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BrynnaK View Drop Down
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    Posted: Nov 24 2020 at 5:13pm
My wife has triple negative metastatic BC and is planning to start a chemo cocktail called CMF. Does anyone have experience with CMF for metastatic patients? I know it was usually used for early diagnosed patients. I would like to hear experience of others who have tried CMF.
Thanks, Brynna
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Nov 25 2020 at 8:42am
Hi Brynna,

CMF was a common chemotherapy combination used for adjuvant treatment.  With the introduction of anthracyclines, it's been replaced as the standard for early breast cancer.  I read about 10% use of CMF now, but one study showed it may be more effective with basal subtypes than anthracyclines. 

For metastatic treatment, has she had other chemo or is this the first line of treatment?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743994/







DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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BrynnaK View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote BrynnaK Quote  Post ReplyReply Direct Link To This Post Posted: Nov 25 2020 at 9:16am
Thank you. I read somewhere that it had made a comeback and is being used with more advanced cancers. Rosemary has had about every standard chemo available. We are out of options, except for CMF and clinical trials. I read that it can be effective with TNBC. 
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BrynnaK View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote BrynnaK Quote  Post ReplyReply Direct Link To This Post Posted: Nov 25 2020 at 9:52am
The first article was helpful. I couldn't find an article related to CMF in the second link. 
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SagePatientAdvocates View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Nov 28 2020 at 6:38pm
Hi BrynnaK,

Welcome to our TNBC forum. Sorry your wife has mTNBC. My experience with helping women who received CMF with mTNBC is very mixed. I think the Korean study 
123Donna found is interesting and I also found a recent article that you may find of interest.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980632/

The group of authors are quite diverse-Russia, U.S. and Israel.

This is a study involving one 48 year old woman who had a partial response with Elanagen and CMF. I am not a medical professional and will not give you/your wife medical advice
so I am not saying you should try this combination or not but I found the study interesting.

I am a patient advocate and have helped many on this site over the last 10 years. But again, I am not a medical professional but might be able to refer you to a mTNBC 
knowledgeable breast medical oncologist. In these awful Covid days some wonderful oncologists will only see a patient in-person for the first consult and others will do Zoom conferences. Challenging times.

If you would like to discuss with me I would be happy to...You can send me a PM and I will send you my phone number and email contact. If you prefer you can write me at
contact@sagepatientadvocates.info and I can set-up a Zoom conference. There are no charges.

warmly,

Steve
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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BrynnaK View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote BrynnaK Quote  Post ReplyReply Direct Link To This Post Posted: Nov 30 2020 at 3:08pm
Thank you very much for the information in Elenagen. It sounds promising. I tried to find on the Internet if Elenagen is considered immunotherapy, but couldn't understand the answers. Do you know? Rosemary is unable to use immunotherapy because of another illness she has. 
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SagePatientAdvocates View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Nov 30 2020 at 3:41pm
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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