Avastin & Abraxane - Anyone Else? |
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trip2 
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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 Posted: Aug 06 2008 at 5:25am |
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Oh CarynRose were they able to get the gastric bleeding stopped or did it stop on it's own because you halted your Avastin?
Bless your heart, I so hate that women are having to go thru all of this but that is good news that the Avastin is being helpful indeed.
Big hug,
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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another nancy
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Joined: Jul 18 2008 Location: United States Status: Offline Points: 10 |
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Posted: Aug 06 2008 at 6:02pm |
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It is good to hear that others are doing some type of maintainence avastin and it is working for them. My onc is talking about doing the same thing with me. I wonder if it is the avastin giving you the painful poops....is one of my side effects also...This week they gave my a different type of anti-nausea medication and not having as many issues. I got some good news today. Again, I have just completed by third cycle of Abraxine and Avastin. I had a PET/CT on Monday and my results came back as no evidence of disease....I just love NED....he is my pal now. I will be doing 3 more months of the A/A. I am so happy.....
Another Nancy
1/08 DX
Neoadjuvent A/C 2/08
Mastectomy 4/08 Stage Stage 3B 4/7 nodes
PET 5/08 revealed subclavicular, mediastinum mets
5/08 Abraxine/Avastin
8/08 NED
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cg---
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Joined: Jul 20 2007 Location: Canada Status: Offline Points: 1379 |
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Posted: Aug 06 2008 at 9:57pm |
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Dear Another Nancy,
How wonderful you have had such amazing results. I hope that you will be dating NED for a very long time!
Cyber Hugs,
Connie
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CarynRose
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Joined: Aug 04 2007 Location: Robbinsville, NJ, USA Status: Offline Points: 960 |
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Posted: Aug 07 2008 at 2:14am |
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Another Nancy --
CONGRATULATIONS on dancing with NED. He's a wonderful partner.
Pam, yes, after 3 weeks off of Avastin, my bleeding subsided and all seems to be well. They added Pepcid to my premeds yesterday so that my tummy would be more protected and I'm happy to report (get ready for TMI) that this morning's poop was perfectly normal and not painful.
I'm very happy to be back on the Avastin. I feel like it's my safety net.
Cheers,
Caryn
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Orig dx 6/03 - St.2a, IDC
gr.3,0 nodes, TNBC/BRCA1+ 7/07 St 4 mets to nodes/lungs. PACA/Rads NED 11/07-10/08 Lepto mets 10/08 Rads for 4 brain tumors 4/10. Leptomets return 6/10 |
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trip2
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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Posted: Aug 07 2008 at 8:34am |
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CarynRose I am happy to hear things are back to "normal". lol
Another Nancy, my congratulations for your meeting NED!
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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JulieG
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Joined: Jun 17 2008 Location: United States Status: Offline Points: 46 |
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Posted: Aug 07 2008 at 1:18pm |
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My congrats also Another Nancy on meeting NED. I have a question though, what is NED? I know it's something good but that is one acronym that I am unfamiliar with. CarynRose, I am glad you brought up the issue of painful poops. I also have the same side side effect. I am going to ask for pepcid to counteract it. I hate the painful poops, it's almost like having a baby everytime I go to the bathroom. I just got out of the hospital today. I had fiducials implanted (little pellets) for the Cyberknife procedure I am about to go thru. They told me it would be painless because you don't really feel pain in your liver. THEY LIED!!!! I felt everything. (They didn't really lie, I am just wierd and feel everything in my liver.) They ended up having to give me tons of morphine and kept me in the hospital overnight so I could stay medicated. But as you know every cloud has a silver lining. Because I am back on morphine I was able to eat a hamburger! My first solid food in FOUR weeks. I have esophagitis from radiation. It was the most wonderful hamburger I ever ate. I promised my Onc Nurse Practitioner that I would stay on morphine for a while to be able to heal. So I am going to have fun eating too! JulieG |
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Dx 2/07 TN
Mastec Lft Brst, 11 lym node Cytoxin/Taxotere 6mth biwkly Mets to lung, liver and lymph nodes 12/07 Ixempra/Avastin/Xeloda 6mths Rad x14 Avastin/Abraxene every 21 days |
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Nancy
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Joined: Jul 23 2007 Location: Altoona, PA Status: Offline Points: 3814 |
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Posted: Aug 07 2008 at 1:25pm |
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JulieG,
NED is "No Evidence of Disease"! By the way.....Congratulations Another Nancy!! Words every gal here and any one else dx with cancer wants to hear
 Hugs,
Nancy
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thinkpositive
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Joined: Jun 24 2007 Location: United States Status: Offline Points: 111 |
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Posted: Sep 03 2008 at 4:25pm |
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Julie G - I also have lung mets and am on Avastin and Abraxene. I was curious as to whether it was working for you. Also, saw that you were going through a cyberknife procedure, was that for your lung mets?
