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Adriamycin Not Good for TNBC

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Cebo View Drop Down
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    Posted: May 15 2009 at 7:39pm
Does the medical community know anything about how to treat this disease?  With all this bad news the past few days (e.g., chemo doesn't help majority of TNBC), I am really beginning to think this is all a big fat crap shoot.

Not feeling very hopeful tonight.  Any chance any expert on the TNBC board could post on these 2 very significant pieces of information?  
Sister DX'ed 11/08
Lumpectomy & SN biopsy 12/08
1.1 cm tumor, node neg (0/2)
Stage 1
DD A/C x 4, Taxol x 4, completed 4/17/09
33 rads (incl 8 boost), completed 6/22/09
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Sunris Quote  Post ReplyReply Direct Link To This Post Posted: May 15 2009 at 7:53pm
My original understanding is that chemo DOES respond better to TNBC quite well.....but geez....do I know what to believe anymore ?? Nope...sure don't...it's getting frustrating.
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NINASUZIE View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote NINASUZIE Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 5:05am
Hi,
 
I am in need of the links for the articles you are referring to as there are several threads going at the same time with good issues.  I would like to get the input you ask for from good experts that way...Wink
Suzie
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Dx: 1/09 Metaplastic TN IDC/3.5CM/DCIS/1.0;4/09 L mastectomy;6-11/09 Cytoxan/Taxotere X6;BRACA-; Recurrance 11/10 bone mets broke arm;Lung mets;rads X15; chemo/parp tbd 1/11
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Nancy View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Nancy Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 6:51am
Suzie,
 
To which articles are you referring? I can do a search. Pam posted one yesterday and so did Ac and JC. Then we have many which state that TNBC does respond very well to chemo, and they are mostly from doctors on the breast cancer sites.
Nancy
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DD Lori dx TNBC June 13,2007
Lumpectomy due to incorrect dx of a cyst
mastectomy July 6 2007
chemo ACT all 3 every 3 weeks 6 tx Aug-Nov
28 rads ended Jan 2008
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Cebo Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 7:10am
Yes, I was referring to this article Pam posted

I know it is just one study, but following on the heels of the Emory Univ. Prof who said most TNBC does not respond well to chemo, it is discouraging info to say the least
Sister DX'ed 11/08
Lumpectomy & SN biopsy 12/08
1.1 cm tumor, node neg (0/2)
Stage 1
DD A/C x 4, Taxol x 4, completed 4/17/09
33 rads (incl 8 boost), completed 6/22/09
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NINASUZIE View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote NINASUZIE Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 7:18am
Nancy,
 
The 2 pieces Cebo was referring to-maybe the Emory dr and the Adria perhaps?  Maybe she could clarify which 2 pieces she was referring to?
And thank you for the research helpWink   Hugs,
Suzie
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Dx: 1/09 Metaplastic TN IDC/3.5CM/DCIS/1.0;4/09 L mastectomy;6-11/09 Cytoxan/Taxotere X6;BRACA-; Recurrance 11/10 bone mets broke arm;Lung mets;rads X15; chemo/parp tbd 1/11
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Nancy Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 8:01am
Cebo,
 
Doesn't this just want to make you bang your head into a wall? Lori had ACT and that was 2 years ago, and I continue to read this was/is a very effective chemo...but....I also know that is the same regimen given to BC+, so where is the difference in treaments for TNBC? They just do not know, plain and simple.
 
Many continue to discredit the antiaging specialists, of which many are scientists, and anthropologists, immunologists and of course licensed MD's, and a few of them have stated that once you have cancer you will always have cancer. A woman was dx with bc in her 60's and the day before she died at 90, they discovered cancer at the site of the incision of her mastectomy. Had she died a day earlier, she would have been considered cured. There is no cure for cancer, and Lori has accepted that fact, but is doing her best to find alternate treatments to keep the healthy cells active to fight those which have or may mutate.
 
