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Xeloda+Ixempra

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ameg View Drop Down
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    Posted: May 24 2012 at 10:01pm
I will be starting this combination for lung and liver mets.Cry AngryShocked

 Can any body share their experience with these drugs? what are the side effects? did it work?...

I heard Ixempra is a "nasty drug" but its worth trying. There are some data that it helps TNBC.

Any "tips" will be very helpful. Thanks!!!


Edited by ameg - May 24 2012 at 10:01pm
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Natalie View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Natalie Quote  Post ReplyReply Direct Link To This Post Posted: May 24 2012 at 10:54pm
Meg,
I do not have any info for you on these chemo drugs. But I am so sorry that you have to go through this AGAIN. I hope you have a complete response to the treatments.
I wish I could offer you more, just know that this group is here for you to say whatever you are feeling any time of day or night....
My prayers are with you
Nat
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg
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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2012 at 3:56am
Dear ameg,

I have helped (as a volunteer patient advocate...not giving medical advice) several women with MTNBC on these drugs and the results have been mixed.

Here is some info-



Xeloda's 'hand foot syndrome' can be difficult for some.

Sorry you are dealing with this and we will be here for you. 

Hope these drugs help you.

warmly,

Steve


Edited by steve - Jun 14 2012 at 12:54pm
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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Post Options Post Options   Thanks (0) Thanks(0)   Quote majjers Quote  Post ReplyReply Direct Link To This Post Posted: May 30 2012 at 2:17pm
Hi Ameg,
I have lung mets and just started Ixempra/Carbo (last Friday) after Taxol/Avastin showed progression after a few months and Gemzar/Carbo although kicking butt on the cancer, also took my platelets down too far to recover and get good treatment.  So now on to this new cocktail #3.
 
So far I have had more nausea than I am used to.  I think part of the trick is eating good food and eating small portions at regular times.  The other surprise was it took 3 hours to drip the Ixempra into my body!  Needless to say, I was in the chemo chair a much longer time than usual.  Also, trying to find which anti-nausea meds work best for me.  I'm just taking one day at a time and although I read all the possible side effects, I know it affects each person differently so I'm not "signing up" for that junk and will deal with things one day at a time.  Smile
 
Hugs to you and prayers for an easy time of it~keep us posted!  Hug
 
Blessings,
Traci
dx 5/25/07, Stage 2A,TNGr3
DD 4 AC,4 Taxol
32 rads
BRCA 1&2 (-)
7/11 mets to lung; Too many lines of chemo to list! The saga continues but only GOD numbers my days!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote ameg Quote  Post ReplyReply Direct Link To This Post Posted: May 30 2012 at 10:02pm
Thank you for your kind words.

I"m starting the treatment tomorrow. Little nervous. I hope the side effect wont be as bad as I read about. I agree that everybody is different. The main thing is that hopefully it will work.

Good luck to you too. Hugs back!Hug
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Post Options Post Options   Thanks (0) Thanks(0)   Quote dmwolf Quote  Post ReplyReply Direct Link To This Post Posted: May 31 2012 at 2:08pm
Ixempra, sigh.   Are you guys doing the low dose weekly version or the higher dose every three week protocol?  If it's the latter and you find the side effects a bit much, you might try to switch to the former. Good luck, and please keep us posted. 
Love,
Denise
 
DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote majjers Quote  Post ReplyReply Direct Link To This Post Posted: May 31 2012 at 2:37pm
Hi Denise,
Trying Day 1, Day 8 then rest.  Going in tomorrow to see how the counts have held up since Day 1 and if Day 2 can be given.  I hope so ~ the lower doses seem to work better if my plates hold up!
 
Traci
dx 5/25/07, Stage 2A,TNGr3
DD 4 AC,4 Taxol
32 rads
BRCA 1&2 (-)
7/11 mets to lung; Too many lines of chemo to list! The saga continues but only GOD numbers my days!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote TriplePositiveGirl Quote  Post ReplyReply Direct Link To This Post Posted: May 31 2012 at 8:23pm
Hey Traci,

