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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Oct 26 2017 at 7:11pm

Researchers discover vitamin D deficiency negatively impacts breast cancer prognosis

The pathology of breast cancer is still unknown, but there are several risk factors that have been associated with this disease. These risk factors include, but are not limited to, age, start of menopause, hormone therapy, family history and oral contraceptive use. Additionally, past research has linked breast cancer risk and survival rates to vitamin D status. However, there has been limited research evaluating the relationship between vitamin D status and prognosis of breast cancer. Therefore, researchers from this study evaluated the effect of vitamin D status on severity of cancer prognosis in a high-risk group of postmenopausal women.

A total of 192 postmenopausal Brazilian women between the ages of 45 and 75 were included in this cross-sectional study. All of the participants attended the Breast Disease Assessment Center of the University Hospital in Southeastern Brazil during 2015-2016. The researchers collected the following data: age, menopausal age, time since menopause, age of first gestation, duration of breastfeeding, current smoking, prior use of hormone therapy, history of chronic diseases, family history of breast cancer and use of medications.

They also measured the patient’s anthropometric data and serum vitamin D levels just following breast cancer diagnosis and prior to medical treatment. Due to the fact that breast cancer prognosis is widely variable, the researchers evaluated several markers that contribute to disease outcome, including:

  • Tumor grade: (1) well differentiated, (2) moderately differentiated, and (3) undifferentiated. While grade 1 tumor cells may look similar to surrounding healthy cells, grade 3 tumors are undifferentiated, or made up of only cancerous cells. This indicates disease progression.
  • Tumor stage: measured by a scale of 1-3; (1) localized invasive breast cancer, (2) inoperable locally advanced invasive breast cancer, and (3) metastatic disease. While localized breast cancer remains within the affected body tissues, metastatic cancer migrates to other parts of the body.
  • Lymph node presence: positive if at least one lymph node were identified as having breast cancer metastasis. This means that the cancer has spread beyond the breast tissue to the rest of the body.
  • Hormone-receptor status: presence or absence of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and cell proliferation index (Ki-67) status. Positive scores for ER and PR receptors mean that the cancer cells will grow in response to estrogen or progesterone, while positive scores for HER2 and Ki-67 indicate increased tumor growth.

This is what the researchers found:

  • Average vitamin D status was 25.8 ng/ml (64.5 nmol/l).
  • Of the total participants, 33.9% were considered to be vitamin D sufficient (>30 ng/ml; >75 nmol/l), 47.9% were considered insufficient (20-30 ng/ml; 50-75 nmol/l) and 18.2% were considered vitamin D deficient (<20 ng/ml; 50 nmol/l).
  • Insufficient and deficient 25(OH)D levels were associated with increased tumor grade, locally advanced and metastatic disease, more positive lymph nodes, a lower proportion of ER, PR-positive tumors and higher Ki-67 indices.
  • Vitamin D status was not significantly associated with tumor size, histology of breast cancer or HER2 status.

The researchers concluded:

“In conclusion, in Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for estrogen receptor-negative tumors, positive axillary lymph node status and a higher rate of cell proliferation.”

https://www.vitamindcouncil.org/researchers-discover-vitamin-d-deficiency-negatively-impacts-breast-cancer-prognosis/




Edited by 123Donna - Oct 26 2017 at 7:15pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 23 2017 at 9:02pm
Vitamin D and Calcium Supplementation Reduces Cancer Risk

Researchers recently presented groundbreaking findings that vitamin D reduces the risk of all cancers at the American Public Health Association’s Annual Meeting. The randomized controlled trial (RCT) was the first to evaluate the effects of vitamin D supplementation on cancer as the primary outcome.

These results have arrived with much anticipation due to the consistent evidence suggesting that higher vitamin D levels and increased sun exposure are linked to lower cancer risk. In fact, over 15 types of cancer have been associated with low sun exposure.

Animal studies have proposed various mechanisms to explain these associations. For instance, vitamin D has been shown to promote cellular differentiation, decrease cancer cell growth, stimulate cell death and decrease tumor blood vessel formation in studies of cancer cell and tumors in mice.

Now, the gold standard of research, a randomized controlled trial, has investigated the direct effects of vitamin D on cancer, and it followed a near flawless study design:

  • Large sample population: The study included 2,302 healthy menopausal women ages 55 and older.
  • Long duration: the experiment lasted four years.
  • Adequate vitamin D3 dose: While the dosage did not quite meet the recommendations of the Vitamin D Council of 5000 IU per day, it provided enough vitamin D to cause a significant increase in vitamin D levels at 2,000 IU per day.
  • Use of a control group: Researchers compared the difference in cancer incidence between the vitamin D group and a control group. The control group received placebo.

After four years of supplementing with 2000 IU of vitamin D3 daily, the average vitamin D levels of the vitamin D group increased from 32.8 ng/ml to 43.9 ng/ml. The control group’s average levels decreased slightly from an average of 32.8 ng/ml to 31.6 ng/ml.

