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Bad taxol reaction anyone?

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Jacklin View Drop Down
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    Posted: Feb 12 2016 at 5:02pm
Hello everyone,

I've completed 4 dose-dense A/C treatments and last Friday had my 1st (of 4) taxol.  On Saturday my hands and feet were very warm but by Sunday they were fire-engine red and I lost sensation in my toes and fingers. It also felt like there were blisters under the skin. I did speak with my oncologist and she said it was NOT peripheral neuropathy, but a neurotoxic reaction to the taxol. It's been an awful week, hardly able to walk on my feet, craving cool items to place near the skin, using fridge-cooled cream on my hands & feet along with socks and gloves to protect them and now lyrica to help with the pain. Thankfully I'm in less pain today but still no sensation in the fingers/toes. I'm wondering if anyone else had this type of reaction, what you did to combat the pain and what the next steps were for chemo, when did the sensation return to your fingers and toes? Any suggestions would be welcome. My next chemo will be Fri/19, I see the oncologist on the 18th to discussion chemo options, but having others' input would be helpful. I can't thank you all enough for sharing so openly here, it is SO helpful and bring tremendous comfort. You are all so strong  and this brings me encouragement to 'hang in there' when I'm not having such a good day myself. Surgery for me is next and then radiation - I'm sure I'll be posting again soon. Have a wonderful weekend everyone and thank you in advance!
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MikeW View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote MikeW Quote  Post ReplyReply Direct Link To This Post Posted: Feb 12 2016 at 10:25pm
My wife back in 2013 when she was initially diagnosed had a severe reaction to taxol. It happened in the infusion room. Crash cart, nurses and doctors coming out of the wood work. She passed out for a time. Also a strong and violent reaction to neulasta. Quick ER visit, etc.

She's had her lifetime amount of AC then 7 weeks of radiation to clear up ER+ in breast (breast and 19 lymph nodes removed). Also metaplastic triple negative breast cancer in lymph nodes. She's NED for now
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Post Options Post Options   Thanks (1) Thanks(1)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 13 2016 at 12:10am
Jacklin,

I didn't have Taxol, but Taxotere.  I had a severe rash/hives reaction after the 3rd treatment with terrible itching.  Steroids helped relieve the symptoms.  Hope your symptoms improve.

Here are a couple of links discussing Taxol side effects:






DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote barrycarrot Quote  Post ReplyReply Direct Link To This Post Posted: Mar 01 2016 at 3:05pm
I start Taxol on Friday and am nervous as heck. I'm afraid of just what you all posted. I'm so hoping it goes smoothly. AC was pretty easy so I'm afraid Taxol is going to get me. I hope these reactions are not the norm.
 
Carrie
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Jacklin View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jacklin Quote  Post ReplyReply Direct Link To This Post Posted: Mar 01 2016 at 3:39pm
Hi Carrie,

I am so sorry if my post has made you nervous. Please know that not everyone has a reaction like I did - my oncologist said that in her 20 years of being in oncology, this was the first time she'd ever seen a reaction like mine. Do know that the nurses will be keeping a close eye on you when you have your taxol on Friday. First you will get the steroid (ondansetron) in the IV for about 15 minutes , then the Benadryl (about 30 minutes) and then finally the taxol (about 3.5 hours) . You will probably be very sleepy by the time they give you the taxol - I know that I basically slept through my first infusion. 

Again, apologies if my posting scared you, that wasn't my intent. I was just wondering if anyone else had that reaction too. I"ll be praying for you on Friday. 


Dx: Nov. 27/15, TNBC, left breast & lymph, BRCA -; Chemo: Dec 4/15 - Mar 4/16; 4 DD A/C, 3 DD Taxol; BMX/ALND: April 26/16; Stage 3C; Radiation: June 10-July 15/16; 1 cycle Xeloda: Aug 15 - 28/16
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Mar 01 2016 at 4:00pm
You might ask your oncologist if you're a candidate for Abraxane. It is often substituted for taxol when taxol induces bad side effects. I don't know if it would be appropriate for you, and you'll need to be sure your insurance covers it, but it was really great for my sister when she had issues with taxol. Best of luck!
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote AmyL Quote  Post ReplyReply Direct Link To This Post Posted: Mar 01 2016 at 4:16pm
Hi Jacklin,

I'm sorry about your Taxol reaction. I know my oncologist said that they do dose dense A/C two weeks apart, but do less concentrated Taxol weekly x 12 to lessen the side effects. I wasn't thrilled about dragging treatment out for 20 weeks but I have put my trust in them. Maybe the dose dense Taxol was too much for your system?

Prayers coming your way

Amy
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Post Options Post Options   Thanks (0) Thanks(0)   Quote barrycarrot Quote  Post ReplyReply Direct Link To This Post Posted: Mar 01 2016 at 8:00pm
It's OK Jacklin. I'm hopeful it will go smooth. I hate to hear of anyone struggling. I'm sorry you had to go through that. I appreciate your prayers for Friday and will be praying for you too!

Carrie
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Jacklin View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jacklin Quote  Post ReplyReply Direct Link To This Post Posted: Mar 01 2016 at 9:07pm
Hi Carrie,

Thank you for your prayers - my 3rd (of 4) taxol treatments will be on Monday, as long as my bloodwork is good on Friday. How wonderful that we can support each other through prayer - it's an honour and privilege for sure. 

Peace,
Jacklin


Dx: Nov. 27/15, TNBC, left breast & lymph, BRCA -; Chemo: Dec 4/15 - Mar 4/16; 4 DD A/C, 3 DD Taxol; BMX/ALND: April 26/16; Stage 3C; Radiation: June 10-July 15/16; 1 cycle Xeloda: Aug 15 - 28/16
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Post Options Post Options   Thanks (1) Thanks(1)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 02 2016 at 3:04pm
Jacklin, my wife had Taxotere ( the Taxol family of chemo drugs) in 2008, she had some issues with big toenails falling off , but mainly it affected her intestine. She had IBS, which she still has today, but she's found some remedies.

She finished Taxol about 5 weeks ago, again it has aggravated her intestine. This is common,., but she's alive.

 The sinus problems and intestine are caused by the chemo attacking the smallest reproducing cells, like mucous membranes, so it's not uncommon.

She takes acidophilis pills, and the fiber from Rite Aid, and an enzyme pill to aid in digestion, they have all helped her get thru this. It's not perfect, but after chemo, it gradually improves...I can post the products if anyone is interested.

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