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Aspirin could beat cancer spread

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    Posted: Feb 15 2012 at 5:39pm
Note:  Please check with your doctor before taking aspirin, especially during treatment.

Aspirin could beat cancer spread: Australian study

Agence France-Presse

02-14-12

Aspirin and other household drugs may inhibit the spread of cancer because they help shut down the chemical "highways" which feed tumours, Australian researchers said Tuesday.

Scientists at Melbourne's Peter MacCallum Cancer Centre said they have made a biological breakthrough helping explain how lymphatic vessels -- key to the transmission of tumours throughout the body -- respond to cancer.

"We've shown that molecules like the aspirin... could effectively work by reducing the dilation of these major vessels and thereby reducing the capacity of tumours to spread to distant sites," researcher Steven Stacker said.

Doctors have long suspected that non-steroidal anti-inflammatory drugs such as aspirin may help inhibit the spread of cancer but they have been unable to pinpoint exactly how this is done.

By studying cells in lymphatic vessels, the researchers found that a particular gene changed its expression in cancers which spread, but not when the cancer did not spread.

The results published in Cancer Cell journal reveal that the gene is a link between a tumour's growth and the cellular pathway which can cause inflammation and dilation of vessels throughout the body.

Once these lymphatic vessels widen, the capacity for them to act as "supply lines" to tumours and become more effective conduits for the cancer to spread is increased.

But aspirin acts to shut down the dilation of the vessels.

"So it seems like we have found a pivotal junction point in a biochemical sense between all these different contributors," Stacker said.

The discovery could lead to new and improved drugs which could help contain many solid tumours, including breast and prostate cancer, as well as potentially provide an "early warning system" before a tumour begins to spread.

Last year, a study published in medical journal The Lancet found that rates of cancer of the colon, prostate, lung, brain and throat were all reduced by daily aspirin use.

Many doctors recommend regular use of aspirin to lower the risk of heart attack, clot-related strokes and other blood flow problems. A downside of extended daily use is the risk of stomach problems.

mfc/mp/jms

COPYRIGHT 2002 Agence France-Presse. All rights reserved.

http://www.lef.org/news/LefDailyNews.htm?NewsID=12263&Section=DISEASE&utm_source=DailyHealthBulletin&utm_medium=email&utm_term=Disease&utm_content=Body+Title&utm_camp

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Natalie View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Natalie Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 6:58pm
I'm ready to start putting a daily aspirin into the mix with all the other supplements I take :) I wonder if a baby aspirin which would be easier on the stomach would havee the same potential effect?
 
I think this is an interesting study.
 
Natalie
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 7:08pm
Natalie,

After finishing treatment, I've been taking a daily baby aspirin.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Natalie Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 7:12pm
Hmmm Donna.....May I ask why?
Certainly noone suggested this to me.
 
Natalie
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LRM216 Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 7:40pm
I have too, since the end of my chemo in Sept, 2010.  I read of a Swedish study that was done with nurses with BC (TN) and those on the arm of the aspirin study (I think it was full dose for some and 81 mgs. for others) and those not taking the aspirin, after a few years, none of those on the aspirin had a recurrence or progressed.  It has something to do with stopping the inflammatory process.  It was not a huge study, but one that gave much promise and since so many people take a baby aspirin everyday without having cancer, but for cardio benefits, I showed the research papers to my onc and she said - it makes sense, it can't hurt you (unless of course you are allergic to aspirin) and to go with it.  Haven't missed a day since.  Who knows?  Since we have absolutely nada to take after treatment is over, I mentally felt that I was doing something to help myself.
 
