BRCA1 and BRCA2 variants

Hi,

No earth shattering info.....yet.......just a thread for info/resources for BRCA1 and BRCA2 variants.

Interesting article.
http://www.genomeweb.com/clinical-genomics/competition-coming-myriads-brca-test-whether-or-not-gene-patents-hold
It included the following:
....."Myriad's key patents underlying its flagship BRACAnalysis are being challenged in the case Association for Molecular Pathology et al. vs. Myriad. The Supreme Court heard arguments in the case on April 15 and is expected to issue a decision sometime in June. Even if Myriad prevails, and its patents on large swathes of BRCA1 and BRCA2 genes are not invalidated by the court, some of these patents are slated to expire starting in 2015........"
....." A genetics researcher at the University of California, San Francisco, however, is quietly building a public database containing BRCA1 and BRCA2 variants, that he hopes will become the go-to resource for other labs who in the future perform BRCA testing. Just over a year ago, Robert Nussbaum began emailing cancer clinics that order genetic tests for women with a family history of breast and ovarian cancer to make a simple request. He asked whether they would submit de-identified data from patients tested for mutations in BRCA1 and BRCA2 genes to a publicly accessible database, called ClinVar.
A number of clinics agreed and to date ClinVar has amassed data on approximately 1,000 unique BRCA 1 and BRCA 2 variants, around one third of which have not been seen before. Nussbaum, head of the medical genetics division at the University of California, San Francisco, estimates that the amount of data on BRCA1 and BRCA2 genes contained in ClinVar today is about 1 percent of the information accumulated in the proprietary database held by Myriad..........."


FYI: See also thread on BRCA testing:
       http://forum.tnbcfoundation.org/very-important-news-re-tnbc-brca-testing_topic8458_page1.html?KW=BRCA


With caring and positive thoughts,
Grateful for today...........Judy

Thanks Judy.  As a VUS result person any and all updates are interesting.