Dear
VGonnaMkit,
Great. AIIMS is a great hospital.
Ok on the BRCA 1, 2 Testing. If the results do show a BRCA mutation, then you can ask for Single Agent Platinum treatment post surgery and radiation. But this is something to discuss with your doctor, or by getting a 2nd Opinion.
It all depends on how your wife does on this prescribed regimen and based on the genetic testing results.
Also, just because there is no immediate family history, does not mean that you should not test for BRCA. Because you wife is young, you ought to get the testing done. You Genetic Counselor will work with yourself and your wife to create a family tree, they will do the testing, and when they deliver the results they will give you the necessary counselling associated with the results.
Additional therapy may only be necessary if your dear wife does not have a PCR (Ask your doctors to tell you what the residual disease is, if any, after all chemo is finished).
Residual Disease, if any cancer is left over after chemo, can be calculated by applying the formula in the below link:
http://www3.mdanderson.org/app/medcalc/index.cfm?pagename=jsconvert3
If there is residual disease present, then take your RCB Index Score and consult with your now doctor and an expert 2nd Opinion doctor on what you ought to do next. This will be important.
PCR stands for Pathological Complete Response (to the now prescribed chemotherapy).
RCB stands for Residual Cancer Burden.
If she has a PCR, then great. If not, then push for more treatment, or at least a good 2nd Opinion.
You will need good counselling when you take the BRCA test, as there are repercussion and guidelines for surgical decisions and also with regards to Ovarian Cancer (not just breast cancer). Therefore, doing the BRCA test before surgery is vital as it has surgical implications (and will greatly impact your personal decisions on Lumpectomy vs. Mastectomy etc).
http://www.facingourrisk.org/index.php
http://www.facingourrisk.org/understanding-brca-and-hboc/information/hereditary-cancer/genetic-testing/
(the above sites are good sites to review)
If there is no BRCA mutation, then simply consult on next steps with your doctor, as per NCCN clinical practice in Oncology guidelines.
Focus on response to current treatment guidelines for now. She could do very well on this treatment also, so it is important to think positive thoughts and hope for good. Ensure she is well taken care of, she eats well, takes lots of water before her treatments, and keep her smiling and laughing as much as you can.
Both of you look after yourselves. It is an important time to be there for her, and to also look after yourself.
Remember, it is important to take care of You also!
God bless you two.
Edited by made2b2gether - Feb 16 2016 at 3:30am