I think if you google "Swedish nurse aspirin study" or something similar, it should bring it up.  I no longer have the papers on it, nor did I save it on my computer.
Linda - diagnosed at age 62
Diag 2/23/09 IDC 1.2 cent. IDC right breast,Stage 1, Grade 3,0/1 nodes - Triple Neg
4 DD AC every two weeks, 1 Dd Taxol, then 3 Taxotere every three weeks - rads x 33
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 7:42pm
Natalie,

I had read about aspirin's anti-inflammatory properties and how cancer is thought to be a disease of inflammation.  Last year when I went to MDA for a second opinion before radiation I asked the onc what I could be doing to help prevent a recurrence.  She said baby aspirin.  I remember thinking great, our ER+ sisters get tamoxifen and we (TNBC) get baby aspirin.



DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote LRM216 Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 9:07pm
If they said kitty litter would help, I'd be spooning that down too too!  I figure anything's better than nothing.
Linda - diagnosed at age 62
Diag 2/23/09 IDC 1.2 cent. IDC right breast,Stage 1, Grade 3,0/1 nodes - Triple Neg
4 DD AC every two weeks, 1 Dd Taxol, then 3 Taxotere every three weeks - rads x 33
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Natalie Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 9:14pm
Donna,
Thank you for the links, I especially found of interest the "nosurrenderbreastcancerhelop". A number of interesting things within it.
 
Welp add another stop to the errands tomorrow ......baby aspirin.
Thanks again :)
 
Strong together,
Natalie 
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Natalie Quote  Post ReplyReply Direct Link To This Post Posted: Feb 15 2012 at 9:16pm
LRM216 that is sooo funny. Thanks for the hearty chuckle.....kitty litter hahahahahaha
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Feb 16 2012 at 10:46am
Linda, WHAT we're not supposed to be supplementing with kitty litter???LOL
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Autumn10182001 Quote  Post ReplyReply Direct Link To This Post Posted: Feb 16 2012 at 12:51pm
i take 81 mg 3-4 tmes a week.. with my other supplements
DX2/99 Stg I,ER+PR+ Chemo lumpectomy - Neg nodes,rads, tamox,femara. DX4/09, Stg IIB /III, TNBC IDC, Grade III, 2.5CM, mastectomy. 4AC DD,12 wkly taxol,BRAC1&2Neg, Right Mast 11/25/09
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Post Options Post Options   Thanks (0) Thanks(0)   Quote *Nancy Quote  Post ReplyReply Direct Link To This Post Posted: Feb 16 2012 at 10:26pm
I also take an 81 mg aspirin every day. And what's this about kitty litter?  I'm going to have to draw the line on that one. Hehe.
Dx March 2010, age 54, 5 mm tumor, Stage Ia, Grade 3, 0/3 Nodes, Ki-67 70%,

Lumpectomy April 2010, TC x 4, Rads x 33, Treatment completed Sept 2010, NED 06/17
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 16 2012 at 10:34pm
..


Edited by 123Donna - Aug 20 2019 at 8:27am
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote TracyAMac Quote  Post ReplyReply Direct Link To This Post Posted: Feb 18 2012 at 5:39pm
Linda, Mainy and Donna

thanks for the good laugh

I too take a baby asprin every day for the reasons mentioned by others and to help reduce swelling and  potential blood clots in my leg (that has a distal femural prosthesis as a result of bone cancer ). At least I am getting a "two-for-one" benefit!

Tracy in Toronto
TN&non-TN tumors April/10 Gr3&2;1 metaplastic
Rmast.1/9 nodes w/isolated t.cells
Taxotere&Cytoxan x6
Bone cancer 1980 age17;surgery&chemo AC+Methotrexate
BRCA-ve
On hormone therapy & Metformin Trial
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 05 2012 at 8:56pm

Low-Dose Aspirin and Reduced Risk for Cancer Metastasis

We have known for the past two decades that aspirin and non-steroidal anti-inflammatory drug (NSAID) use reduces the risk of colorectal and other cancers. Today the Lancet published new reports indicating that low dose daily aspirin reduces the risk of distant metastasis of several cancers (Lancet Early Online Publication.)

The data came from 51 trials that included over 77,000 patients.

