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toatley75 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote toatley75 Quote  Post ReplyReply Direct Link To This Post Posted: Jun 20 2013 at 3:03pm
I have questions about premeds.  I currently take Benadryl, Ativan, Decadrun and Zantac as part of my pre meds. I know the reason for taking all of these before chemo, but I was wondering if anyone else has taken these as part of pre meds and what their experience was with it or premeds in general. I'm not sure which of these meds it is that makes me feel very flushed, naseauated, and just plain drunk.  I had my doctor reduce the ativan by 1/2 for my second treatment but that made it worse.  Anyhow, I just wondering if anyone would like to share their experiences with premeds. :-)
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MLindaG View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MLindaG Quote  Post ReplyReply Direct Link To This Post Posted: Jun 20 2013 at 6:28pm
toatley,  Hi!  Hope you are feeling OK.  I took some type of anti nausea premed and Decadron (steriod) as premeds when I had A/C and the bendryl, anti nausea drug and decadron with taxol. The premeds are supposed to help you through the first day of receiving the chemo.  I felt the effects of the chemo within 4-6 hrs.   The feeling of "just plain drunk" makes me think of what I used to call "I'm in a fog" which I always thought of as "Chemo brain".  The Chemo is making you nauseated..........that's why they are giving you all the anti-nausea drugs as premed and oral.  I started by taking one (compazine) which after 6 hrs. I was still very nauseated.........I then took zofran and the compazine...........then I just felt slightly nauseasted all the time.  It was like back when I was pregnant........LOL  Not everyone gets as nauseated as I did  but if you talk to old time chemo patients it was very common for them to throw up a lot.  I never threw up (Thank goodness) After my 2nd round I took a patch as well as the zofran and compazine and after the third round I took another drug that made me sleepy plus the patch, zofran and compazine!!  So.......I'm not sure but it seems like it is the Chemo causing all the havoc!  
Dx TNBC 6/12; age 59; Stage 3, Grade 3; 3.5 cm, 3/10 nodes + chest wall nodes; A/C x4, T x 12 completed 12/12 with PCR, 2/13/13 lump; IMRT Rads x 33 completed 5/22/13 BRCA 1 negative.
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toatley75 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote toatley75 Quote  Post ReplyReply Direct Link To This Post Posted: Jun 20 2013 at 6:39pm
The pre meds are what i get before i even receive my chemo so I know it's the pre meds that are making my body feel this way. I also take emend by mouth before I go in and zofran the next 3 days. Then compazine is my relief medicine after that if I need it. Im like you and have had some nasuea but never have thrown up.
TNIDC T2 N1 M0 Stage 2B Diagnosed 4/30/13 AC Started 5/24 4 cycles every 3 weeks
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MLindaG Quote  Post ReplyReply Direct Link To This Post Posted: Jun 20 2013 at 11:26pm
I felt fine for about 4-5 hrs.  I would go out for lunch after my chemo.  Hope you figure out what is causing your problem.  :)  No fun huh? 
Dx TNBC 6/12; age 59; Stage 3, Grade 3; 3.5 cm, 3/10 nodes + chest wall nodes; A/C x4, T x 12 completed 12/12 with PCR, 2/13/13 lump; IMRT Rads x 33 completed 5/22/13 BRCA 1 negative.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote dkmoore2 Quote  Post ReplyReply Direct Link To This Post Posted: Jun 21 2013 at 8:41am
I got really sick - vomiting etc. and couldnt eat or drink with the a/c chemo and pre meds.  What helped me the most (was on Ativan and other premeds) going back in on day 3 and 4 for hyrdration.  Last two of my 4 rounds were much much better.  Now getting Taxol 1st round which laid me out flat for 4 days with so much pain.  So, if someone has a trick to relieve the side effects of this chemo would be happy to hear it.
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toatley75 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote toatley75 Quote  Post ReplyReply Direct Link To This Post Posted: Jun 27 2013 at 10:20am
My doctor and I figured that I was sensitive to Benadryl and she is going to put it in a drip for me to dilute it even more. I can handle everything else that has been going on with me, but the flushed, nausea, and extreme sleepiness feelings I feel when they IV push the Benadryl is something I can't take.  I have two more of these and then will start the Taxol weekly for 12 weeks. I have had some side effects, the worst being stomach issues like reflux and constipation.  I hope my side effects are limited also when I start the Taxol because I will be working again (I'm a teacher on summer break right now) and it will be a lot more challenging then. I hope your side effects get better dkmoore2.  
TNIDC T2 N1 M0 Stage 2B Diagnosed 4/30/13 AC Started 5/24 4 cycles every 3 weeks
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MLindaG View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MLindaG Quote  Post ReplyReply Direct Link To This Post Posted: Jun 27 2013 at 4:31pm
toatley,  Now that I think about it I did have trouble with the first benedryl(it was a drip but they did it in 10 min.) .........I had the shakes, felt awful and could barely make it to the bathroom without help........they gave it to me over 45 min. instead of the quick way they usually give it.  I did fine.  At the time the facility had never had my symptoms before and didn't know what to do.........so I called my girlfriend in CT who had gone through chemo  a couple years before me and was my go to about everything chemo and she had heard about having it go in slower........so they said they would try it - it worked.  So I had numerous chemo nurses tell me I was famous for this new way of giving benedryl for anyone with a problem!!! LOL  I thought to myself........it seem to make so much sense to me........slow it down so my body doesn't go crazy!!  I did still sleep for the hour it took for the taxol but woke up and felt great after that.  :)  It is interesting how after we are done with something we put it right out of our minds!  (Such as childbirth!)  I didn't get benedryl with the A/C.  
Dx TNBC 6/12; age 59; Stage 3, Grade 3; 3.5 cm, 3/10 nodes + chest wall nodes; A/C x4, T x 12 completed 12/12 with PCR, 2/13/13 lump; IMRT Rads x 33 completed 5/22/13 BRCA 1 negative.
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miz View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote miz Quote  Post ReplyReply Direct Link To This Post Posted: Jul 04 2013 at 10:59am
I found a lump on my breast 4.1 had all the test and a biopsy and my doctor said it was DCIS. Continued with a Pet / CT scan and blood work ekg, Eco 3D and by the time I went to see an oncologist every thing changed. She said I have triple negative invasive stage 11A. Blew me away. Got a port installed and had my first treatment of A/C chemo on Tuesday. Chemo went very smooth and I feel pretty good. today is day three. Don't really know what to expect... but so far so good. Glad I had a port put in. No problem with the port so far. I will have 4 treatments of a?c an 4 treatments of Taxoil. Still up in the air about lump or full masectmey... any suggestions.
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MLindaG View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MLindaG Quote  Post ReplyReply Direct Link To This Post Posted: Jul 04 2013 at 12:53pm
miz, Are they going to do the genetic testing?  They told me that if I was BRCA1 + I would have a mastectomy.......if not they said there is no difference with outcome between the two and suggested a lumpectomy.  I was BRCA1 and 2 negative and decided to do the lumpectomy.  So far so good but then again I just finished with the whole process in May of this year.  I think if you do a search you'll will find others opinion on this subject and I'm sure others will chime in here if they see your question.  Sounds like you are doing fairly well so far which is good!!  Good luck!
Dx TNBC 6/12; age 59; Stage 3, Grade 3; 3.5 cm, 3/10 nodes + chest wall nodes; A/C x4, T x 12 completed 12/12 with PCR, 2/13/13 lump; IMRT Rads x 33 completed 5/22/13 BRCA 1 negative.
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