Pam posted the credentials for this doctor in the article which you posted again, and they are very impressive, and the question is...what does she know that others do not? They cannot come to a consensus and until all people dx with cancer demand a cure, it will remain staus quo. How can 185,000 women be dx with bc here in the states alone every year? Something is terribly wrong, and we have foods that are genetically modified, toxins in our water, and poisons in our environment, and we sit idly by and accept this?
Hugs,
Nancy
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DD Lori dx TNBC June 13,2007
Lumpectomy due to incorrect dx of a cyst
mastectomy July 6 2007
chemo ACT all 3 every 3 weeks 6 tx Aug-Nov
28 rads ended Jan 2008
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mefowler Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 1:23pm

There is a big difference in breast cancer in older women and younger women.  Many believe that breast cancer in older women is like prostate cancer in older men, it is much less aggressive and is unlikely to result in death.   I know of women who developed breast cancer in their eighties and lived with no treatment for more than ten years, dying of other causes.  Breast cancer in younger women tends to much more aggressive, also like prostate cancer in younger men.  Triple negative cancer is more common in younger women and more aggressive.  I believe the biggest problem is that different people respond to different medications.  Just as some antidepressants work for some people, and others do not respond to them at all, but do respond to other medications, it is the same thing with chemotherapy.  All the time, scientists are learning more information about genetic markers that can predict responses, but for every marker that has been identified, there are probably hundreds that are completely unknown.  I sometimes think of that early Star Trek movie where they come back to the twentieth century and Bones sees the woman waiting for dialysis and mutters "barbarians" before curing her with his handheld medical unit.  I am sure that in 100 years, people will look at our current medical treatments the same way.  But each of us is helping contribute to medical knowledge and hopefully helping ensure that women with breast cancer in the future receive better treatment than we did.

Of course that's just my opinion, I could have my head where only my proctologist could find it!
 
Maire
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Nancy Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 2:41pm
Hi Marie,
 
When I wrote about antiaging specialists, that does not refer to just the elderly. This is a completely different way to treat everyone from a very young person to those in their golden years, and is done with biodentical hormones. Not just for estrogen, progesterone and testosterone but for people with allergies and immune defieciencies, asthma, and many other illnesses.
 
As I wrote in a few other posts, Lori will be taking the biodenticals and so will her husband. He has severe allergies and arthritis and has had a knee replacement, so is dealing with a multitude of problems. 
 
I know that the medical profession has not yet identified even 1/100th of the genetic markers, and yet billions of dollars has been spent for research, and they are not looking for a cause, just more treatments. They still do not have a clue as to why millions are dx with cancer every year. It was not this way before 1940.
 
I too wish that we could fast forward to the year 2121 and see if they found the cause and cancer has been eradicated. If they keep throwing the money where they are now, we will not be any further ahead, and the population will have dwindled. Sadly, it will be the population of women. We are not seeing less women dx with bc, we are seeing more, and it is an epidemic of enormous proportions.
 
It's not that the scientists do not want to find the cause or the cure, it is a known fact that most of the research is funded by the drug companies. I also find it very disturbing that many of the illnesses are not responding to the antibiotics currently in use, so they have to continue to develop more.
 
We have the sickest women on the face of the earth right here in the US so what in the world is going on? People need to look beyond ensuring that women with breast cancer receive better treatment in the future, and look as to what is causing the breast cancer.
 
Yes Marie, my Lori and you and Pam and Donna and Connie and all of the women dx with bc are contributing to medical knowledge, but sadly and tragically, many are doing so with their lives. Over 44,000 every year to be exact.
 
I didn't give birth to my beautiful, loving, compassionate, intelligent brown eyed daughter to have her used as a lab rat for a drug company and for all the investors to get filthy rich from her suffering, and have poison infused in her body, and still not know if the cancer cells were killed.
 
Now we have a 10 year old little girl dx with TNBC....something is very very wrong somewhere, and this is not genetics.  
 
Many hugs,
Nancy
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DD Lori dx TNBC June 13,2007
Lumpectomy due to incorrect dx of a cyst
mastectomy July 6 2007
chemo ACT all 3 every 3 weeks 6 tx Aug-Nov
28 rads ended Jan 2008
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Post Options Post Options   Thanks (0) Thanks(0)   Quote JanetK Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2009 at 4:48pm
There are so very many articles out there that support chemo is indeed the best way to go with TNBC. I have been reading nonstop since I have been DX on Feb 13, this year.I am on a clinical trial that is using an already known drug that helps mets BC (Avastin) NSABP Protocol B-40 randomized 1B.I have decided to do neo adjuvant chemo and lumpectomy. I had my third chemo yesterday and my palpable lump has shrunk 25% and has almost broken in two peices! So, apparently this is working for me.
TNBC feb 13,2009
2.6x 3.5
neoadjuvant chemo 8 rounds
Lumpectomy successful Oct 09
axillary node dissection Nov 09
still awaiting results
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