Caveolin 1 overexpressed in Basal Like |
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trip2 
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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 Topic: Caveolin 1 overexpressed in Basal LikePosted: Jul 04 2007 at 4:33am |
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In normal breast, CAV1 was expressed in myoepithelial cells, endothelial cells, and a subset of fibroblasts. Luminal epithelial cells showed negligible staining. CAV1 was expressed in 90% of 39 metaplastic breast carcinomas and in 9.4% of 245 invasive breast cancers. In the later cohort, CAV1 expression was significantly associated with ‘basal-like’ immunophenotype and with shorter disease-free and overall survival on univariate analysis. CAV1 gene amplification was found in 13% of cases with strong CAV1 expression.
Conclusions: The concurrent CAV1 amplification and overexpression call into question its tumor-suppressive effects in basal-like breast carcinomas. |
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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