Unfortunately it didn´t helped......

Hi,

Sorry it has been a while, since I have posted on this website.
After being cancer free for 1 1/2 year, I got a chok. I have been following Jane Plants book, about healing cancer by avoiding all kinds of dairy, meat etc. But it didn´t helped. I got a regular PET/CT scan for follow up (sep 09), and I got really bad news. The cancer has returned in my bones and lungs. To begin with I was really bad, couldn´t breath, couldn´t walk 5 min because of bad breathing. Mentally I have been really down. I am on chemo again CMF (a 20 year old chemo)so I am just thinking can that help. But I have heard that the combination is good for triple negative.
After receiving chemo, I am now feeling much better. I walk every day for 20 min without difficulties, so I see that as a good sign.
Mentally I am up again. A person, who unfortunately is not here any longer because of breastcancer, told me: We have one road to walk on, try to walk that as positive as you can. That has helped me to climb up again from the darkest hole.
I hear this song too, that really tells me to fight, and that there will always me another mountain to climb. http://www.youtube.com/watch?v=NG2zyeVRcbs.
The thing who makes me really sad, is that if not a miracle is going to happen, I will not be able to see my three kids grow up (9, 7, 4).
I know that I will not be here for them, so therefore I have started to record my life on a tape. I tell them things that only I know, I tell them about everything, so when I am not here longer they can listen to the tape and know a lot about me, also in the future.

Take care all of you, I just wanted to share my story.

Dane (Rikke)

Dear Dane,

Found 11 studies with search of:

parp inhibitors brca

Hide studies that are not seeking new volunteers.

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Rank	Status	Study
1	Completed	Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-Positive Advanced Breast Cancer Condition: Breast Neoplasms Intervention: Drug: KU-0059436 (AZD2281)(PARP inhibitor)
2	Completed	Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-Positive Advanced Ovarian Cancer Condition: Ovarian Neoplasm Intervention: Drug: KU-0059436 (AZD2281)(PARP inhibitor)
3	Active, not recruiting	Dose-finding Study Comparing Efficacy and Safety of a PARP Inhibitor Against Doxil in BRCA+ve Advanced Ovarian Cancer Condition: Ovarian Neoplasms Interventions: Drug: AZD2281;   Drug: Liposomal Doxorubicin
4	Active, not recruiting	A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of Poly ADP-Ribose Polymerase-1 (PARP) Conditions: Ovarian Neoplasms;   BRCA1 Protein;   BRCA2 Protein Intervention: Drug: KU-0059436 (AZD2281)(PARP inhibitor)
5	Recruiting	AZD2281 and Carboplatin in Treating Patients With BRCA1/BRCA2-Associated, Hereditary, or Triple Negative Metastatic or Unresectable Breast Cancer or Ovarian Epithelial Cancer Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2);   Ovarian Cancer Interventions: Drug: carboplatin;   Drug: olaparib;   Genetic: polymorphism analysis;   Other: enzyme-linked immunosorbent assay;   Other: laboratory biomarker analysis;   Other: pharmacogenomic studies
6	Recruiting	MK4827 in Patients With Advanced Solid Tumors and BRCA Mutant Ovarian Cancer Conditions: Solid Tumors and Ovarian Neoplasms;   Ovarian Neoplasms Intervention: Drug: Comparator: MK4827 (PARP inhibitor)
7	Active, not recruiting	A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients Conditions: Non-hematologic Malignancies;   Metastatic Melanoma;   Breast Cancer;   Ovarian Cancer;   Primary Peritoneal Cancer;   Fallopian Tube Cancer;   Hepatocellular Carcinoma Interventions: Drug: ABT-888;   Drug: Temozolomide
8	Active, not recruiting	Phase II Study of AZD2281 in Known BRCA or Recurrent High Grade Ovarian Cancer or Known BRCA/ Triple Neg Breast Cancer Conditions: Ovarian Carcinoma;   Breast Cancer Intervention: Drug: AZD2281
9	Recruiting	AG014699 in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Ovarian Cancer Interventions: Drug: PARP-1 inhibitor AG014699;   Genetic: protein expression analysis;   Genetic: western blotting;   Other: immunohistochemistry staining method;   Other: liquid chromatography;   Other: mass spectrometry;   Other: pharmacological study
10	Active, not recruiting	Single Arm Study of BSI-201 in Patients With BRCA-1 or BRCA-2 Associated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Conditions: Primary Peritoneal Cancer;   Advanced Epithelial Ovarian Cancer Intervention: Drug: BSI-201
11	Not yet recruiting	Carboplatin, Paclitaxel, Bevacizumab, and ABT-888 in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Conditions: Fallopian Tube Cancer;   Ovarian Cancer;   Peritoneal Cavity Cancer Interventions: Biological: bevacizumab;   Drug: ABT-888;   Drug: carboplatin;   Drug: paclitaxel

Dane, you are a such a sweet, good person. What a terrible shock you have received.  What a hard road to travel, and you are clearly walking it with a lot of love and grace.   Making those recordings is a great idea, though I hope and pray that your kids won't need to listen to them for a long, long time, after they are grown. 

Much luck with this new chemo.  It is great that you are feeling better and walking lots again.

Love,
Denise

http://www.clinicaltrials.gov/ct2/results?term=parp+inhibitors+brca

Dane -

Hello Denise - thanks for your reply. Both the first diagnosis and the reoccurrence were just by me knowing something wasn't right. Niether were picked up by mammo's. I had a PET scan done in Oct. that was clean and by the end of Nov. I had a 5 cm cyst in my breast. They told me at first that because it was a local reoccurrence that was good but then I had another PET scan and it showed the spot on my spine. Thanks for the information on the Zometa! I have had some people approach me about if I was on a special diet - I was reading about going organic - any suggestions?

i am so sorry... may God be with you and your family at this time and always.

Dear Rikke's husband.  I am so sorry for your loss.  Would you say a few words about her life, or paste in her obituary summary?  We'd like to make a tribute page for her in the tribute subforum, so her precious life and all she suffered can be remembered by this community.
Love,
Denise


Edited by dmwolf - Apr 05 2010 at 3:32pm

Dear Rikke's husband and children:

Hi Denise

Thanks for the nice words, and yes she left a lot of movie and voice recording where she tells about her childhood.. she now lives through our 3 kids, and they have all the same nice personality. My love was very very special and we will miss her a lot.

Our frends from USA, made this movie from the time they visited us in Denmark: http://www.youtube.com/watch?v=zi-YdIx7E3w

Love,
Jan