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Xeloda & 5-fluorouracil

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rstar View Drop Down
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    Posted: Apr 17 2017 at 5:02am
Hi there,

My mom was treated with the standard neoadjuvant AC+T & also received 5-fu as part of her CMF adjuvant regimen. 6 months later she recurred with lung mets and after a whole year on a parp trial, the oncologist put her on xeloda. Here is my question.. Isn't xeloda and 5-fu the same? Doesn't she basically put her back on a drug that she already progressed on since it didn't prevent the mets?


Edited by rstar - Apr 17 2017 at 5:16am
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gordon15 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 17 2017 at 4:31pm
I don't know your answer but I would ask the same question directly to her oncologist, email it to him/her in writing if needbe, and save a copy.
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 18 2017 at 11:02pm
rstar,

Good question and probably one to ask your mother's oncologist.  I found this description of the two:
"Capecitabine is a rationally designed 5-FU pro-drug developed to mimic the continuous infusion of 5-FU while avoiding complications and inconvenience of intravenous administration. Capecitabine is absorbed intact from the gastrointestinal tract, converted enzymatically to active 5-FU, and released directly into the tumor. "
http://link.springer.com/article/10.1007%2Fs12156-011-0074-3
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Apr 19 2017 at 3:16pm
I did ask the oncologist and she said that while the treatment was given to her earlier in a different setting before she had mets, it's still remains an option to use it in the metastatic setting. Maybe because tumors go thru a genetic transformation sometimes? Not sure, but honestly I'm still not convinced.. 

Edited by rstar - Apr 19 2017 at 3:22pm
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 19 2017 at 6:43pm
rstar,

Sometimes Xeloda is often used in the first line of mets treatment to the lungs as it's easily tolerable and in pill form.

Have you considered getting a second opinion for treatment options?


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Apr 23 2017 at 2:28pm
Thx Donna,

Yea, I'm working on a second opinion.
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