Hi, Everyone,
We're a small biotech in Cambridge MA working on treating cancers that are sensitive to metabolic hormones (like insulin). We know a few things about how these hormones, which frequently stem from overweight/obesity and T2D, impact disease progression and what kinds of things can be done to help.
I'm here to listen, learn and share what I can (I'm not an MD and will not provide medical advice) about this topic.
"...insulin resistance, dyslipidemia, and hypertension are associated with
increased incidence of breast cancer across all subtypes. The
insulin-leptin-adiponectin axis has been implicated mechanistically in
breast cancer tumorigenesis. Specifically, increased leptin and
decreased adiponectin levels disrupt homeostatic signaling pathways
involved in cell proliferation, survival, cell-cycle regulation, and
angiogenesis. Insulin, insulin-like growth factor I (IGF-I), and
epidermal growth factor receptor (EGFR) may mediate interactions between
these two hormones."
If I can answer any questions or point you in the right (hopefully) direction, I'd be happy to.