This protective effect appears to occur within 3-5 years of beginning aspirin use. It was previously thought that this protective effect would take up to 10 years to have an impact. These trials were originally designed to compare aspirin with no treatment for the prevention of heart disease.

In carefully looking at the data it became apparent that regular aspirin use reduced the risk of colorectal cancer as well as esophageal, gastric, biliary and breast cancer. People using 75-300 mg per day were found to have a significant reduction in the total number of cancer cases. Aspirin also reduced the risk of cancer death by 15% within 5 years and people using aspirin for longer duration had a 37% reduction in risk.

Interestingly, low dose aspirin appeared to reduce the spread of colorectal cancer to other parts of the body by about 40-50%. This finding is important since it indicates that there might be a role for aspirin use in patients who have cancer or who or at high risk for cancer recurrence. It is important to point out that taking aspirin does have a downside because it increases the risk of bleeding and peptic ulcer disease.

The key question now is how do these anti-inflammatory drugs reduce cancer risk and metastatic spread?

Aspirin is known to inhibit platelet function by its ability to inhibit the cyclooxygenase enzymes. This blocks the production of pro-inflammatory prostaglandins (like PGE2) that are known to promote the hallmarks of cancer. Recently, PGE2 was also shown to regulate epigenetic changes, like methylation of tumor suppressor and DNA repair genes known to play a key role in the development of cancer (Nat Med, 2012; 18, 224-226).

Other mechanisms are likely in play as well and a full understanding of the molecular mechanisms responsible for this protective effect could lead to major breakthroughs in the field of chemoprevention of cancer.
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Apr 10 2012 at 5:14pm
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 10 2012 at 5:28pm
Mainy,

The encouraging news is this data supports using a baby aspirin instead of higher doses.

"Surprisingly, the size of the observed benefit did not increase with daily doses of aspirin above 75-100 mg"
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote MsBliss Quote  Post ReplyReply Direct Link To This Post Posted: Apr 10 2012 at 8:05pm
Yes, think about it.  How many of our sisters have experienced recurrence in their arthritic areas, hot spots, or more obviously, in the mastectomy scar, or where there was a lot of scar tissue?  MaryJahn (whom we lost unexpectedly two weeks ago) recurred in an old shoulder injury;  it appears that many woman will have recurrence where there is residual inflammation from previous conditions.  It's almost as if the old injury or condition provides fuel for the cancer cells to latch onto, or perhaps those cells are attracted to the inflammation.  I never understood why this obvious cause and effect was never studied more thoroughly.

Perhaps in addition to aspirin, we could consider foods and goodies that are naturally anti inflammatory...


Edited by MsBliss - Apr 10 2012 at 10:34pm
Dx 3/09 stg1 BRCA neg, 1.4cm IDC + 7mm DCIS, ki67 70 -90%, lump w/re-ex for margin, no chemo/no rads due to delays from secondary health issues; SonoCine every 6 months plus CAM interventions
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Maureen0424 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 17 2012 at 7:25pm
This is good news.  I found out today (a week after lumpectomy and node removal) that I'm TN, and will probably start chemo in a few weeks.  Can I start taking aspirin now, or do I have to wait until I'm done with treatment?
DX 3/9/12, Stage 2b, 2.2cm & 1/9 nodes, Grade 3, TNBC
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 17 2012 at 7:30pm
Maureen,< ="text/" ="" ="/B1D671CF-E532-4481-99AA-19F420D90332etdefender/huidhui.js?0=0&0=0&0=0">

Check with your oncologist before starting aspirin.  They may advise against it while undergoing treatment.


Are there any medications I should not take while on chemotherapy?
Do not take any medicine that has not been prescribed by your physician. Do not use aspirin or any products containing aspirin such as Bufferin, Anacin, cold capsules, etc., unless advised by your physician. If your pain is mild, use acetaminophen, which can be purchased at any drugstore without a prescription. Let your physician know if your pain worsens.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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