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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jul 16 2018 at 6:43pm

Women with higher vitamin D blood levels have lower risk for breast cancer

Results from a new study published today in PLOS ONE shows women who have higher vitamin D blood levels have a significantly lower risk for breast cancer.

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Aug 05 2018 at 11:28pm

Vitamin D: Recent research uncovers new benefits

Vitamin D and cancer

Breast cancer and bowel cancer have both been linked with cases of vitamin D deficiency in recent studies. One of these analyzed data from two randomized clinical trials and a prospective cohort study.

The researchers found that high levels of vitamin D were inversely associated with risk of breast cancer among women who were cancer-free at baseline.

Studies suggest that vitamin D impacts breast cancer risk.

According to the study results, the higher the levels of vitamin D, the lower the risk of breast cancer.

This relationship remained significant even after the results were adjusted for confounding factors, such as age, body mass index (BMI), intake of calcium supplements, and smoking habits.

Although a link between vitamin D deficiency and colorectal cancer has previously been reported, not all studies have been able to replicate these findings. A new, large-scale study attempted to settle this by drawing on data from three continents, including 5,700 colorectal cancer cases and 7,100 controls.

The researchers alculated that people whose levels of vitamin D fall below those specified in the current guidelines have a 31 percent increased risk of developing bowel cancer. By contrast, those with vitamin D levels above the current recommended levels were 22 percent less likely to develop this cancer.




Edited by 123Donna - Aug 05 2018 at 11:28pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Sep 19 2018 at 7:07pm

'Vitamin D may stop cancer cell growth'

These participants consisted of two groups of women: 209 diagosed with breast cancer, plus 418 cancer-free women who acted as the control group. All the participants had to have stopped menstruating for at least 12 months.

Comparing the medical information collected from the two groups of women, the researchers note that, at the time of diagnosis, the women with breast cancer had higher rates of low or very low serum (blood) vitamin D, compared with their cancer-free counterparts.


"Vitamin D may play a role in controlling breast cancer cells or stopping them from growing. Vitamin D comes from direct sunlight exposure, vitamin D-3 supplements, or foods rich in vitamin D."

To read the entire article:


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Kellyless Quote  Post ReplyReply Direct Link To This Post Posted: Nov 16 2018 at 9:24am
In anticipation of a yearly visit with my GP next week, I had comprehensive blood work done this week. I just got the Vitamin D result - 35 ng/ml. It shows 30-80 as being "normal". Considering my history, is that high enough for me? Donna! Would you take supplements if this was your number? I don't know my GP well at all, I see specialists for the most everything, so I'd like to go in understanding what I can. All my other test results are dandy :) so nice to see strong numbers under WBC, RBC, platelets and liver function since they were all dreadful just 2 years ago when I finished chemo.
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Natalie Quote  Post ReplyReply Direct Link To This Post Posted: Nov 16 2018 at 9:29am
Hi Kelly,
ME personally I like a cushion, I personally like to be at about 50. Since the range is so wide then why not is in my mind.
My doctor was happy at 40, I told him I am pushing for 50 or 60... he smiled.
TNBC stage1 size 1.8, grade3 no nodes 4/11 Lumpectomy 5/11 4cycles DD A/C 4cycles DD Taxol. Double Mastectomy 12/11 BRCA all neg
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Nov 16 2018 at 1:03pm
Hi Kelly,

Personally, I would shoot for something above 50.  My new primary likes the numbers to be at least 70.  I know there is not a general consensus as to what is the ideal number or range and it's so wide.  I take a multivitamin and 5,000 IUs of Vitamin D a day.  This dose helps me get in the upper 50's to mid-60 range.  Hope this information helps. 

Here's a good article to review:

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jan 26 2019 at 11:24am

Does Vitamin D Have a Role in Cancer Prevention?

Cancer Network: What do we know about how much vitamin D we require for optimal health including reducing the risk of cancers?

Dr. Holick: That’s a very good question and obviously, there continues to be a lot of debate about this question. From my perspective, we should really ask the question ‘what were our hunter, gatherer forefathers doing?’ They were always exposed to sunlight. What were their likely levels? How much vitamin D would you require to attain those levels?

One of the insights was done several years ago where a study was performed in Maasai herders that live in Kenya at the equator. Even though they have extremely dark skin, Mother Nature still has the ability to make some vitamin D in their skin.

Their blood levels were measured and it was determined that their 25-hydroxy-vitamin D levels were around 40–50 nanograms per milliliter. To get to that level, adults would need to take 3,000–5,000 units of vitamin D per day.

