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Aspirin could beat cancer spread

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mindy555 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mindy555 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 26 2013 at 3:35pm
sabine-

I don't want to overlook the buffered aspirin vs. regular, even if it seems glaringly obvious.  I accidentally left my bottle of 81mg buffered aspirin at home on one of our out-of-town escapades.  Randy picked up an un-buffered low dose bottle for me.. probably because they were cheaper LOL

....and OMGOODNESS GRACIOUS.. I thought I was gonna die.  It tore up my stomach so badly!!!  I drank some green tea and thought I'd puke that up too.  I was miserable on that trip.. and quite dim.  It took me a few days to put 2 + 2 together and figure out the aspirin not being buffered was the relentless culprit.

Speaking of dim.. a few trips ago I forgot a bag containing all my makeup and toiletries.  At least I had my aspirin and supplements. Big smile
Dx July 2011 56 yo
Stage I IDC,TN,Grade 3
Grew to Stage IIa- No ev of node involve- BRCA1+ chondroid metaplasia
Daughter also BRCA1+
Mass grew on Taxol
FEC 6x better
BMX 3/19/12 pCR NED
BSO 6/2012
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Post Options Post Options   Thanks (0) Thanks(0)   Quote sabinecalifornia Quote  Post ReplyReply Direct Link To This Post Posted: Apr 30 2013 at 12:14pm
Mindy,
 
thank you for the advice. I will try the buffered Aspirin.
DX TNBC 7/11 @ age 50, Stage 2A Grade 3, 1/19, LE/AD 8/11, BRCA1/2 neg.,
4 A/C, 10 Taxol, 2 Abraxane due to allerg. react. to Taxol, fin 3/12. 33 Rads 6/12. NED CT 8/12, 10/13, 10/14
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 21 2014 at 6:59pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (1) Thanks(1)   Quote nancykind Quote  Post ReplyReply Direct Link To This Post Posted: May 23 2014 at 10:09pm
Originally posted by LRM216 LRM216 wrote:

If they said kitty litter would help, I'd be spooning that down too too!


LOL   that was great, thank you!! 
Lg lump never visible on any films but found 9mm. Lump 1/25/12, DX 1/31@50yrs IIIC/TN/DCIS/INV, Margins Unclr, Ki67 40%,Gr2. MX L 2/24. 3.1cm total. 11/17nodes. AC/T 2xWk,33rads. 12/12 MX R. 9/13 NED!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MomMom44 Quote  Post ReplyReply Direct Link To This Post Posted: May 24 2014 at 10:35am
Funny I just discussed this with my MO yesterday and told her I wasn't a candidate for 81 mg aspirin because when I tried it a few years back, I bruised very easily and stopped because I assumed it was thinning my blood out too much - internist agreed.  Maybe I should put up with thinner blood to gain this benefit???  Never had any stomach issues.  I'm on chemo now, but will reconsider and discuss with my MO again nearer end of treatment. 
DX TNBC 1/14; age 66; Stage 1; Grade 2; 1.2 cm; 0/2 nodes; lumpectomy; BRAC Neg; 4 DD AC; Completed 12 weekly Taxol July 2014; Radiation August 2014
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Post Options Post Options   Thanks (0) Thanks(0)   Quote sweetjam Quote  Post ReplyReply Direct Link To This Post Posted: May 24 2014 at 5:45pm
My onc said go ahead when I asked him about the baby aspirin. I hope I don't get it in the toe I broke 6 months before I was diagnosed. Haha.
DX 1/17/14 TN IDC, Stage 1 Grade 2, 1.4cm, Age 50, BRCA -, Started Chemo 2/10 C/T, every 3 weeks. Last Chemo 5/23/14. Double Mastectomy 6/23 3/4 nodes all negative. 6/23 final path tumor ER+, PR+,
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Aug 20 2019 at 8:30am

Association Between Aspirin and Mortality From Breast Cancer Depends on Patientís Genetic Profile

MedicalResearch.com Interview with:
Tengteng Wang, PhD, MSPH, MBBS
Postdoctoral Research Fellow
Department of Epidemiology
Harvard T.H. Chan School of Public Health
Channing Division of Network Medicine
Brigham and Womenís Hospital

MedicalResearch.com: What is the background for this study?

Response: Chronic inflammation is a key player in the development of multiple cancer types, including breast cancer. Aspirin is one of the major non-steroidal anti-inflammatory drugs (NSAIDs) which clearly has anti-inflammatory properties. Given this, substantial evidence from laboratory and population studies suggests that taking aspirin may reduce the risk of developing breast cancer. However, the association of aspirin use with death outcomes following breast cancer diagnosis remains inconclusive and inconsistent across studies.

Therefore, we choose to focus on mortality outcomes in this paper and we hypothesized that the inconsistent results for aspirin in relation to mortality could be due to differences in the association by patientsí biological profiles, specifically DNA methylation profiles here. 

MedicalResearch.com: What are the main findings? 

Response: Our most important findings suggest that the association between aspirin use and mortality following breast cancer diagnosis may depend upon patientsí DNA methylation profiles measured in the blood and tumor tissue. We observed that all-cause mortality after breast cancer was significantly elevated by 67% among aspirin ever-users with methylated tumor promotor of breast cancer gene 1 (BRCA1), but not those with unmethylated tumors. We also found that breast cancer-specific mortality was decreased by 40%, 20%, and 37%, respectively, among aspirin users with unmethylated tumor promotor of BRCA1 and progesterone receptor (PR) genes, and global hypermethylation of long interspersed elements-1 (LINE-1), but not those with methylated tumors and global hypomethylation of LINE-1.

MedicalResearch.com: What should readers take away from your report?

Response:  Aspirin use may have different influence on mortality outcomes after breast cancer diagnosis due to patientsí DNA methylations profiles measured in blood and breast tumor tissue. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response:  Future research designed to replicate our findings should include a larger sample size to allow examination of patterns and other time windows of aspirin use, and an enlarged panel of genes to explore the role of genetic predisposition in driving overall genetic instability on survival after breast cancer diagnosis.

https://medicalresearch.com/cancer-_-oncology/breast-cancer/association-between-aspirin-and-mortality-from-breast-cancer-depends-on-patients-genetic-profile/50913/

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Aug 20 2019 at 9:43am
Apparently there will be a clinical trial. These articles point to the complications that aren't understood yet of how much, when and what tumor characteristics will be affected.

https://stm.sciencemag.org/content/11/488/eaax1728
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Aug 20 2019 at 8:54pm
Thanks Mainy!  It sheds light to a more complicated subject than just a daily aspirin.

"Further studies will be needed to determine whether selective inhibition of platelets, COX-1, or thromboxane A2 can prevent metastasis. In this study, aspirin and inhibitors needed to be administered before tumor cells entered the bloodstream, making any intervention in patients more difficult. Also, higher concentrations of aspirin were required to reduce metastasis in the murine models but due to differences in species and bioavailability, these concentrations may not directly equate to the doses prescribed for patients. Low dose aspirin regimens carry bleeding risks and other potential side effects. A current phase III clinical trial, ADD-ASPIRIN, is underway to test whether an aspirin regimen after cancer diagnosis will prevent metastasis in patients with breast, colorectal, stomach, esophageal, or prostate cancers."
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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