QuoteReplyTopic: New Immunotherapy Trial for Advanced TNBC Posted: Jun 29 2020 at 4:28pm
UbiVac Announces Clinical Trial Collaboration with Bristol Myers
Squibb on Combination Immunotherapy for Advanced Triple Negative Breast
Cancer
Phase Ib study to combine UbiVac’s DRibble®
Platform Vaccine, DPV-001 with anti-OX40 (BMS-986178) and Opdivo
(nivolumab) to test hypothesis that this combination will augment
anticancer immunity in advanced triple negative breast cancer
PORTLAND, Ore.--(BUSINESS WIRE)--UbiVac, Inc. (www.ubivac.com) today announced it has entered into a clinical trial collaboration with Bristol Myers Squibb Company(NYSE:BMY)
to evaluate the safety, tolerability, and preliminary efficacy of
UbiVac’s investigational product, DPV-001™, a first-in-class cancer
vaccine that exploits autophagy, in combination with Bristol Myers
Squibb’s anti-OX40 (BMS-986178) combined with sequenced administration
of the programmed death-1 (PD-1) immune checkpoint inhibitor, Opdivo(nivolumab).
The Phase 1b multicenter trial will test the hypothesis that
combination immunotherapy with the DPV-001 cancer vaccine and anti-OX40
will augment anticancer immunity in patients with advanced triple
negative breast cancer. . . .
This is the first clinical trial to combine a cancer vaccine
(DPV-001), that educates the immune system to destroy cancer cells, with
a T cell agonist, Bristol Myers Squibb’s anti-OX40 (BMS-986178), that
amplifies immune system activity. Patients also will receive
anti-programmed death 1 immune checkpoint therapy, Bristol Myers
Squibb’s Opdivo, which takes the brakes off the immune system.
If you are interested in clinical trials, many cancer centers will have a clinical trial coordinator. That person could possibly answer your questions about the clinical trials. In addition, if you go out to the clinical trial website, there is a study coordinator/contact person listed. You could contact that person directly with questions about that specific clinical trial. I agree these studies are written in scientific language and sometimes difficult to understand, but a good doctor should be able to decipher the information for you.
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
You cannot post new topics in this forum You cannot reply to topics in this forum You cannot delete your posts in this forum You cannot edit your posts in this forum You cannot create polls in this forum You cannot vote in polls in this forum