Hope you are doing well. Sorry you had to do the hospital thing.
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dx 3/06 stg II 0/7 lymph
bilateral mastectomy 7/06 AC/Taxol lung mets 1/08 Avastin Abraxene 02/08/9/08 Brca neg Avastin Xeloda 10/08 Curagen 2/09 Ixempra 6/09 Lung Mets Gemzar/ Carboplatin 9/09 |
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Madison
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Joined: Mar 05 2008 Status: Offline Points: 10 |
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Posted: Sep 03 2008 at 6:05pm |
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Hi everyone, I haven't posted for awhile. I was on the Ixempra thread but it didn't work for me so now I'm on Abraxane/Avastin/Zometa. I have bone, liver, and lung mets. I've been on this combo for three months and just recently had a scan. Everything is stable with mild improvement! So I can say this has worked so far for me. Good Luck everyone. Maddie
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trip2
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Joined: Jun 03 2007 Location: Under Palm Tree Status: Offline Points: 8549 |
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Posted: Sep 04 2008 at 5:45am |
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Maddie,
I am so glad that the new meds have worked for you! That is fabulous, congratulations!!
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Stage 2 2003
Stage 1 2007 BRCA 1+ |
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Wendy2
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Joined: Apr 10 2008 Location: United States Status: Offline Points: 213 |
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Posted: Sep 04 2008 at 9:13am |
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Great News Maddie! YEA.
I also have been on Abrx/Avstn. Sept. 2 was my LAST treatment. I stopped 4 treatments earlier than prescribed - becaused I ASKED! I find it incredible how much you have to manage your own health - especially in this situation and with a great doctor/onc.
 The hope when treating mets. is to shrink, destroy, the tumors and to have NO side effects of cancer; so when my lung mets symptoms were gone after three treatments and my July PET and CT were extremely well and my cancer tumor numbers were NORMAL, AND when I started feeling a bit crappy, I asked WHY DO I HAVE TO CONTINUE ON THIS only to have the chemo side effects make me feel bad? Onc. said "Well every chemo protocol is made up of even number of treatments and that's just the prescription", so I said well with markers normal, I mean really normal, CEA .7 that's point 7, 5 being normal and CA127-129 being 31, do I really want to continue this med. and feel worse and worse. He said, "reasonable question and No you don't." So I'm on Avastin for maintenance and my crappy feelings are going away and my MENTAL health has improved SO much. Just another reason for all of us to be here and learn from each other so we can be advocates of our own health! Cheers to you Maddie and all of you who are positively making progress!  |
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dx 3/06 TN, taxotere/cytoxin x4; radiation x 40; mets. to lungs, lymph nodes 3/08 - to begin chemo 4/29/08 Abx/Avas., 9/08 Avastin maintenance, 1/09 - off meds to see if Avastin causing headaches
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cmtrots
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Posted: Sep 04 2008 at 12:18pm |
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Happy for you:) I'm also on abrx/avstn. and would like to know if it gave you headaches?
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thinkpositive
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Joined: Jun 24 2007 Location: United States Status: Offline Points: 111 |
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Posted: Sep 04 2008 at 1:52pm |
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Wendy 2 - great news. I hope my last combo treatment was today. I am having another scan and MRI in 2 weeks and my next Avastin in 3 weeks. The last scan showed all but one small spot on the lung so keep your fingers crossed. Your results give me a lot of positive vibes.
Stay well.
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dx 3/06 stg II 0/7 lymph
bilateral mastectomy 7/06 AC/Taxol lung mets 1/08 Avastin Abraxene 02/08/9/08 Brca neg Avastin Xeloda 10/08 Curagen 2/09 Ixempra 6/09 Lung Mets Gemzar/ Carboplatin 9/09 |
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another nancy
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Joined: Jul 18 2008 Location: United States Status: Offline Points: 10 |
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Posted: Sep 04 2008 at 3:20pm |
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cmtrots, I have been on abraxine/avastin for 4 months. I get terrible headaches about 2 days after chemo. The headaches after each treatment has gotten progressively worse. The good thing is that the next day I am fine. I normally have terrible sinus infections this time of year so and it has been so hot /high pollen count, I am sure this was a contributing factor. I was also cleaning out closets and got a nose full of dust..... Beside nose bleeds, these are the only side effects I have. I will tolerate that since this chemo regime has worked great for me.