Throughout the four years, 106 of the 2,300 women developed at least one type of non-skin cancer. The researchers discovered that cancer incidence (43 treatment and 63 controls) was significantly lower in the treatment group (p < 0.05). Furthermore, the analyses revealed that both vitamin D supplementation and vitamin D status were significant predictors of cancer risk after one year of intervention.

The researchers stated,

“Supplementing with 2000 IU/day of vitamin D3 and 1500 mg/day of calcium substantially reduced risk of all cancers combined. This finding provides great impetus for improving vitamin D status through advances in vitamin D nutritional policy.”

This study presented a groundbreaking discovery for public health. Cancer is the number two cause of death in the United States with approximately 40% of men and women developing cancer in their lifetime. This upsetting percentage could decrease through the identification of modifiable risk factors, such as vitamin D and calcium supplementation.

http://www.vitamindcouncil.org/vitamin-d-and-calcium-supplementation-reduces-cancer-risk-according-to-rct/

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 07 2017 at 10:53pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote *Nancy Quote  Post ReplyReply Direct Link To This Post Posted: Feb 07 2017 at 9:11pm
In lieu of taking oral Vitamin D-3, I know they recommend going outside for daily sun exposure so that your body can produce its own natural Vitamin D.
Does anyone know the answer to this?
1. How long are you supposed to be in the sun? Is it daily or is once a week sufficient?
2. What amount of skin surface area should be exposed in order to reap the benefit?
3. Does it work if you apply sunscreen or is it supposed to be on exposed, unprotected skin?
Dx March 2010, age 54, 5 mm tumor, Stage Ia, Grade 3, 0/3 Nodes, Ki-67 70%,

Lumpectomy April 2010, TC x 4, Rads x 33, Treatment completed Sept 2010, NED 06/17
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Post Options Post Options   Thanks (1) Thanks(1)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jan 06 2017 at 11:53am
Vitamin D and Colorectal Cancer Risk

A new meta-analysis of 15 studies found that healthy vitamin D status was associated with lower risk of colorectal cancer.

Colorectal cancer is the third most common cancer among men and women in the United States. When detected early, colorectal cancer is highly treatable. However, the most difficult cases occur when the cancer has spread throughout the body to the liver or lungs. In these cases, chemotherapy, radiotherapy or surgery may help. Research has focused on developing more treatments for later stages of colorectal cancer to provide a greater likelihood of a successful recovery.

Studies have shown a relationship between healthy vitamin D status and a longer survival among colorectal patients, suggesting vitamin D may play an important in colorectal cancer outcome.

Researchers recently conducted a meta-analysis of 15 case-control studies to examine the relationship between vitamin D levels and risk of colorectal cancer. All but two of the 15 studies found that higher vitamin D levels were associated with a lower risk of colorectal cancer.

According to their analysis, individuals with a vitamin D status of 50 ng/ml had a 60% reduced risk of colorectal cancer compared to those with levels of 5 ng/ml. In addition, those with vitamin D levels of 30 ng/ml had a 33% reduced risk of colorectal cancer compared to individuals with levels of 5 ng/ml.

The researchers concluded,

“The inverse association between serum 25(OH)D and risk of colorectal cancer overall was strong and statistically significant.”

Clinical trials are needed to determine whether vitamin D supplementation may help prevent or improve outcomes for colorectal cancer patients.

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 20 2016 at 8:10pm
thank you! that's a good price on Carlson Vid D


Edited by gordon15 - Dec 20 2016 at 8:11pm
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 20 2016 at 8:08pm
Thanks you Main & Donna, for the info. I bought enough Vit D for a year, but I wanted to pass along that my wife figured-out her IBS problem by herself, before going to a gastro-e. She did not have ENOUGH stomach acid.
 She had (sorry for the image) un-digested food, she's been taking Hydrochloric acids pills, she takes (2) if eating meat, the supplement has a digestive enzyme included also.

I don't know if this is result of chemo,(we suspect) but she eliminated foods, one by one, and then she found 'gluten' was not being tolerated, in her system.

Hope this helps someone... G

wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 20 2016 at 7:47am
From Dr. Weil:

Vitamin D is an essential micronutrient with a central role in maintaining health. I recommend prudent daily sun exposure to support the natural production of vitamin D in our skin as one of the best ways to get enough of this vitamin. But if, like many these days, you have few opportunities to go outside due to work, school, or weather, you may be at risk for vitamin D deficiency. Decreased or insufficient levels of vitamin D have been linked to:

  1. Suppressed immunity: Our innate systems of defense may not function efficiently without adequate vitamin D, allowing increased susceptibility to infectious agents.
  2. Increased risk of chronic disease: Low levels of vitamin D have been associated with a higher-than-normal risk of heart disease and several kinds of cancer.
  3. Heightened inflammation: Vitamin D is a key cofactor in regulating inflammation throughout the body.
  4. Falls: Older persons with low vitamin D are at a greater risk of falls, which are a major cause of hip fracture and chronic pain.

Speak with your doctor about checking your 25-hydroxy (25-OH) vitamin D level, and ask if supplementation may be needed. 

