancer cells. So, while it was great that almost all of my lesions are shrinking, there is "increased activity" ... So I take it as the cancer cells are getting more active. Low uptake or no uptake (dead cancer cells sometimes) is much preferred! I'm relieved to be staying on the same treatment. I read thru the entire Ixempra thread here, figuring that is my likely next option ... but hopefully, I won't need it for a long time! CalGal |
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BRCA1
9/04 Bi-lat lump, clear SNB 38x Rad'tn 12/05 Recurr bc & mets to liver 06 the year of chemo NED for 13 mos until 7/07 Lung met. PARP trial until ... 2/08 Liver mets again |
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trip2
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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Posted: Sep 15 2008 at 3:24pm |
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Hi Calgal,
I am so happy for you that the Gemzar worked.
You sound like the trip did alot for you and I'm happy to see you had the opportunity. Sometimes we have to just grab onto what sounds like a fun idea, the break is needed to go for it!
Hugs,
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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thinkpositive
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Joined: Jun 24 2007 Location: United States Status: Offline Points: 111 |
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Posted: Sep 25 2008 at 12:56pm |
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I have been on Avastin and Abraxene since Feb for lung mets. Previous scans showed real improvement but Monday's scan shows progression of the mets - some spots that had shrunk are growing again. Onc. is proposing Avastin and Xeloda as next regimen.
Has anyone experienced similar recurrence ? Would also like to know what to expect with Xeloda - how often and what dosage ? Side effects?
Needless to say I am concerned that I am starting over - any suggestions about alternative treatments that I should pursue would be welcome.
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dx 3/06 stg II 0/7 lymph
bilateral mastectomy 7/06 AC/Taxol lung mets 1/08 Avastin Abraxene 02/08/9/08 Brca neg Avastin Xeloda 10/08 Curagen 2/09 Ixempra 6/09 Lung Mets Gemzar/ Carboplatin 9/09 |
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vickyann
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Joined: Sep 25 2008 Location: Texas USA Status: Offline Points: 127 |
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Posted: Sep 25 2008 at 1:11pm |
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Positive thinking and keeping yourself in the best shape ,mind and body is the key to everything. Miracles happen eveyday. How did they fiind the lung mets? vickyann
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thinkpositive
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Joined: Jun 24 2007 Location: United States Status: Offline Points: 111 |
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Posted: Sep 25 2008 at 1:28pm |
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Hi - yes trying to stay positive. They found the mets when I did my routine follow up xray. Funny thing was that I had some pain in my arm and thought I might have bone mets - I was surprised when the lung mets showed up. I had 4 spots, 3 were not visible after treatment and the 4th was smaller but the latest scan shows progession. I see the doctor on Tuesday.
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dx 3/06 stg II 0/7 lymph
bilateral mastectomy 7/06 AC/Taxol lung mets 1/08 Avastin Abraxene 02/08/9/08 Brca neg Avastin Xeloda 10/08 Curagen 2/09 Ixempra 6/09 Lung Mets Gemzar/ Carboplatin 9/09 |
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cmtrots
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Joined: Sep 04 2008 Location: Montana Status: Offline Points: 108 |
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Posted: Sep 25 2008 at 1:45pm |
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I went to one of the top research hospitals ( IU Medical, where Lance Armstrog went)and saw a Breast Cancer Onc. to get a second opinion for my lung mets. He suggested 1.Avastin and Abraxene 2. Avastin and Nalvadene 3. Avastin and Taxol. He said if no luck with those he suggested a clinic trial in Inianapolis called MPA. Never mentioned Xeloda. A couple years ago, before lung mets, just lymph node involvement I was on Xeloda. My cancer came back in a month and it really took a toll on my feet and hands. Plus bad diharrea. I don't remember the dosage or regimen, sorry. Plus eveyone tolorates these chemos differently. Don't want to scare you about Xeloda, cause people react differently to treatments too. I think I've heard on this post some successes with Xeloda. I'm on Avastin and Abraxene right now, due for my first scan in a couple of weeks. Maybe ask your doc about Avastin and Nalvadene, guess it wouldn't hurt. How many lung mets did you have? How many do you have now?
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