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Lulabelle39
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Topic: New Immunotherapy Trial Posted: Aug 14 2020 at 12:42pm |
I’d be really interested for an update on this trial, currently on nab-paclitaxel and atezolizumab for mTNBC in the uk and want this as my next treatment option if needed? This seems to be amazing although I can see it’s only for treatment naive in the mets setting and US based praying the open this up to the uk and as a secondary!!!!
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Mariote
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Posted: Apr 17 2020 at 6:58pm |
Ditrona wrote:
Hm, not sure how many injections she took. She took the first in the U.S., and as she is a nurse, she is able to do self-injections, so she probably took some back home as well. However, she stopped after 1 month as she was getting worse. She had a new CT, and her tumors in her lymph nodes had grown. She is now on chemo + Tecentriq, as she is PD-L1 positive. Starting to feel better:-) |
Hi Ditrona, thanks for your kind answer. There's a trial that I understand is recruiting, using a KRAS inhibitor (AMG-510) alongside Keytruda. I've heard only good things about AMG-510 and we are waiting with hope for further developments in this field.
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Ditrona
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Posted: Apr 17 2020 at 12:18pm |
Hm, not sure how many injections she took. She took the first in the U.S., and as she is a nurse, she is able to do self-injections, so she probably took some back home as well. However, she stopped after 1 month as she was getting worse. She had a new CT, and her tumors in her lymph nodes had grown. She is now on chemo + Tecentriq, as she is PD-L1 positive. Starting to feel better:-)
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Mariote
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Posted: Apr 16 2020 at 10:48pm |
@Ditrona. Oh, so your sister-in-law only got 1 injection of Leronlimab? May I ask the reason, if I am not being indiscreet? She couldn't get more because she was too weak/sick? Thanks in advance and hope your sister-in-law gets better.
Edited by Mariote - Apr 16 2020 at 10:51pm
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James123
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Posted: Apr 03 2020 at 9:56am |
This is wonderful News on this very exciting trial
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Ditrona
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Posted: Apr 01 2020 at 10:26am |
Yes, she was in California and got her first injection in early March. She then started on Carboplatin when she got back home. She has just been on Carboplatin for two weeks, but during these last few weeks, her condition has gotten worse. I just talked to my brother and they are taking her in to the hospital tomorrow, hopefully give her some stronger meds for her pain.
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James123
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Posted: Apr 01 2020 at 8:14am |
Did she get any of the drug administered at all?
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Ditrona
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Posted: Apr 01 2020 at 6:12am |
An update on my sister in law:
She entered the program in the beginning of March. She has not done any tests after this due to the corona situation, however, she is not feeling very well, bad cough and lots of pain in her body, so she is feeling pretty sure the cancer has spread all over..She will take a new CT after Easter.
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James123
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Posted: Mar 26 2020 at 6:08pm |
Has there been anymore news on this Trial and how the patients are doing.
Can you give us an update
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Ditrona
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Posted: Feb 25 2020 at 9:20am |
My sister in law is now going to participate in this trial. We got results today that she is both CCR5+ and PD-L1 positive. Hopefully she can combine both drugs (Keytruda + Leronlimab) with Carboplatin?
She has recurrence only to her lymph nodes so far. The dream would be that this combo could eliminate it all, but we’ll take all the extra time we get..
I’ll keep you posted on how things go!
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James123
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Posted: Feb 21 2020 at 2:31pm |
This is wonderful news!! It’s Amazing 😉
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123Donna
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Posted: Feb 16 2020 at 12:12pm |
Leronlimab (PRO 140) Combined With Carboplatin in Patients With CCR5+ mTNBCStudy Description
Brief Summary:
This
is a phase Ib/II Study of Leronlimab (PRO 140) combined with
Carboplatin in Patients with CCR5+ Metastatic Triple Negative Breast
Cancer (mTNBC).
Study population will
consist of patients with CCR5-positive, locally advanced or metastatic
triple-negative breast cancer (mTNBC) who are naïve to chemotherapy in
metastatic setting but have been exposed to anthracyclines and taxane in
neoadjuvant and adjuvant settings (first-line).