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Original DX 1/31/08
Port - Neoadj Chemo 2/07 A/C Rt Mast 4/08 Stage 3B 4/7+ nodes 5/08 PET - subclavicular /mediastinum node+ 5/08 Chemo Abraxine/Avastin 8/08 NED More chemo and rad to follow |
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Wendy2
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Joined: Apr 10 2008 Location: United States Status: Offline Points: 213 |
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Posted: Sep 04 2008 at 3:25pm |
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I didn't get headaches with Abrx/Avstn.
I still have lung nodules but they are smaller.
Good luck.
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dx 3/06 TN, taxotere/cytoxin x4; radiation x 40; mets. to lungs, lymph nodes 3/08 - to begin chemo 4/29/08 Abx/Avas., 9/08 Avastin maintenance, 1/09 - off meds to see if Avastin causing headaches
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CarynRose
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Joined: Aug 04 2007 Location: Robbinsville, NJ, USA Status: Offline Points: 960 |
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Posted: Sep 04 2008 at 3:32pm |
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another nancy,
I got TERRIBLE headaches after Avastin and figured out that it was a high blood pressure headache. It would last a day or so after treatment. I was VERY worried about it and they reinstated giving me steroids before my infusion. Sure enough, I don't get the headaches anymore and my blood pressure remains normal.
You might want to bring this up to your docs.
All the best,
Caryn
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Orig dx 6/03 - St.2a, IDC
gr.3,0 nodes, TNBC/BRCA1+ 7/07 St 4 mets to nodes/lungs. PACA/Rads NED 11/07-10/08 Lepto mets 10/08 Rads for 4 brain tumors 4/10. Leptomets return 6/10 |
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another nancy
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Posted: Sep 04 2008 at 3:42pm |
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Caryn Thanks for the insight. My BP is normally very low so this is a possibility and one of the listed side effects. I will discuss with my doc this week. N
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Original DX 1/31/08
Port - Neoadj Chemo 2/07 A/C Rt Mast 4/08 Stage 3B 4/7+ nodes 5/08 PET - subclavicular /mediastinum node+ 5/08 Chemo Abraxine/Avastin 8/08 NED More chemo and rad to follow |
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CarynRose
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Joined: Aug 04 2007 Location: Robbinsville, NJ, USA Status: Offline Points: 960 |
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Posted: Sep 04 2008 at 4:21pm |
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My BP tends to the low end too. Probably why the change caused the headaches.
Good luck,
Caryn
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Orig dx 6/03 - St.2a, IDC
gr.3,0 nodes, TNBC/BRCA1+ 7/07 St 4 mets to nodes/lungs. PACA/Rads NED 11/07-10/08 Lepto mets 10/08 Rads for 4 brain tumors 4/10. Leptomets return 6/10 |
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lilysmomac
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Posted: Sep 04 2008 at 6:25pm |
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Hi. I am new on these posts, but have been so inspired by all of your amazing spirits and stories! My sister has Stage 4BC with mets to pretty much all of her bones and to her liver. She has most recently been on Avastin and Abraxane, and it was discontinued because of progression. From the time of about the last 4 treatments on she has had really severe leg/ knee/ hip pain. She is SUPER tough, but has been in terrible pain lately that has caused her to be on around the clock narcotics. She had been on Vicodin, but over the past few days her onc has been trying her on Oxycontin. THe Oxycontin dies pretty much nothing to the pain. Is this pretty unusual for such a srong med? Has anyone out there experienced this severe leg pain with the Avastin/ Abraxane combo, and has anyone found some good treatment to minimize the pain?
Thanks so much! Ang's Sister... Angela's Stats... 01/07 St IV mets to bones, liver, and blood 03/07 Clinical Trial using HDAC inhibitor & Fec100 shrunk primary tumor from 5X4cm to immeasurable 06/07-07/07 Tamoxifen trial- unsuccessful 07/07-12/07 Arimidex- stable disease 12/24/07- rapidly growing tumor in opposite breast as primary 01/08- Bilat mast 02/08- growth of disease to outer chest wall 02/08-06/08- Carboplatin & Taxotere... stable bones and liver, mild progression to chest wall 06/08-08/08- Avastin & Abraxane... progression of liver 09/04/08- awaiting approval for new clinical trial! |
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cg---
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Joined: Jul 20 2007 Location: Canada Status: Offline Points: 1379 |
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Posted: Sep 04 2008 at 6:38pm |
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Dear Ang's Sister, A bisphosphonate will help so much with her pain....see if the doctor will put her on Zometa. Women with bone metastases get such good relief of the pain when they use a bisphosphonate and their regular pain medication. Maybe she could use a fentanyl patch....this is a patch that is put on once every 72 hours and gives good pain relief for chronic severe pain. I hope she gets relief soon. I do not know where she is being treated but have they tried Xeloda? You are very kind helping your sister. Connie
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