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Dec 16 2016 at 10:06pm
Oh dear, Gordon I didn't mean to lead you astray, the Carson are great and the New Zealand origin is fine. Like you said, supplements from China...mmm...not so much. I'm now on day 2 of the liquid and I'm muttering to myself that I don't like trying to figure out doseage. The Carlson single pill is so much easier to take.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 16 2016 at 8:16pm
thank you, I will show it to my wife...very much appreciate .
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 16 2016 at 7:16pm
Gordon,

Here's a link to Carlson:



DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 16 2016 at 6:49pm
Thank you for your imput, I have not heard of Carlson (Vitamins, I assume) I will research.
I didn't know vitamin supplements from New Zealand are a problem. China, for sure, we want to know, because we don't want to buy anything consumable from China. If you don't believe me, try googling "farm -raised tilapia in China" and notice the chicken cages sit on top of the fish ponds.
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Dec 14 2016 at 1:18pm
Gordon, the research is really important, glad you have found a couple you like. I called Carlson and asked them where they sourced their D from and they said not from China but from New Zealand...I have used the 4,000 IU Carlson for about 6 years now. Yesterday I broke my habit and bought a bottle of the liquid D so we'll see how that works !
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 13 2016 at 9:36pm
Gordon,

I take 5,000 ius of D3 a day, along with magnesium plus a multivitamin.   I went from being deficient to very good levels - in the 60's.  
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 13 2016 at 5:38pm
Thank you all for your replies. my wife is taking 1000mg/ per day of Vitamin D, I will talk to her and see if she needs to be taking more.

I checked prices on Amazon for vitamin suppliers we trust ...and have researched their additives, and etc...the Riteaid 2-for-1 is good value only with that promotion...but Amazon has a good price  that should be compared:
'Source Naturals' and '21st Century' both have a competitive price. I have researched both companies, and they have good reviews, as far as not sourcing ingredients from China.

Thank you for reminding us to take CalMagZinc. That is very much appreciated.
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Dec 10 2016 at 6:52pm
Gordon, the RDA is 1,000 a day however I found early on that for Tneg patients that's not enough. I've been taking 4,000 IU a day for 6 years now and that maintains the level I need to have (I aim for low 60's). Also, the D should be taken with a CalMag supplement for absorption. Best of luck to you both.
Mainy
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Tulips Quote  Post ReplyReply Direct Link To This Post Posted: Dec 10 2016 at 10:23am
Sounds like perfect advice, Donna & Gordon.  It can only help us to get those levels up!

Edited by Tulips - Dec 10 2016 at 10:26am
Dx April 2015 IDC TN 2.2 cm, Grade 3, Chemo started May 2015: Taxol/Carbo then AC, Lx with SNB Nov 2015, 33 Rad Dec 2015-Feb 2016. 6 months Capecitabine starting March 2016
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 09 2016 at 7:39pm
Tulips,

I read somewhere that almost all TNBC are deficient at diagnosis for Vitamin D.  Maybe this contributes to TNBC's poor prognosis?  I don't know if it's the chicken or egg scenario, but there seems to be a connection.  I think it's important for everyone to know their Vit D level, just like cholesterol and blood pressure.  Vit D is more than a vitamin, it's a hormone that helps regulate the body.  As one of my oncs told me, being deficient is never a good thing.  After treatment the first time I found out I was deficient and got my levels up - it took several months.  I still had a recurrence but maybe having normal levels for the 2nd diagnosis helped treatment be more effective?  It's a simple blood test that everyone should get so they know their Vit D levels.  I'm so glad my primary doctor includes it in my annual lab work so that I can monitor my level and make sure it's where I want it to be.

Donna 
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 09 2016 at 6:00pm
My wife takes the Vit D, I bought (2) bottles yesterday at RiteAid, 1000mg, buy one get one free, that's still $8.50 /bottle, but I am sure it helps.
I want everyone to know, in 2008, my wife had chemo and it took her 12-16 months to get red blood cell counts back...

This year, she took Vit B-12 and Folic Acid pills, and I am sure it was instrumental in her red-blood-cell-count coming back much sooner... fyi
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Tulips Quote  Post ReplyReply Direct Link To This Post Posted: Dec 09 2016 at 5:24pm
Thanks, Donna!  It's so useful to see this, because we can pass this info on to everyone we love.  

I admit, I personally find these results a bit discouraging regarding my own case, because all of these studies seem to indicate that low levels of vitamin D AT DIAGNOSIS results in a poor prognosis.  I was tested soon after diagnosis, and my levels were low.  Since then, I've been supplementing and getting more direct sun without sunblock, and my levels are on the rise.   However, these studies don't really indicate that getting your levels up AFTER diagnosis affects your prognosis, do they?  I'm not saying that I'll stop trying--it seems logical to me that getting/keeping my levels up can only be a good thing.  But it mostly seems important that healthy people make sure their levels are up, in advance of a diagnosis.  Fingers crossed  it helps!

Tulips
Dx April 2015 IDC TN 2.2 cm, Grade 3, Chemo started May 2015: Taxol/Carbo then AC, Lx with SNB Nov 2015, 33 Rad Dec 2015-Feb 2016. 6 months Capecitabine starting March 2016
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