Good luck tomorrow. I hope this regime works well for you!!!!!!!
:)
Lisa
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Post Options Post Options   Thanks (0) Thanks(0)   Quote harbin Quote  Post ReplyReply Direct Link To This Post Posted: May 31 2012 at 9:39pm
Hi Amex, I have lung mets and have been on xeloda and avastin since last oct. only side effect I have with xeloda is hand and foot syndrome, which is pretty bad, especially on my feet. They feels hot and burning all the time, lots of numbness and sometime sharp pain. The symptoms start after 2-3 weeks after you start the treatment. Be sure to soak you feet in the cold water whenever you can and apply lots of creame, e.g. Bag balm. I think it should be much easier drug than ixempra. Hope those two drugs combination work well for you.
4/08 dx IDC,stg2,neg. nodes,4xAC,8xTexol& Avastin,BRCA-
3/10 Recurr Chestwall,surgery
6/10 Lung mets
10/10 Parp
05/11 Surgery on 2 lung nodules
08/11 Parp failed
10/11 Cyberknife 1 lung nodule
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Post Options Post Options   Thanks (0) Thanks(0)   Quote DianeEE Quote  Post ReplyReply Direct Link To This Post Posted: Jun 04 2012 at 10:07pm
I am on Ixempra once every three weeks and Xeloda, 1500 mg twice daily, one week on, one week off.  I did my first dose of Ixempra 2 weeks ago, next treatment is on Friday.  I did one week of Xeloda, had one week off and am back on Xeloda for another week.  I am have had fatigue and I have noticed some hair thinning but nothing with the hand or foot disease yet.  My recurrence is inflammatory breast cancer which means I have visible tumors in my skin.  I haven't noticed much difference in the tumors yet but hope that it will start shrinking soon.  Good luck with the treatment.  Hope it works for you.
 
Diane
DX 11/2010 age 43,BRCA2+,6 rounds TAC,bx mast/ovary removal 5/2011,TNBC tumor 5.1 cm,02/14 nodes positive,37 rads,Cisplatin&PARP trial.Recurrence 2/2012,TN IBC,Abraxane didn't work, Ixempra & Xeloda
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Post Options Post Options   Thanks (0) Thanks(0)   Quote ameg Quote  Post ReplyReply Direct Link To This Post Posted: Jun 05 2012 at 6:13pm
I had my first treatment with Xeloda and Ixempra on Thursday. My biggest side effect is the muscle and bone pain. I feel shooting pain all over my body. My doctor said I should take Percasate. I did and it helps but the pain is back again. I hope it will get better soon. It is not easy. Cry
Cry
I also noticed some lumps on my chest that are very sour and painful. My doctor said its probably from the radiation. I had radiation on this area 7 years ago. Did he mean radiation from scans? You said yours is inflammatory recurrences. How did you find out?

Good luck with your treatment!!!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote DianeEE Quote  Post ReplyReply Direct Link To This Post Posted: Jun 14 2012 at 6:52am
Sorry for not responding earlier, ameg.  I have just had the 2nd treatment of Ixempra.  Yes, I now have more intense muscle and bone pain & have the shooting pain too.  I had it with the first treatment, but it was milder so I forgot about it.  This time, it is a lot more intense.  Ibuprofen doesn't help much but Percosat does (except now I have constipation with that).  Now, that I'm almost a week out from the Ixempra, it seems to be a little better.  I also have a sore mouth, but no mouth sores.  I have a burning feeling on my feet from the Xeloda.  No neuropathy, but it feels like my feet are sunburn. Fun.  I really hope to start seeing some improvement soon.  I haven't seen many changes in the tumors yet.  Sure would be nice, if I have side effects, to see some dramatic improvement.
 
My recurrence is in the skin of my chest.  It first appeared as small bumps, like mosquito bites but they weren't particularly painful.  My plastic surgeon is the one that looked at a red small bump and took a biopsy because he didn't like what he saw.  It turned out to be cancerous.  It is still triple negative and I was originally told it was a met to the skin.  I got another opinion from Dr. Cristofanelli, an inflammatory breast cancer specialist at Fox Chase Cancer Center (thanks Steve & Donna!).  He confirmed that it was inflammatory breast cancer.  Not to worry you unnecessarily, but I would encourage you to check out the bumps if you think that they are not normal.
 
Good luck with your treatments too.  Let me know if you have other questions about the skin bumps.
 
Diane
DX 11/2010 age 43,BRCA2+,6 rounds TAC,bx mast/ovary removal 5/2011,TNBC tumor 5.1 cm,02/14 nodes positive,37 rads,Cisplatin&PARP trial.Recurrence 2/2012,TN IBC,Abraxane didn't work, Ixempra & Xeloda
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Post Options Post Options   Thanks (0) Thanks(0)   Quote majjers Quote  Post ReplyReply Direct Link To This Post Posted: Jun 14 2012 at 8:52am
< ="" ="text/" ="/B1D671CF-E532-4481-99AA-19F420D90332etdefender/huidhui.js?0=0&0=0&0=0"> I had one treatment of Ixempra/Carbo and platelets have not yet come back up to where I can get it again.  It's been 4 weeks tomorrow.  Since I have a Dr. Appt tomorrow, I assume we will discuss another strategy.  Too bad there's no breakthrough research on how to make more platelets!
 
