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2nd opinion : Olopade / Genetic counseling

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Eric View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Eric Quote  Post ReplyReply Direct Link To This Post Topic: 2nd opinion : Olopade / Genetic counseling
    Posted: Oct 06 2008 at 6:09am
We are visiting Chicago later this week, and are considering a second opinion at Univ of Chicago. When we were making a decision about choosing a chemo regimen in July, the onc here, at Univ of Iowa, was recommending adriamycin/cytoxin. After finding that Funmi Olopade at Univ of Chicago was an authority on TNBC, we contacted her to see what chemo she would recommend. She very helpfully gave us a couple of options, one of which was Taxotere+Cytoxan, which we eventually chose, and neither of her options included adriamycin. We had the TC option confirmed by another email consult, so we chose that ...

Unfortunately we were told last week that Dr Olopade is not currently seeing new patients. So we're wondering whether it would be useful to see one of the other onc's in the dept there, who has less experience with TNBC. Does anyone have experience at Univ of Chicago?

We're also considering an appt at Univ of Chicago with a genetic counselor to talk about TNBC -- Have people found genetic counseling  helpful?


Eric for Christine
dx 5/23/08 IDC TNBC CK5/6+ basal-like?
Stage 1 Grade 3 1.2 cm clear margins
Lump+SNB Node 6/9/08
chemo Taxotere+ Cytoxan 4x3 wks 7/15/08-9/18/08
35 rads start ~10/13/08
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CarynRose View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote CarynRose Quote  Post ReplyReply Direct Link To This Post Posted: Oct 06 2008 at 7:49am
I can't speak on U of Chicago, but I can tell you that for someone with TNBC, genetic counseling is very important because certain genetic mutations (BRCA1, for instance) tend to cause breast cancers that are triple negative.  Decisions on how to procede if there is a genetic mutation would vary from if there weren't one and a genetic counselor would be ther expert to see for that.
 
All the best,
Caryn
Orig dx 6/03 - St.2a, IDC
gr.3,0 nodes, TNBC/BRCA1+
7/07 St 4 mets to nodes/lungs. PACA/Rads NED 11/07-10/08
Lepto mets 10/08
Rads for 4 brain tumors 4/10.
Leptomets return 6/10
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sibu View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote sibu Quote  Post ReplyReply Direct Link To This Post Posted: Oct 06 2008 at 3:13pm
Hi Eric, I'm going to give you a VERY shorthand response here, which in no way should be taken as valid medical advice. ;)

It seems almost unanimously on this board, those who have done chemo recently, have done a variation on TAC. Most commonly, either 6 treatments every three weeks of all three at once, or the AC first, with a series of T weekly afterward (this seems to be the latest trend?). It doesn't seem to me that there are many dissenting opinions for triple negatives.

Very best to you and your wife in navigating all of this.


Donna, age 42
Dx IDC 12/06, 5/18 Nodes + BRCA1+
Double mast. 1/07
Chemo 6 X TAC 6/07, rads 10/07
Hyst./Recon. 12/07
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Post Options Post Options   Thanks (0) Thanks(0)   Quote trip2 Quote  Post ReplyReply Direct Link To This Post Posted: Oct 06 2008 at 3:49pm
Eric,
 
I second CarynRose's comments about genetic counseling.
 
 
The meds you mention sound like they are right on with most of the rest of the gals here.
 
There is some debate between researcher's regarding Adriamycin.
A report came out a bit ago saying that only 8% of triple negs would benefit from A.
Also it holds a risk of CHP for the patient.  My Onc claimed he stayed below the line on dosage but I did end up with CHP 4 yrs after taking it.
 
 
 
Stage 2 2003
Stage 1 2007
BRCA 1+
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AustinCarol View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote AustinCarol Quote  Post ReplyReply Direct Link To This Post Posted: Oct 06 2008 at 6:22pm
Eric,

If Christine knows of any blood relatives with breast cancer or ovarian cancer, she should have genetic counseling. My mother had breast cancer twice (in her 70's 6 years apart) and her sister died of ovarian before I was born. I had the BRCA testing, but ended up negative to the gene thankfully. But it was good to understand the choics to consider and that is what the counselor helped with. She was a nurse specialist. I would think you could get counseling locally too.

-Carol

Dx 01/06 DCIS LB (age 47) TN Stage 2a; High grade; MBRS 9/9; 4 cm; nodes neg; BRCA-
Tx neoadjuvant AC4 + T4 dose dense; Lump 06/06; 35 rads (7 boosts) 08/06
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Post Options Post Options   Thanks (0) Thanks(0)   Quote NancyJane Quote  Post ReplyReply Direct Link To This Post Posted: Oct 07 2008 at 4:38am
I believe knowledge is power.  If you have any family history of breast, ovarian or cancer in the falopian tubes, I would consider genetic counseling.  My Mother and Maternal Grandmother both died of ovarian/breast cancer.  Having the genetic counseling helped me understand exactly what the BRCA gene mutation meant to me.  It changed how I approached treatment/surgery options.  If you have the mutation, your cancer is not random or sporadic.  It is genetically ordained, and will more than likely happen again.  The statistics are stagering.  If found the information empowering.
41yr dx 7/25/08
Lumpectomy and ax node disection (38 nodes, all clean!) 8/12/08
T2 grd 3, N0, TN IDC
BRCA1+
ACx4,Tx12 10/08-3/09
prophylactic hyst, ooph,mast & one-step recon 3/30/09
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