The recommendation from the Endocrine Society practice guidelines is at least 1,500–2,000 units per day and if you are obese, you need two to three times more. I personally take 5,000 units of vitamin D every day and my blood level is in the range of 60 nanograms per milliliter. All of my patients are on between 3,000–5,000 units of vitamin D per day and they are all doing very well.

Cancer Network: Let’s start with colon cancer. There have been numerous epidemiological studies on the possible benefit of vitamin D in preventing colon cancer. What do individual studies and meta-analyses tell us about vitamin D and colon cancer risk?

Dr. Holick: There continues to be association data saying that the higher your 25-hydroxy-vitamin D levels are, the lower your risk for colorectal cancer.

The earliest study was done by the Garland brothers back in the 1990s when they were relating latitude and colon cancer and then did a prospective study on vitamin D status and the risk of colon cancer.

They concluded two things. The first is that the higher latitude that you live, the higher your risk for colorectal cancer. They also concluded that taking 1,000 units of vitamin D a day could potentially reduce your risk of colon cancer by as much as 50%. Other studies have suggested that improving your vitamin D status would have the benefit of reducing colorectal cancer by about 25%–50%, depending on the study.

Cancer Network: Is there evidence from studies that vitamin D can mitigate the risk of other tumor types?

Dr. Holick: The one that is most significant concerns breast cancer. There was a very nice study was done from the Nurses’ Health Study that showed that nurses that had, on average, blood levels of 48 nanograms per milliliter, so around 50 nanograms per milliliter—that would require you to take about 3,000–5,000 units of vitamin D per day—reduced their risk of developing breast cancer by about 50%.

There was also a very nice study done by Dr. Knight in Canada. She asked a question on the phone to women living in Canada who had breast cancer and asked the same number of women living in the same area who did not have breast cancer and concluded that women who had the most sun exposure as teenagers and young adults reduced the risk of developing breast cancer later in life by almost 70%. So, there is a reasonable amount of evidence to suggest that improvement in vitamin D status can help reduce the risk of breast cancer.

Cancer Network: Have there been randomized trials with vitamin D that focused on cancer prevention or slowing cancer progression?

Dr. Holick: There was a recent study that came out, known as the VITAL study.  The authors concluded that 5 years on 2,000 IU’s of vitamin D per day that did not reduce the risk for developing colon cancer. But, they did find statistically significant 25% reduced risk of dying from colon cancer if patients took vitamin D.

When you look at that study carefully, most of the subjects were not vitamin D deficient.  If they are vitamin D sufficient already, and getting some additional vitamin D, it is not clear that you would be able to see a significant benefit.

The senior author on the publication, Dr. JoAnn Manson, even made the conclusion that it is also true that these types of cancers probably take more than a few years to develop, so introducing vitamin D for 5 years may not be a long enough time to see benefits. That is all the more reason why I encourage my family and my patients that you should always be vigilant about your vitamin D status and take an adequate amount of vitamin D from birth until death.

Cancer Network: Are there currently ongoing human studies to better understand the potential role of vitamin D in cancer prevention?

Dr. Holick: There continue to be small studies that have concluded that there may or may not be any benefit. Again, you have to look at how these trials are designed and what their outcome measures are. I think it is still not clear that maintaining a blood level that we would consider to be in a healthy range for 25-hydroxy-vitamin D of 40–60 nanograms per milliliter as recommended by the Endocrine Society does have that additional health benefit of reducing risk of many deadly cancers. From my perspective, based on all of the information that I have reviewed, I think overall, the data is suggestive that it does help reduce the risk of deadly cancers.

http://www.cancernetwork.com/cancer-management/does-vitamin-d-have-role-cancer-prevention

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Kellyless Quote  Post ReplyReply Direct Link To This Post Posted: Jan 27 2019 at 8:30am
Little follow up: my insurance denied payment for the vitamin D test Angry my doctor dealt with it, probably sent one of these articles Donna has posted. Just infuriating tho!! If my oncologist had ordered it they wouldn't have kicked it back i bet. They said they wouldn't pay for the breast MRI I had that found my tumor last time. When the biopsy came back positive they sent me a letter, "upon further review, we will cover your recent MRI". Health insurance should not be a for profit business! They make money by denying life saving tests and care. I suppose women that haven't had cancer are denied Vitamin tests - where finding deficiencies may prevent diseases like ours in some people? Evil. 

Edited by Kellyless - Jan 27 2019 at 8:31am
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
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