*******************
Contacts
Locations
United States, California |
Pacific Hematology Oncology Associates / Quest Clinical Research |
Recruiting |
San Francisco, California, United States, 94115 |
Contact: David Ruiz 415-417-3337 david@PHOAMD.COM |
Contact: Mary Gascon 415-923-3105 mgascon@phoamd.com |
Sub-Investigator: Milana Dolezal, MD |
United States, Illinois |
CD07 Investigational Site |
Not yet recruiting |
Chicago, Illinois, United States, 60611 |
Sponsors and Collaborators
CytoDyn, Inc.
Amarex Clinical Research
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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James123
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Posted: Feb 16 2020 at 9:58am |
Thank you for this information
It’s very appreciated and the drug is helping these women and that is sooooooo wonderful
Please keep us posted on this website
I know study location is California but hopefully it will be expanded to other areas of the Country as well
😊
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James123
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Posted: Feb 15 2020 at 4:44pm |
correction is it NIH APPROVED
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James123
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Posted: Feb 15 2020 at 4:41pm |
I mean it is NIH APPROVED study
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123Donna
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Posted: Feb 15 2020 at 4:21pm |
James123
I believe this is the clinical trial:
Brief Summary:
This is a phase Ib/II Study of Leronlimab (PRO 140) combined with Carboplatin in Patients with CCR5+ Metastatic Triple Negative Breast Cancer (mTNBC).
Study population will consist of patients with CCR5-positive, locally advanced or metastatic triple-negative breast cancer (mTNBC) who are naïve to chemotherapy in metastatic setting but have been exposed to anthracyclines and taxane in neoadjuvant and adjuvant settings (first-line).
Detailed Description:
Phase Ib
Phase Ib is a dose
escalation phase with 3 dose levels (cohorts) of leronlimab (PRO 140)
administered in combination with a fixed dose of carboplatin at AUC 5.
This dose finding portion of study will follow a "3+3" designed to
determine the maximum tolerated dose (MTD) of leronlimab (PRO 140)
administered as subcutaneous injection in subjects with histologically
confirmed mTNBC that express CCR5.
Phase II
Phase II is a single arm
study with 30 patients in order to test the hypothesis that the
combination of carboplatin AUC 5 intravenously and MTD of leronlimab
(PRO 140) SC will increase PFS in patients with CCR5 + mTNBC.
Study Type : |
Interventional
(Clinical Trial)
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Estimated
Enrollment : |
48 participants |
Allocation: |
Non-Randomized |
Intervention Model: |
Parallel Assignment |
Masking: |
None (Open Label) |
Primary Purpose: |
Treatment |
Official Title: |
A Phase Ib/II Study of Leronlimab (PRO 140) Combined With Carboplatin in Patients With CCR5+ Metastatic Triple Negative Breast Cancer (mTNBC) |
Actual Study Start Date : |
April 22, 2019 |
Estimated Primary Completion Date : |
March 2020 |
Estimated Study Completion Date : |
March 2022 |
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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James123
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Posted: Feb 15 2020 at 3:28pm |
and one final question to include in your update next week
Out of the 8 patients how many are getting the drug alone without the carboplatin and seeing good results and is this a FDA approved clinical trial
Thank you
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James123
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Posted: Feb 15 2020 at 12:17am |
after reviewing the results I noticed the patient with Brain Mets benefited greatly from the treatment but what about her lung and liver Mets ? Has the drug reduced those tumors like it has in the brain?
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James123
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Posted: Feb 14 2020 at 4:38pm |
Has anyone on this site participated in this clinical trial
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Suebhs
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Posted: Feb 07 2020 at 1:00pm |
I had my last chemo treatment yesterday for stage 1 tnbc. I was very fortunate in that it was discovered early during a routine ultrasound mammogram My oncologist participates in research studies and he was telling me they're doing very promising things right now with immunetherapy. Prayers that this will be the answer and hope for so many 🙏🙏🙏
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