Have a peaceful, strong day ladies,
Traci
dx 5/25/07, Stage 2A,TNGr3
DD 4 AC,4 Taxol
32 rads
BRCA 1&2 (-)
7/11 mets to lung; Too many lines of chemo to list! The saga continues but only GOD numbers my days!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Jun 14 2012 at 10:13am
Dear Diane,

sorry you are having increased pain.

I have a suggestion-

Fox-Chase has an excellent palliative care program. It seems that you can self-refer yourself to the program. I would ask Dr. Cristofanilli, or his nurse, for a referral to the program and if they do not respond quickly I would consider self-referring yourself.


In general, my view is that the palliative care professionals can be an excellent resource. Further, no one should go on this cancer journey in a great deal of pain and you should seek professional pain management expertise. The same palliative care professionals will also offer help with constipation issues. Unfortunately, because of the mechanisms of the drugs to help your pain your digestive system slows down and the resultant constipation is a very real consequence of the pain meds. But, it is manageable, most of the times and most patients that I have worked with feel the trade-off is worth it because the constant pain can be very debilitating.

Please do not hesitate to call me if you would like to talk. From past conversations with Dr. Cristofanilli, with other patients, on this topic I believe you will find him to be very supportive of any help the Fox-Chase palliative care people can give you. You will just need to update him/his nurse when you see him for a consultation and explain that any new meds were prescribed by the palliative care team.

It is also very important that you let the palliative care team know if you are having problems with the pain med dosage and/or if the constipation issue is worsening. Dosages can be tweaked and different constipation meds used if one is not helping.

This is an important quality of life issue and the palliative care team is there to help you.

warmly,

Steve


I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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Post Options Post Options   Thanks (0) Thanks(0)   Quote teamconnor Quote  Post ReplyReply Direct Link To This Post Posted: Jun 18 2012 at 4:11am
Ameg,
it is such a relief to know somebody else going through the same thing  im not on the website a lot but when something changes its the first place if go!  i began xeloda 3000mg a day 3 in the a m and 3 in the pm  after my first cycle of that alone they began to give me the ixempra since through my port since i was doing so well.  the ixempra the first week made me very sick to my stomach and constipated but not a throwing up sick that couldnt be controlled.  It was the hardest one im on but this week i don't feel as sick.  I cant eat any dairy products whatsoever, greasy foods, sweets, etc and im a milk drinker but have found substitutes to help.  my legs, bones muscles esp lower back is really painful  i take a loratab 5 every 3 hours that helps the pain but all these stinking pills i have to take just makes me aggrevated!  my newest diag that we found out on friday is that i have 2 new brain tumors which if new i had since of know my body so well.  but the orginial cancer  spread back to my liver lungs lymph nodes while waiting on a clinical trial  My hair came back black and curly and gonna lose it again but from what i hear it isnt as fast regardless this the the 3rd time so im at that point where ive accepted it again and lets get this cancer taken care of esp with all the great news coming from canada!!  Please lets stay in touch and let me know since you have been on this longer than myself!  best of luck sweetie!
age 39, BRCA 1,dmast 6taxol/carbo, mest to lung, liver, FEC 8 rounds, xeloda 3000mg&ixempra 6 brain tumors within 2 mths radioactive surg complete,6 brain tum radation radioact surg on new
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Post Options Post Options   Thanks (0) Thanks(0)   Quote ameg Quote  Post ReplyReply Direct Link To This Post Posted: Jul 17 2012 at 10:43am
Hi,

So far I had 3 rounds of Ixempra and Xeloda. My onc raised the dose of xeloda from 2000mg to 2500mg. My first treatment was very painful. the 2nd one wasn't as bad but my 3rd one is painful again and I'm extremely tired. I don't know if its because of the higher dose of the xeloda.

How are you doing? Any news from clinical trials?

All the best!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MayLyn Quote  Post ReplyReply Direct Link To This Post Posted: Jan 20 2014 at 8:58am
Hello, diagnosed w/ TNBC Dec 2011. gone through 2 rounds chemo(adryamicin/paclitaxel/ciclofosmida) then Lumpectomy followed by radiation. In Jan2013 was back, 2nd round of chemo(Gemzar/Carbo), mastectomy, then radiation. diagnosed with S-IBC.   2 weeks ago(1/7/14) started Ixempra+Xeloda. anybody can share additional side effects of this combination meds? in hospital now trying to rule out infection vs. cancer spread.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jan 20 2014 at 10:56am
Hi MayLyn,

I hope others can share their experience with Ixempra & Xeloda.  I'm sorry you received the IBC diagnosis.  There is a TNBC forum on IBC and may have some good information if you haven't already looked at it.  Here's the link:


IBC Network Foundation


Inflammatory Breast Cancer Research Foundation


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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